C4 Therapeutics, Inc.: which funds bought and sold

Institutions that bought and sold C4 Therapeutics shares in Q2 2026, from the holdings they reported to the SEC on Form 13F for March 31, 2026 and June 30, 2026.

Between March 31, 2026 and June 30, 2026, 104 institutions that filed 13F reports for both quarters added to or opened positions in C4 Therapeutics, and 53 cut or closed them. Together they added a net 32.7M shares, +38.5% on what they held at the start of the quarter. Active managers and hedge funds on our list were net buyers of 2.8M shares (+8.9%); index fund managers were net buyers of 12.0M shares (+142.6%). 51 opened a new position and 25 sold out entirely.

Bought, Q2 2026 104 institutions, 51 of them new holders Sold, Q2 2026 53 institutions, 25 of them sold out

Net change, all compared +32.7M shares (+38.5%)

Net change, active managers +2.8M shares (+8.9%), 24 bought, 16 sold

Buyers versus sellers

institutions compared, 172

104 bought 15 53 sold

Active managers and hedge funds 24 bought · 16 sold · +2.8M

Index fund managers 10 bought · 1 sold · +12.0M

Other institutions 70 bought · 36 sold · +18.0M

Biggest buyers

by change in shares held

Biggest buyers
Institution	Change in shares	Shares June 30, 2026	Value
Blackrock, Inc. Index funds	+5.8M +285.5%	7.9M	$36.9M
Squadron Capital Management LLC	+5.0M +220.0%	7.2M	$33.6M
Ikarian Capital, LLC	+2.4M New position	2.4M	$11.4M
Candriam S.C.A.	+1.8M New position	1.8M	$8.4M
State Street Corp Index funds	+1.7M +452.4%	2.1M	$9.9M
Citadel Advisors LLC Hedge fund	+1.7M +66.8%	4.2M	$19.6M
Patient Square Capital LP	+1.6M New position	1.6M	$7.5M
Geode Capital Management, LLC Index funds	+1.6M +165.2%	2.5M	$11.8M
Jpmorgan Chase & Co	+1.5M +47.3%	4.7M	$20.7M
Highvista Strategies LLC	+1.3M New position	1.3M	$6.3M
Goldman Sachs Group Inc	+1.1M +47.9%	3.5M	$16.5M
Silverarc Capital Management, LLC	+1.1M +58.6%	3.0M	$14.2M
Northern Trust Corp Index funds	+971K +512.5%	1.2M	$5.4M
Dimensional Fund Advisors LP	+746K +168.6%	1.2M	$5.5M
Boothbay Fund Management, LLC Hedge fund	+736K New position	736K	$3.4M
D. E. Shaw & Co., Inc. Hedge fund	+681K +64.2%	1.7M	$8.1M
Vanguard Portfolio Management LLC Index funds	+680K New position	680K	$3.2M
FMR LLC Active manager	+622K +228.3%	894K	$4.2M
UBS Group AG	+613K +284.0%	829K	$3.9M
Velan Capital Investment Management LP	+570K New position	570K	$2.7M

Biggest buyers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
Citadel Advisors LLC Hedge fund	+1.7M +66.8%	4.2M	$19.6M
Boothbay Fund Management, LLC Hedge fund	+736K New position	736K	$3.4M
D. E. Shaw & Co., Inc. Hedge fund	+681K +64.2%	1.7M	$8.1M
FMR LLC Active manager	+622K +228.3%	894K	$4.2M
Wasatch Advisors LP Active manager	+561K +18.9%	3.5M	$16.5M
Exoduspoint Capital Management, LP Hedge fund	+533K +1121.3%	580K	$2.7M
Two Sigma Investments, LP Hedge fund	+434K +14.3%	3.5M	$16.2M
Adage Capital Partners Gp, L.L.C. Hedge fund	+325K New position	325K	$1.5M
ADAR1 Capital Management, LLC Hedge fund	+249K +579.0%	292K	$1.4M
Wellington Management Group LLP Active manager	+228K New position	228K	$1.1M

