Karyopharm Therapeutics Inc.: which funds bought and sold
Institutions that bought and sold Karyopharm Therapeutics shares in Q2 2026, from the holdings they reported to the SEC on Form 13F for March 31, 2026 and June 30, 2026.
Between March 31, 2026 and June 30, 2026, 64 institutions that filed 13F reports for both quarters added to or opened positions in Karyopharm Therapeutics, and 28 cut or closed them. Together they added a net 3.8M shares, +20.8% on what they held at the start of the quarter. Active managers and hedge funds on our list were net sellers of 2.3M shares (−21.4%); index fund managers were net buyers of 2.3M shares (+161.4%). 34 opened a new position and 14 sold out entirely.
Bought, Q2 2026 64 institutions, 34 of them new holders Sold, Q2 2026 28 institutions, 14 of them sold out
Net change, all compared +3.8M shares (+20.8%)
Net change, active managers −2.3M shares (−21.4%), 12 bought, 11 sold
Buyers versus sellers
64 bought 18 28 sold
Active managers and hedge funds 12 bought · 11 sold · −2.3M
Index fund managers 9 bought · 0 sold · +2.3M
Other institutions 43 bought · 17 sold · +3.7M
Biggest buyers
| Institution | Change in shares | Shares June 30, 2026 | Value |
|---|---|---|---|
| Kalehua Capital Management LLC | +1.4M New position | 1.4M | $13.4M |
| Acorn Capital Advisors, LLC | +1.2M +427.4% | 1.5M | $14.8M |
| Blackrock, Inc. Index funds | +1.2M +479.3% | 1.4M | $13.9M |
| Nea Management Company, LLC | +577K New position | 577K | $5.6M |
| Two Sigma Investments, LP Hedge fund | +544K +359.7% | 695K | $6.8M |
| Ghisallo Capital Management LLC Hedge fund | +500K New position | 500K | $4.9M |
| Goldman Sachs Group Inc | +477K +50.3% | 1.4M | $13.9M |
| Geode Capital Management, LLC Index funds | +325K +157.7% | 531K | $5.2M |
| Silverarc Capital Management, LLC | +297K New position | 297K | $2.9M |
| State Street Corp Index funds | +245K +303.7% | 326K | $3.2M |
| Vanguard Capital Management LLC Index funds | +219K +29.6% | 959K | $9.4M |
| Jpmorgan Chase & Co | +207K +43978.3% | 208K | $2.1M |
| BNP Paribas Financial Markets | +188K +223754.8% | 188K | $1.8M |
| Morgan Stanley | +184K +990.5% | 203K | $2M |
| UBS Group AG | +160K +82.2% | 354K | $3.5M |
| Barclays PLC | +158K +2134.7% | 166K | $1.6M |
| Vanguard Portfolio Management LLC Index funds | +135K New position | 135K | $1.3M |
| Northern Trust Corp Index funds | +121K +315.0% | 160K | $1.6M |
| Brevan Howard Capital Management LP Hedge fund | +97K +45.9% | 310K | $3M |
| Invesco Ltd. | +74K +439.5% | 90K | $882,270 |
| Institution | Change in shares | Shares June 30, 2026 | Value |
|---|---|---|---|
| Two Sigma Investments, LP Hedge fund | +544K +359.7% | 695K | $6.8M |
| Ghisallo Capital Management LLC Hedge fund | +500K New position | 500K | $4.9M |
| Brevan Howard Capital Management LP Hedge fund | +97K +45.9% | 310K | $3M |
| J. Goldman & Co LP Hedge fund | +68K New position | 68K | $659,475 |
| Squarepoint Ops LLC Hedge fund | +64K New position | 64K | $623,336 |
| Citadel Advisors LLC Hedge fund | +52K New position | 52K | $508,714 |
| Acadian Asset Management LLC Active manager | +50K +20.1% | 299K | $2.9M |
| Exoduspoint Capital Management, LP Hedge fund | +27K New position | 27K | $259,706 |
| Price T Rowe Associates Inc Active manager | +16K +150.1% | 27K | $266,000 |
| Quadrature Capital Ltd Hedge fund | +10K New position | 10K | $100,592 |
Biggest sellers
| Institution | Change in shares | Shares June 30, 2026 | Value |
|---|---|---|---|
| Commodore Capital LP Hedge fund | −1.9M Sold out | 0 | — |
| T. Rowe Price Investment Management, Inc. Active manager | −756K −49.0% | 786K | $7.7M |
