Design Therapeutics, Inc.: which funds bought and sold

Institutions that bought and sold Design Therapeutics shares in Q2 2026, from the holdings they reported to the SEC on Form 13F for March 31, 2026 and June 30, 2026.

Between March 31, 2026 and June 30, 2026, 90 institutions that filed 13F reports for both quarters added to or opened positions in Design Therapeutics, and 48 cut or closed them. Together they added a net 5.3M shares, +14.0% on what they held at the start of the quarter. Active managers and hedge funds on our list were net sellers of 1.7M shares (−9.5%); index fund managers were net buyers of 1.3M shares (+23.0%). 28 opened a new position and 16 sold out entirely.

Bought, Q2 2026 90 institutions, 28 of them new holders Sold, Q2 2026 48 institutions, 16 of them sold out

Net change, all compared +5.3M shares (+14.0%)

Net change, active managers −1.7M shares (−9.5%), 17 bought, 17 sold

Buyers versus sellers

institutions compared, 151

90 bought 13 48 sold

Active managers and hedge funds 17 bought · 17 sold · −1.7M

Index fund managers 9 bought · 0 sold · +1.3M

Other institutions 64 bought · 31 sold · +5.7M

Biggest buyers

by change in shares held

Biggest buyers
Institution	Change in shares	Shares June 30, 2026	Value
Frazier Life Sciences Management, L.P.	+1.8M New position	1.8M	$26.2M
Trails Edge Capital Partners, LP	+1.1M +134.9%	2.0M	$29M
Logos Global Management LP Hedge fund	+1.1M +53.8%	3.0M	$43.4M
Caption Management, LLC	+1.0M +1189.5%	1.1M	$16.2M
Driehaus Capital Management LLC Active manager	+916K +52.5%	2.7M	$38.5M
Sofinnova Investments, Inc.	+865K New position	865K	$12.5M
Blackrock, Inc. Index funds	+526K +24.7%	2.7M	$38.5M
Siren, L.L.C.	+523K New position	523K	$7.6M
Qube Research & Technologies Ltd Hedge fund	+403K +1178.6%	437K	$6.3M
Jacobs Levy Equity Management, Inc Active manager	+276K +95.4%	566K	$8.2M
Geode Capital Management, LLC Index funds	+266K +38.4%	958K	$13.9M
Dimensional Fund Advisors LP	+263K +60.9%	695K	$10.1M
Vanguard Capital Management LLC Index funds	+221K +16.4%	1.6M	$22.7M
Eversept Partners, LP Hedge fund	+190K New position	190K	$2.7M
Kvp Capital Advisors, LP	+185K New position	185K	$2.7M
Prudential Financial Inc	+178K +389.3%	224K	$3.2M
J. Goldman & Co LP Hedge fund	+177K New position	177K	$2.6M
Goldman Sachs Group Inc	+152K +30.1%	657K	$9.5M
Acuta Capital Partners, LLC	+137K +93.7%	283K	$4.1M
Vanguard Portfolio Management LLC Index funds	+113K +81.5%	251K	$3.6M

Biggest buyers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
Logos Global Management LP Hedge fund	+1.1M +53.8%	3.0M	$43.4M
Driehaus Capital Management LLC Active manager	+916K +52.5%	2.7M	$38.5M
Qube Research & Technologies Ltd Hedge fund	+403K +1178.6%	437K	$6.3M
Jacobs Levy Equity Management, Inc Active manager	+276K +95.4%	566K	$8.2M
Eversept Partners, LP Hedge fund	+190K New position	190K	$2.7M
J. Goldman & Co LP Hedge fund	+177K New position	177K	$2.6M
Kennedy Capital Management LLC Active manager	+112K +41.4%	384K	$5.6M
Balyasny Asset Management L.P. Hedge fund	+111K New position	111K	$1.6M
Baker Bros. Advisors LP Hedge fund	+92K +3.6%	2.7M	$38.8M
Algert Global LLC Hedge fund	+91K +44.6%	296K	$4.3M