Biggest sellers

by change in shares held

Biggest sellers
Institution	Change in shares	Shares June 30, 2026	Value
Renaissance Technologies LLC Hedge fund	−1.3M −51.7%	1.2M	$5.6M
Millennium Management LLC Hedge fund	−1.2M −84.5%	215K	$1M
Jane Street Group, LLC	−944K −75.7%	303K	$1.4M
Orbimed Advisors LLC	−856K Sold out	0	—
Soleus Capital Management, L.P. Hedge fund	−426K −11.2%	3.4M	$15.8M
Wells Fargo & Company	−415K −47.8%	453K	$2.1M
Stempoint Capital LP	−383K −42.2%	524K	$2.4M
Qube Research & Technologies Ltd Hedge fund	−382K −50.7%	371K	$1.7M
683 Capital Management, LLC Hedge fund	−300K Sold out	0	—
Barclays PLC	−243K −76.6%	75K	$347,989
Jacobs Levy Equity Management, Inc Active manager	−240K −90.5%	25K	$117,268
Hennion & Walsh Asset Management, Inc.	−223K Sold out	0	—
Morgan Stanley	−205K −2.3%	8.9M	$41.4M
Toronto Dominion Bank	−174K −99.6%	640	$2,989
HRT Financial LP	−163K Sold out	0	—
Hudson Bay Capital Management LP Hedge fund	−130K Sold out	0	—
Mariner, LLC	−128K Sold out	0	—
Walleye Capital LLC Hedge fund	−124K −51.9%	115K	$537,634
BNP Paribas Financial Markets	−116K −60.9%	74K	$347,322
Verdad Advisers, LP	−109K Sold out	0	—

Biggest sellers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
Renaissance Technologies LLC Hedge fund	−1.3M −51.7%	1.2M	$5.6M
Millennium Management LLC Hedge fund	−1.2M −84.5%	215K	$1M
Soleus Capital Management, L.P. Hedge fund	−426K −11.2%	3.4M	$15.8M
Qube Research & Technologies Ltd Hedge fund	−382K −50.7%	371K	$1.7M
683 Capital Management, LLC Hedge fund	−300K Sold out	0	—
Jacobs Levy Equity Management, Inc Active manager	−240K −90.5%	25K	$117,268
Hudson Bay Capital Management LP Hedge fund	−130K Sold out	0	—
Walleye Capital LLC Hedge fund	−124K −51.9%	115K	$537,634
Brevan Howard Capital Management LP Hedge fund	−93K Sold out	0	—
Acadian Asset Management LLC Active manager	−85K −4.5%	1.8M	$8.4M

New positions

largest by value

Institution	Shares	Value June 30, 2026
Ikarian Capital, LLC	2.4M	$11.4M
Candriam S.C.A.	1.8M	$8.4M
Patient Square Capital LP	1.6M	$7.5M
Highvista Strategies LLC	1.3M	$6.3M
Boothbay Fund Management, LLCHedge fund	736K	$3.4M
Vanguard Portfolio Management LLCIndex funds	680K	$3.2M
Velan Capital Investment Management LP	570K	$2.7M
Rockefeller Capital Management L.P.	496K	$2.3M
Nuveen, LLC	484K	$2.3M
Adage Capital Partners Gp, L.L.C.Hedge fund	325K	$1.5M

Sold out

largest by value

Institution	Shares	Value March 31, 2026
Orbimed Advisors LLC	856K	$2.3M
683 Capital Management, LLCHedge fund	300K	$789,000
Hennion & Walsh Asset Management, Inc.	223K	$586,932
HRT Financial LP	163K	$428,000
Hudson Bay Capital Management LPHedge fund	130K	$342,113
Mariner, LLC	128K	$334,171
Verdad Advisers, LP	109K	$287,740
Brevan Howard Capital Management LPHedge fund	93K	$243,662
Omers Administration Corp	60K	$157,011
Readystate Asset Management LP	50K	$130,411

Who holds the shares

13F holdings at June 30, 2026

Institutions reporting: 147
Ten largest holders: 53.9%
Index fund managers: 17.3%
Active managers and hedge funds: 29.0%

Buying and selling by type of institution, March 31, 2026 to June 30, 2026
Type	Bought	Sold	New	Sold out	Net change in shares	Net %
Active managers and hedge funds	24	16	9	6	+2.8M	+8.9%
Index fund managers	10	1	2	0	+12.0M	+142.6%
Other institutions	70	36	40	19	+18.0M	+39.7%

Active managers and hedge funds: a list we maintain of about 400 well-known stock-picking firms and hedge funds, matched by SEC registration number (CIK) and checked against the filer names each quarter. Index fund managers: the large index houses, such as BlackRock, Vanguard, State Street, Geode and Northern Trust. Every other filer (banks, brokers, wealth managers, pension funds, insurers and firms not on the list) counts as another institution. A firm that files under several SEC registrations appears once for each.

What these filings can and cannot tell you

Form 13F lists the long positions in US-listed shares held by investment managers with more than $100 million in such holdings. Managers file it up to 45 days after each quarter ends, so this page shows what funds held at the end of each quarter, not what they are doing now: a position may have changed since. Short positions, most derivatives and smaller managers are not included, and a cut can mean a fund lost clients or rebalanced rather than a view on C4 Therapeutics.

Only managers that filed a holdings report for both quarters are compared (172 here). 1 other holder is left out: first-time or late filers, firms that changed their SEC registration, and filings that withheld positions under confidential treatment, any of which would otherwise look like a new position or a sale. Figures are as reported by each manager in the SEC's quarterly 13F data sets; option positions are excluded.

← Back to C4 Therapeutics, Inc. · Insiders · Politicians