Amylyx Pharmaceuticals, Inc.: which funds bought and sold

Institutions that bought and sold Amylyx Pharmaceuticals shares in Q2 2026, from the holdings they reported to the SEC on Form 13F for March 31, 2026 and June 30, 2026.

Between March 31, 2026 and June 30, 2026, 118 institutions that filed 13F reports for both quarters added to or opened positions in Amylyx Pharmaceuticals, and 72 cut or closed them. Together they added a net 213K shares, +0.2% on what they held at the start of the quarter. Active managers and hedge funds on our list were net sellers of 323K shares (−0.6%); index fund managers were net buyers of 672K shares (+3.2%). 47 opened a new position and 13 sold out entirely.

Bought, Q2 2026 118 institutions, 47 of them new holders Sold, Q2 2026 72 institutions, 13 of them sold out

Net change, all compared +213K shares (+0.2%)

Net change, active managers −323K shares (−0.6%), 26 bought, 17 sold

Buyers versus sellers

institutions compared, 215

118 bought 25 72 sold

Active managers and hedge funds 26 bought · 17 sold · −323K

Index fund managers 9 bought · 3 sold · +672K

Other institutions 83 bought · 52 sold · −136K

Biggest buyers

by change in shares held

Biggest buyers
Institution	Change in shares	Shares June 30, 2026	Value
Jpmorgan Chase & Co	+1.7M +1067.2%	1.9M	$34.9M
Alyeska Investment Group, L.P. Hedge fund	+1.1M New position	1.1M	$18.9M
Morgan Stanley	+955K +43.9%	3.1M	$56.2M
Aberdeen Group PLC	+738K New position	738K	$13.2M
Franklin Resources Inc Active manager	+689K +30.5%	3.0M	$53M
Nantahala Capital Management, LLC Hedge fund	+438K +81.7%	973K	$17.5M
Two Sigma Investments, LP Hedge fund	+431K +266.4%	593K	$10.7M
Nearwater Capital Markets, Ltd	+425K New position	425K	$7.6M
Trexquant Investment LP Hedge fund	+349K New position	349K	$6.3M
Ensign Peak Advisors, Inc	+305K New position	305K	$5.5M
Jane Street Group, LLC	+300K New position	300K	$5.4M
Saturn V Capital Management LP	+274K +6.3%	4.6M	$83M
First Trust Advisors LP	+255K New position	255K	$4.6M
Siren, L.L.C.	+251K +20.4%	1.5M	$26.6M
State Street Corp Index funds	+240K +10.2%	2.6M	$46.8M
Goldman Sachs Group Inc	+232K +8.8%	2.9M	$51.3M
Orbimed Advisors LLC	+183K New position	183K	$3.3M
Ameriprise Financial Inc	+125K New position	125K	$2.3M
Walleye Capital LLC Hedge fund	+125K +202.4%	187K	$3.4M
Geode Capital Management, LLC Index funds	+124K +5.6%	2.3M	$41.9M

Biggest buyers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
Alyeska Investment Group, L.P. Hedge fund	+1.1M New position	1.1M	$18.9M
Franklin Resources Inc Active manager	+689K +30.5%	3.0M	$53M
Nantahala Capital Management, LLC Hedge fund	+438K +81.7%	973K	$17.5M
Two Sigma Investments, LP Hedge fund	+431K +266.4%	593K	$10.7M
Trexquant Investment LP Hedge fund	+349K New position	349K	$6.3M
Walleye Capital LLC Hedge fund	+125K +202.4%	187K	$3.4M
Lighthouse Investment Partners, LLC Hedge fund	+123K New position	123K	$2.2M
D. E. Shaw & Co., Inc. Hedge fund	+100K +134.8%	174K	$3.1M
Federated Hermes, Inc. Active manager	+99K +27.1%	462K	$8.3M
FMR LLC Active manager	+97K +0.6%	16.7M	$300M

Biggest sellers

by change in shares held

Biggest sellers
Institution	Change in shares	Shares June 30, 2026	Value
Adage Capital Partners Gp, L.L.C. Hedge fund	−1.7M −46.6%	1.9M	$34.1M
Almitas Capital LLC	−1.1M −54.1%	975K	$17.5M
Great Point Partners LLC	−1.1M −60.0%	700K	$12.6M
Stempoint Capital LP	−955K −71.3%	384K	$6.9M
Barclays PLC	−916K −94.2%	56K	$1M
Deutsche Bank Ag\	−710K −56.0%	558K	$10M
Jones Hill Capital LP	−705K −44.1%	894K	$16.1M
Bank Of America Corp	−509K −38.2%	822K	$14.8M
ADAR1 Capital Management, LLC Hedge fund	−506K −50.6%	494K	$8.9M
Balyasny Asset Management L.P. Hedge fund	−422K −38.1%	685K	$12.3M
Logos Global Management LP Hedge fund	−350K −50.0%	350K	$6.3M
Jupiter Asset Management Ltd Active manager	−318K −53.6%	275K	$4.9M
683 Capital Management, LLC Hedge fund	−250K −16.4%	1.3M	$23M
Citadel Advisors LLC Hedge fund	−233K −56.6%	179K	$3.2M
Parkman Healthcare Partners LLC	−223K −35.8%	399K	$7.2M
Eventide Asset Management, LLC	−186K −12.3%	1.3M	$23.8M
First Light Asset Management, LLC	−167K −5.2%	3.0M	$54.3M
Cormorant Asset Management, LP Hedge fund	−150K −42.9%	200K	$3.6M
Connor, Clark & Lunn Investment Management Ltd.	−147K −17.0%	721K	$12.9M
Squarepoint Ops LLC Hedge fund	−115K Sold out	0	—