Biggest sellers

by change in shares held

Biggest sellers
Institution	Change in shares	Shares June 30, 2026	Value
RA Capital Management, L.P. Hedge fund	−3.0M Sold out	0	—
Kynam Capital Management, LP Hedge fund	−785K Sold out	0	—
Almitas Capital LLC	−503K −32.9%	1.0M	$14.9M
Point72 Asset Management, L.P. Hedge fund	−356K −13.1%	2.4M	$34.2M
D. E. Shaw & Co., Inc. Hedge fund	−275K −58.4%	196K	$2.8M
Woodline Partners LP Hedge fund	−261K −27.2%	700K	$10.1M
Marshall Wace, LLP Hedge fund	−151K Sold out	0	—
Citadel Advisors LLC Hedge fund	−150K −64.6%	82K	$1.2M
Invesco Ltd.	−120K −84.9%	21K	$310,078
Lynx1 Capital Management LP	−120K Sold out	0	—
Sei Investments Co	−110K −82.9%	23K	$329,053
Jane Street Group, LLC	−104K Sold out	0	—
Elmind Capital, LP	−100K −48.1%	108K	$1.6M
Trexquant Investment LP Hedge fund	−89K −76.0%	28K	$407,331
Acadian Asset Management LLC Active manager	−79K −12.8%	537K	$7.8M
Informed Momentum Co LLC	−79K Sold out	0	—
Squarepoint Ops LLC Hedge fund	−56K −65.6%	30K	$428,746
Verdad Advisers, LP	−45K −48.5%	48K	$688,150
BNP Paribas Financial Markets	−45K −88.6%	5,751	$83,217
Barclays PLC	−44K −79.0%	12K	$169,401

Biggest sellers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
RA Capital Management, L.P. Hedge fund	−3.0M Sold out	0	—
Kynam Capital Management, LP Hedge fund	−785K Sold out	0	—
Point72 Asset Management, L.P. Hedge fund	−356K −13.1%	2.4M	$34.2M
D. E. Shaw & Co., Inc. Hedge fund	−275K −58.4%	196K	$2.8M
Woodline Partners LP Hedge fund	−261K −27.2%	700K	$10.1M
Marshall Wace, LLP Hedge fund	−151K Sold out	0	—
Citadel Advisors LLC Hedge fund	−150K −64.6%	82K	$1.2M
Trexquant Investment LP Hedge fund	−89K −76.0%	28K	$407,331
Acadian Asset Management LLC Active manager	−79K −12.8%	537K	$7.8M
Squarepoint Ops LLC Hedge fund	−56K −65.6%	30K	$428,746

New positions

largest by value

Institution	Shares	Value June 30, 2026
Frazier Life Sciences Management, L.P.	1.8M	$26.2M
Sofinnova Investments, Inc.	865K	$12.5M
Siren, L.L.C.	523K	$7.6M
Eversept Partners, LPHedge fund	190K	$2.7M
Kvp Capital Advisors, LP	185K	$2.7M
J. Goldman & Co LPHedge fund	177K	$2.6M
Balyasny Asset Management L.P.Hedge fund	111K	$1.6M
Dafna Capital Management LLC	103K	$1.5M
Summittx Capital, L.P.	81K	$1.2M
Exoduspoint Capital Management, LPHedge fund	41K	$597,408

Sold out

largest by value

Institution	Shares	Value March 31, 2026
RA Capital Management, L.P.Hedge fund	3.0M	$31.6M
Kynam Capital Management, LPHedge fund	785K	$8.3M
Marshall Wace, LLPHedge fund	151K	$1.6M
Lynx1 Capital Management LP	120K	$1.3M
Jane Street Group, LLC	104K	$1.1M
Informed Momentum Co LLC	79K	$840,017
Velan Capital Investment Management LP	20K	$212,800
Engineers Gate Manager LPHedge fund	16K	$171,198
Brevan Howard Capital Management LPHedge fund	15K	$162,728
Dynamic Technology Lab Private Ltd	15K	$156,929

Who holds the shares

13F holdings at June 30, 2026

Institutions reporting: 136
Ten largest holders: 62.1%
Index fund managers: 16.3%
Active managers and hedge funds: 37.2%

Buying and selling by type of institution, March 31, 2026 to June 30, 2026
Type	Bought	Sold	New	Sold out	Net change in shares	Net %
Active managers and hedge funds	17	17	5	6	−1.7M	−9.5%
Index fund managers	9	0	0	0	+1.3M	+23.0%
Other institutions	64	31	23	10	+5.7M	+39.3%

Active managers and hedge funds: a list we maintain of about 400 well-known stock-picking firms and hedge funds, matched by SEC registration number (CIK) and checked against the filer names each quarter. Index fund managers: the large index houses, such as BlackRock, Vanguard, State Street, Geode and Northern Trust. Every other filer (banks, brokers, wealth managers, pension funds, insurers and firms not on the list) counts as another institution. A firm that files under several SEC registrations appears once for each.

What these filings can and cannot tell you

Form 13F lists the long positions in US-listed shares held by investment managers with more than $100 million in such holdings. Managers file it up to 45 days after each quarter ends, so this page shows what funds held at the end of each quarter, not what they are doing now: a position may have changed since. Short positions, most derivatives and smaller managers are not included, and a cut can mean a fund lost clients or rebalanced rather than a view on Design Therapeutics.

Only managers that filed a holdings report for both quarters are compared (151 here). 2 other holders are left out: first-time or late filers, firms that changed their SEC registration, and filings that withheld positions under confidential treatment, any of which would otherwise look like a new position or a sale. Figures are as reported by each manager in the SEC's quarterly 13F data sets; option positions are excluded.

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