| Ikarian Capital, LLC | −733K Sold out | 0 | — |
| Adage Capital Partners Gp, L.L.C. Hedge fund | −285K −15.8% | 1.5M | $14.9M |
| Boothbay Fund Management, LLC Hedge fund | −214K Sold out | 0 | — |
| Group One Trading LLC | −192K Sold out | 0 | — |
| Affinity Asset Advisors, LLC | −188K −37.5% | 313K | $3.1M |
| Jump Financial, LLC | −168K −64.1% | 94K | $918,380 |
| ADAR1 Capital Management, LLC Hedge fund | −137K Sold out | 0 | — |
| Millennium Management LLC Hedge fund | −115K −27.3% | 306K | $3M |
| Xtx Topco Ltd | −111K −67.6% | 53K | $520,467 |
| Engineers Gate Manager LP Hedge fund | −78K −69.8% | 34K | $331,848 |
| Jane Street Group, LLC | −73K −68.7% | 33K | $324,100 |
| Balyasny Asset Management L.P. Hedge fund | −71K Sold out | 0 | — |
| Trexquant Investment LP Hedge fund | −70K −27.0% | 188K | $1.8M |
| Tetragon Partners Gp Ltd | −53K Sold out | 0 | — |
| Dafna Capital Management LLC | −46K Sold out | 0 | — |
| Zimmer Partners, LP Hedge fund | −38K Sold out | 0 | — |
| Silverback Asset Management LLC | −35K −53.8% | 30K | $293,100 |
| Centiva Capital, LP Hedge fund | −30K Sold out | 0 | — |
| Institution | Change in shares | Shares June 30, 2026 | Value |
|---|---|---|---|
| Commodore Capital LP Hedge fund | −1.9M Sold out | 0 | — |
| T. Rowe Price Investment Management, Inc. Active manager | −756K −49.0% | 786K | $7.7M |
| Adage Capital Partners Gp, L.L.C. Hedge fund | −285K −15.8% | 1.5M | $14.9M |
| Boothbay Fund Management, LLC Hedge fund | −214K Sold out | 0 | — |
| ADAR1 Capital Management, LLC Hedge fund | −137K Sold out | 0 | — |
| Millennium Management LLC Hedge fund | −115K −27.3% | 306K | $3M |
| Engineers Gate Manager LP Hedge fund | −78K −69.8% | 34K | $331,848 |
| Balyasny Asset Management L.P. Hedge fund | −71K Sold out | 0 | — |
| Trexquant Investment LP Hedge fund | −70K −27.0% | 188K | $1.8M |
| Zimmer Partners, LP Hedge fund | −38K Sold out | 0 | — |
New positions
| Institution | Shares | Value June 30, 2026 |
|---|---|---|
| Kalehua Capital Management LLC | 1.4M | $13.4M |
| Nea Management Company, LLC | 577K | $5.6M |
| Ghisallo Capital Management LLCHedge fund | 500K | $4.9M |
| Silverarc Capital Management, LLC | 297K | $2.9M |
| Vanguard Portfolio Management LLCIndex funds | 135K | $1.3M |
| J. Goldman & Co LPHedge fund | 68K | $659,475 |
| Squarepoint Ops LLCHedge fund | 64K | $623,336 |
| Citadel Advisors LLCHedge fund | 52K | $508,714 |
| Nuveen, LLC | 38K | $369,971 |
| Nomura Asset Management International Inc. | 33K | $326,000 |
Sold out
| Institution | Shares | Value March 31, 2026 |
|---|---|---|
| Commodore Capital LPHedge fund | 1.9M | $10.9M |
| Ikarian Capital, LLC | 733K | $4.1M |
| Boothbay Fund Management, LLCHedge fund | 214K | $1.2M |
| Group One Trading LLC | 192K | $1.1M |
| ADAR1 Capital Management, LLCHedge fund | 137K | $761,620 |
| Balyasny Asset Management L.P.Hedge fund | 71K | $394,066 |
| Tetragon Partners Gp Ltd | 53K | $295,121 |
| Dafna Capital Management LLC | 46K | $255,106 |
| Zimmer Partners, LPHedge fund | 38K | $208,875 |
| Centiva Capital, LPHedge fund | 30K | $168,270 |
Who holds the shares
- Institutions reporting
- 96
- Ten largest holders
- 58.6% of 13F-reported shares
- Index fund managers
- 17.3% of 13F-reported shares
- Active managers and hedge funds
- 38.7% of 13F-reported shares
| Type | Bought | Sold | New | Sold out | Net change in shares | Net % |
|---|---|---|---|---|---|---|
| Active managers and hedge funds | 12 | 11 | 6 | 6 | −2.3M | −21.4% |
| Index fund managers | 9 | 0 | 2 | 0 | +2.3M | +161.4% |
| Other institutions | 43 | 17 | 26 | 8 | +3.7M | +63.7% |
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