Biggest sellers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
Adage Capital Partners Gp, L.L.C. Hedge fund	−1.7M −46.6%	1.9M	$34.1M
ADAR1 Capital Management, LLC Hedge fund	−506K −50.6%	494K	$8.9M
Balyasny Asset Management L.P. Hedge fund	−422K −38.1%	685K	$12.3M
Logos Global Management LP Hedge fund	−350K −50.0%	350K	$6.3M
Jupiter Asset Management Ltd Active manager	−318K −53.6%	275K	$4.9M
683 Capital Management, LLC Hedge fund	−250K −16.4%	1.3M	$23M
Citadel Advisors LLC Hedge fund	−233K −56.6%	179K	$3.2M
Cormorant Asset Management, LP Hedge fund	−150K −42.9%	200K	$3.6M
Squarepoint Ops LLC Hedge fund	−115K Sold out	0	—
Point72 Asset Management, L.P. Hedge fund	−107K Sold out	0	—

New positions

largest by value

Institution	Shares	Value June 30, 2026
Alyeska Investment Group, L.P.Hedge fund	1.1M	$18.9M
Aberdeen Group PLC	738K	$13.2M
Nearwater Capital Markets, Ltd	425K	$7.6M
Trexquant Investment LPHedge fund	349K	$6.3M
Ensign Peak Advisors, Inc	305K	$5.5M
Jane Street Group, LLC	300K	$5.4M
First Trust Advisors LP	255K	$4.6M
Orbimed Advisors LLC	183K	$3.3M
Ameriprise Financial Inc	125K	$2.3M
Lighthouse Investment Partners, LLCHedge fund	123K	$2.2M

Sold out

largest by value

Institution	Shares	Value March 31, 2026
Squarepoint Ops LLCHedge fund	115K	$1.6M
Point72 Asset Management, L.P.Hedge fund	107K	$1.5M
Informed Momentum Co LLC	53K	$740,258
Integrated Quantitative Investments LLC	27K	$378,553
Headlands Technologies LLC	20K	$275,415
Verition Fund Management LLCHedge fund	13K	$184,370
Landscape Capital Management, L.L.C.	12K	$169,941
Mai Capital Management	9,014	$125,295
Act Capital Management, LLC	9,000	$125,100
Meeder Asset Management Inc	661	$9,188

Who holds the shares

13F holdings at June 30, 2026

Institutions reporting: 206
Ten largest holders: 57.2%
Index fund managers: 18.5%
Active managers and hedge funds: 43.3%

Buying and selling by type of institution, March 31, 2026 to June 30, 2026
Type	Bought	Sold	New	Sold out	Net change in shares	Net %
Active managers and hedge funds	26	17	11	3	−323K	−0.6%
Index fund managers	9	3	1	0	+672K	+3.2%
Other institutions	83	52	35	10	−136K	−0.3%

Active managers and hedge funds: a list we maintain of about 400 well-known stock-picking firms and hedge funds, matched by SEC registration number (CIK) and checked against the filer names each quarter. Index fund managers: the large index houses, such as BlackRock, Vanguard, State Street, Geode and Northern Trust. Every other filer (banks, brokers, wealth managers, pension funds, insurers and firms not on the list) counts as another institution. A firm that files under several SEC registrations appears once for each.

What these filings can and cannot tell you

Form 13F lists the long positions in US-listed shares held by investment managers with more than $100 million in such holdings. Managers file it up to 45 days after each quarter ends, so this page shows what funds held at the end of each quarter, not what they are doing now: a position may have changed since. Short positions, most derivatives and smaller managers are not included, and a cut can mean a fund lost clients or rebalanced rather than a view on Amylyx Pharmaceuticals.

Only managers that filed a holdings report for both quarters are compared (215 here). 6 other holders are left out: first-time or late filers, firms that changed their SEC registration, and filings that withheld positions under confidential treatment, any of which would otherwise look like a new position or a sale. Figures are as reported by each manager in the SEC's quarterly 13F data sets; option positions are excluded.

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