undamentalytics Newsletter

Orbimed Capital Gp VI LLC: insider trades

Director, 10% owner at 7 companies we cover. 6 open-market purchases and 6 sales not made under a pre-set plan, reported from January 24, 2018 to April 11, 2025.

Would copying Orbimed Capital Gp VI LLC’s purchases have beaten the S&P 500?

Too few purchases to judge. Only 5 purchases have 12 months of prices after the report; we judge insiders once they have 20. The figures below can swing a long way on a handful of trades. Buying each purchase the day after it was reported, an equal amount each, and holding it 12 months or until they reported a sale would have turned $10,000 on January 25, 2018 into $13,670 by November 2, 2026, +3.6% a year. The copy held shares only 39% of the time, so the fair comparison is the S&P 500 on those same days with Treasury bills otherwise: $15,786, +5.4% a year (the S&P 500 held throughout made $30,492, +13.6% a year). Beta against the index was 0.42. Twelve months after each report, the average purchase was +1.6% against the S&P 500 (median +33.3%), and 60% beat it. Measured from the trade date, the insider’s own timing, the average was +3.2%. After their sales, the shares moved −23.4% against the index over 12 months on average (a negative figure means selling was the right call); 80% trailed it.

With 296 insiders tested, some will look skilled or unskilled by chance alone: when we replaced each insider’s stocks with random companies bought on the same days, about 5.7 cleared the bar ahead and 23.3 behind. One record on its own proves little.

$0$10.0k$20.0k$30.0k 201820192020202120222023202420252026 $30.5k$15.8k$13.7k
Copying Orbimed Capital Gp VI LLCS&P 500, same days investedS&P 500, held throughout $10,000 copying Orbimed Capital Gp VI LLC’s open-market purchases from January 25, 2018, before costs and taxes, marked weekly. Each purchase gets the same starting stake, bought at the close of the first trading day after the report and sold 12 months later or the day after a reported sale of that stock; uninvested money earns the Treasury bill rate. “Same days invested” holds the S&P 500 only on the days the copy held shares, Treasury bills otherwise.
Return a year, copying
+3.6%
S&P 500, same days invested
+5.4% (held throughout +13.6%)
Time in shares
39%
Sharpe ratio (S&P 500)
0.28 (0.62)
Biggest drop (S&P 500)
−79% (−34%)
Market sensitivity (beta)
0.42
Purchases copied
5

Trade by trade

Orbimed Capital Gp VI LLC: trades against the S&P 500 afterwards
MeasuredTrades countedAverage vs S&P 500MedianWent the right wayYearst-statisticp-valueEvidence
Purchases, 3 months after the report 5 +6.4% +12.2% 60% 4 0.29 0.79 No reliable evidence
Purchases, 6 months after the report 5 +2.2% −3.3% 40% 4 0.60 0.59 No reliable evidence
Purchases, 12 months after the report 5 +1.6% +33.3% 60% 4 0.66 0.56 No reliable evidence
Purchases, 12 months after the trade 5 +3.2% +17.7% 60% 4 0.68 0.54 No reliable evidence
Sales, 3 months after the report 5 −19.9% −9.3% 80% 3 — — Not enough years
Sales, 12 months after the report 5 −23.4% −29.0% 80% 3 — — Not enough years
Sales, 12 months after the trade 5 −25.9% −29.0% 100% 3 — — Not enough years

“Average vs S&P 500” is the stock’s return including dividends minus the index’s over the same dates, from the close on the first trading day after the report, or from the close on the trade date. Only windows that have finished are counted. For sales, a negative figure means the stock lagged after it was sold, so selling was the right call (green). “Went the right way” is the share of purchases that beat the index, or of sales that trailed it. The t-statistic uses one average per year of reports, because one person’s trades bunch into the same stock and weeks, and needs trades in at least four different years; the p-value comes from the t distribution with that number of years (with four years, a t of 2 has p = 0.14). “Some evidence” means p under 5%, “strong evidence” p under 1% over at least six years.

Companies traded

CompanyTitle on the latest filingPurchasesSalesFirst reportLatest report
Neuropace Inc NPCE —03October 4, 2023April 18, 2024
Kala BIO, Inc. KALA —20January 24, 2018February 2, 2018
Edgewise Therapeutics, Inc. EWTX —20May 20, 2022January 25, 2024
Disc Medicine, Inc. IRON —02March 12, 2025March 21, 2025
Imagenebio, Inc. IMA —10June 24, 2022June 24, 2022
ARS Pharmaceuticals, Inc. SPRY —10August 31, 2023August 31, 2023
Compass Therapeutics, Inc. CMPX —01April 11, 2025April 11, 2025

Trades and what followed

Moves are against the S&P 500; green means the trade went the insider’s way.

ReportedTradedCompanyTradeValue3 months after report12 months after report12 months after trade
April 11, 2025April 9, 2025 CMPX Sale $5,678,571 not yetnot yetnot yet
March 21, 2025March 19, 2025 IRON Sale $2,831,987 −3.6%+0.8%−7.8%
March 12, 2025March 10, 2025 IRON Sale $16,965,596 −9.2%−6.6%−2.4%
April 18, 2024April 16, 2024 NPCE Sale $238,231 −57.7%−31.5%−29.0%
April 15, 2024April 11, 2024 NPCE Sale $7,026,033 −57.5%−29.0%−31.8%
January 25, 2024January 23, 2024 EWTX Purchase $4,999,995 −6.7%+47.0%+56.1%
October 4, 2023October 2, 2023 NPCE Sale $75,449 +28.5%−50.6%−58.4%
August 31, 2023August 29, 2023 SPRY Purchase $3,100,000 −32.5%+44.0%+57.0%
June 24, 2022June 22, 2022 IMA Purchase $1,128,021 not yetnot yetnot yet
May 20, 2022May 18, 2022 EWTX Purchase $994,980 +44.2%+33.3%+17.7%
February 2, 2018January 31, 2018 KALA Purchase $5,433,372 +14.8%−56.7%−59.3%
January 24, 2018January 12, 2018 KALA Purchase $3,828,990 +12.2%−59.8%−55.5%

Open-market purchases and sales of at least $10,000 in companies we cover, from SEC Form 4 filings; sales made under a pre-set Rule 10b5-1 plan are not shown. “Not yet” means the window has not finished or the share price was under $5 at entry. These are the shares’ moves after each trade: they say nothing about why Orbimed Capital Gp VI LLC traded and do not suggest the use of non-public information. How every insider compares · the insider trading backtest.