Ionis Pharmaceuticals Inc: which funds bought and sold
Institutions that bought and sold Ionis Pharmaceuticals shares in Q2 2026, from the holdings they reported to the SEC on Form 13F for March 31, 2026 and June 30, 2026.
Between March 31, 2026 and June 30, 2026, 260 institutions that filed 13F reports for both quarters added to or opened positions in Ionis Pharmaceuticals, and 204 cut or closed them. Together they added a net 6.9M shares, +4.0% on what they held at the start of the quarter. Active managers and hedge funds on our list were net buyers of 2.1M shares (+2.3%); index fund managers were net buyers of 416K shares (+1.1%). 60 opened a new position and 45 sold out entirely.
Bought, Q2 2026 260 institutions, 60 of them new holders Sold, Q2 2026 204 institutions, 45 of them sold out
Net change, all compared +6.9M shares (+4.0%)
Net change, active managers +2.1M shares (+2.3%), 42 bought, 34 sold
Buyers versus sellers
260 bought 85 204 sold
Active managers and hedge funds 42 bought · 34 sold · +2.1M
Index fund managers 8 bought · 4 sold · +416K
Other institutions 210 bought · 166 sold · +4.4M
Biggest buyers
| Institution | Change in shares | Shares June 30, 2026 | Value |
|---|---|---|---|
| Royal Bank Of Canada | +2.4M +62.6% | 6.2M | $490M |
| Barclays PLC | +1.3M +453.0% | 1.6M | $127M |
| Wellington Management Group LLP Active manager | +1.3M +19.7% | 7.7M | $607M |
| Alyeska Investment Group, L.P. Hedge fund | +945K +199.7% | 1.4M | $112M |
| Capital International Investors Active manager | +824K New position | 824K | $65.3M |
| Polar Capital Holdings PLC Active manager | +625K +75.3% | 1.5M | $115M |
| Artisan Partners Limited Partnership Active manager | +582K +28.3% | 2.6M | $209M |
| Nomura Asset Management International Inc. | +515K +65.6% | 1.3M | $103M |
| Capital World Investors Active manager | +483K +2.3% | 21.7M | $1.7B |
| Davern Capital Partners, LP | +412K +106.4% | 799K | $63.3M |
| Goldman Sachs Group Inc | +410K +24.1% | 2.1M | $167M |
| Two Sigma Investments, LP Hedge fund | +395K +6.7% | 6.3M | $496M |
| Freestone Grove Partners LP Hedge fund | +340K New position | 340K | $27M |
| State Street Corp Index funds | +339K +8.5% | 4.3M | $344M |
| Timessquare Capital Management, LLC | +338K +122.8% | 614K | $48.7M |
| Jane Street Group, LLC | +312K +162.6% | 504K | $39.9M |
| Jpmorgan Chase & Co | +308K +13.0% | 2.7M | $216M |
| Qube Research & Technologies Ltd Hedge fund | +291K +679.2% | 334K | $26.5M |
| Nomura Holdings Inc | +288K +252.6% | 402K | $31.9M |
| American Century Companies Inc Active manager | +283K +17.0% | 1.9M | $154M |
| Institution | Change in shares | Shares June 30, 2026 | Value |
|---|---|---|---|
| Wellington Management Group LLP Active manager | +1.3M +19.7% | 7.7M | $607M |
| Alyeska Investment Group, L.P. Hedge fund | +945K +199.7% | 1.4M | $112M |
| Capital International Investors Active manager | +824K New position | 824K | $65.3M |
| Polar Capital Holdings PLC Active manager | +625K +75.3% | 1.5M | $115M |
| Artisan Partners Limited Partnership Active manager | +582K +28.3% | 2.6M | $209M |
| Capital World Investors Active manager | +483K +2.3% | 21.7M | $1.7B |
| Two Sigma Investments, LP Hedge fund | +395K +6.7% | 6.3M | $496M |
| Freestone Grove Partners LP Hedge fund | +340K New position | 340K | $27M |
| Qube Research & Technologies Ltd Hedge fund | +291K +679.2% | 334K | $26.5M |
| American Century Companies Inc Active manager | +283K +17.0% | 1.9M | $154M |
Biggest sellers
| Institution | Change in shares | Shares June 30, 2026 | Value |
|---|---|---|---|
| T. Rowe Price Investment Management, Inc. Active manager | −2.2M −35.7% | 4.0M | $314M |
| Bellevue Group AG | −846K −46.5% | 972K | $77.1M |
| Millennium Management LLC Hedge fund | −763K −72.5% | 289K | $22.9M |
| Citadel Advisors LLC Hedge fund | −706K −74.9% | 236K | $18.7M |
| Summit Partners Public Asset Management, LLC | −617K −43.9% | 787K | $62.4M |
| Ameriprise Financial Inc | −592K −89.7% | 68K | $5.4M |
| Squarepoint Ops LLC Hedge fund | −586K −84.3% | 109K | $8.7M |
| Geode Capital Management, LLC Index funds | −400K −10.0% | 3.6M | $295M |
| Zurich Insurance Group Ltd | −240K Sold out | 0 | — |
| J. Goldman & Co LP Hedge fund | −195K −82.8% | 40K | $3.2M |
| Exoduspoint Capital Management, LP Hedge fund | −191K −84.3% | 36K | $2.8M |
| Connor, Clark & Lunn Investment Management Ltd. | −190K −21.7% | 684K | $54.3M |
| TD Asset Management Inc | −189K −35.7% | 341K | $27M |
| UBS Group AG | −184K −22.7% | 625K | $49.5M |
| Dimensional Fund Advisors LP | −182K −68.3% | 85K | $6.7M |
| Trexquant Investment LP Hedge fund | −182K −85.2% | 32K | $2.5M |
| BNP Paribas Asset Management Holding S.A. | −173K −19.1% | 734K | $58.2M |
| Invesco Ltd. | −157K −12.3% | 1.1M | $88.9M |
| Hudson Bay Capital Management LP Hedge fund | −150K −50.9% | 145K | $11.5M |
| D. E. Shaw & Co., Inc. Hedge fund | −133K −30.9% | 297K | $23.6M |
| Institution | Change in shares | Shares June 30, 2026 | Value |
|---|---|---|---|
| T. Rowe Price Investment Management, Inc. Active manager | −2.2M −35.7% | 4.0M | $314M |
| Millennium Management LLC Hedge fund | −763K −72.5% | 289K | $22.9M |
| Citadel Advisors LLC Hedge fund | −706K −74.9% | 236K | $18.7M |
| Squarepoint Ops LLC Hedge fund | −586K −84.3% | 109K | $8.7M |
| J. Goldman & Co LP Hedge fund | −195K −82.8% | 40K | $3.2M |
| Exoduspoint Capital Management, LP Hedge fund | −191K −84.3% | 36K | $2.8M |
| Trexquant Investment LP Hedge fund | −182K −85.2% | 32K | $2.5M |
| Hudson Bay Capital Management LP Hedge fund | −150K −50.9% | 145K | $11.5M |
| D. E. Shaw & Co., Inc. Hedge fund | −133K −30.9% | 297K | $23.6M |
| Engineers Gate Manager LP Hedge fund | −119K −88.9% | 15K | $1.2M |
New positions
| Institution | Shares | Value June 30, 2026 |
|---|---|---|
| Capital International InvestorsActive manager | 824K | $65.3M |
| Freestone Grove Partners LPHedge fund | 340K | $27M |
| Life Cycle Investment Partners Ltd | 220K | $17.4M |
| Eagle Health Investments LP | 195K | $15.4M |
| Bank Of Nova Scotia | 69K | $5.4M |
| Y-Intercept (Hong Kong) Ltd | 67K | $5.3M |
| Schroder Investment Management GroupActive manager | 59K | $4.7M |
| Sovran Advisors, LLC | 85K | $4.7M |
| Ethic Inc. | 32K | $2.5M |
| Jupiter Asset Management LtdActive manager | 26K | $2.1M |
Sold out
| Institution | Shares | Value March 31, 2026 |
|---|---|---|
| Zurich Insurance Group Ltd | 240K | $18M |
| Ikarian Capital, LLC | 127K | $9.5M |
| Integral Health Asset Management, LLC | 125K | $9.4M |
| Winton Group LtdHedge fund | 107K | $8M |
| Lisanti Capital Growth, LLC | 76K | $5.7M |
| Stempoint Capital LP | 53K | $4M |
| Tudor Investment Corp Et AlHedge fund | 48K | $3.6M |
| West Michigan Advisors, LLC | 45K | $3.4M |
| Prelude Capital Management, LLC | 30K | $2.2M |
| Florida Financial Advisors, LLC | 26K | $1.9M |
Who holds the shares
- Institutions reporting
- 511
- Ten largest holders
- 55.9% of 13F-reported shares
- Index fund managers
- 20.9% of 13F-reported shares
- Active managers and hedge funds
- 53.3% of 13F-reported shares
| Type | Bought | Sold | New | Sold out | Net change in shares | Net % |
|---|---|---|---|---|---|---|
| Active managers and hedge funds | 42 | 34 | 6 | 5 | +2.1M | +2.3% |
| Index fund managers | 8 | 4 | 0 | 0 | +416K | +1.1% |
| Other institutions | 210 | 166 | 54 | 40 | +4.4M | +10.5% |
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