Lexicon Pharmaceuticals, Inc.: which funds bought and sold

Institutions that bought and sold Lexicon Pharmaceuticals shares in Q2 2026, from the holdings they reported to the SEC on Form 13F for March 31, 2026 and June 30, 2026.

Between March 31, 2026 and June 30, 2026, 80 institutions that filed 13F reports for both quarters added to or opened positions in Lexicon Pharmaceuticals, and 66 cut or closed them. Together they added a net 41.3M shares, +12.8% on what they held at the start of the quarter. Active managers and hedge funds on our list were net buyers of 1.3M shares (+1.5%); index fund managers were net buyers of 26.0M shares (+125.5%). 44 opened a new position and 30 sold out entirely.

Bought, Q2 2026 80 institutions, 44 of them new holders Sold, Q2 2026 66 institutions, 30 of them sold out

Net change, all compared +41.3M shares (+12.8%)

Net change, active managers +1.3M shares (+1.5%), 17 bought, 15 sold

Buyers versus sellers

institutions compared, 177

80 bought 31 66 sold

Active managers and hedge funds 17 bought · 15 sold · +1.3M

Index fund managers 11 bought · 1 sold · +26.0M

Other institutions 52 bought · 50 sold · +14.0M

Biggest buyers

by change in shares held

Biggest buyers
Institution	Change in shares	Shares June 30, 2026	Value
Artal Group S.A.	+20.4M +13.2%	175.2M	$420M
Blackrock, Inc. Index funds	+14.0M +422.2%	17.3M	$41.6M
FMR LLC Active manager	+6.7M +14.9%	51.8M	$124M
State Street Corp Index funds	+4.0M +410.1%	4.9M	$11.8M
Geode Capital Management, LLC Index funds	+3.1M +97.0%	6.2M	$15M
Vanguard Portfolio Management LLC Index funds	+1.8M +331.3%	2.4M	$5.7M
Northern Trust Corp Index funds	+1.5M +298.0%	2.0M	$4.7M
Sessa Capital Im, L.P. Hedge fund	+1.0M +5.8%	19.0M	$45.5M
Charles Schwab Investment Management Inc Index funds	+645K +49.2%	2.0M	$4.7M
Nuveen, LLC	+587K New position	587K	$1.4M
Bank Of New York Mellon Corp	+541K +1971.1%	569K	$1.4M
Citadel Advisors LLC Hedge fund	+506K +46.2%	1.6M	$3.8M
Point72 Asset Management, L.P. Hedge fund	+437K +5.6%	8.3M	$19.8M
Vanguard Capital Management LLC Index funds	+382K +4.0%	9.9M	$23.8M
Ishara Investments LP	+369K +40.9%	1.3M	$3.1M
Vanguard Fiduciary Trust Co Index funds	+302K +22.7%	1.6M	$3.9M
Janney Montgomery Scott LLC	+296K New position	296K	$709,000
Barclays PLC	+282K +267.3%	387K	$929,960
Canada Pension Plan Investment Board	+258K New position	258K	$618,960
Rhumbline Advisers Index funds	+257K New position	257K	$616,523

Biggest buyers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
FMR LLC Active manager	+6.7M +14.9%	51.8M	$124M
Sessa Capital Im, L.P. Hedge fund	+1.0M +5.8%	19.0M	$45.5M
Citadel Advisors LLC Hedge fund	+506K +46.2%	1.6M	$3.8M
Point72 Asset Management, L.P. Hedge fund	+437K +5.6%	8.3M	$19.8M
Acadian Asset Management LLC Active manager	+251K +56.4%	697K	$1.7M
Price T Rowe Associates Inc Active manager	+204K New position	204K	$491,000
Wellington Management Group LLP Active manager	+180K New position	180K	$431,280
Panagora Asset Management Inc Active manager	+132K New position	132K	$316,901
Algert Global LLC Hedge fund	+92K New position	92K	$221,160
Alliancebernstein L.P. Active manager	+68K New position	68K	$105,768

Biggest sellers

by change in shares held

Biggest sellers
Institution	Change in shares	Shares June 30, 2026	Value
Millennium Management LLC Hedge fund	−3.8M −77.1%	1.1M	$2.7M
Jane Street Group, LLC	−2.7M Sold out	0	—
Marshall Wace, LLP Hedge fund	−2.4M Sold out	0	—
UBS Group AG	−1.8M −72.4%	685K	$1.6M
CIBC Bancorp Usa Inc.	−1.8M −99.2%	14K	$32,976
Susquehanna International Group, LLP	−1.4M −67.2%	697K	$1.7M
Hennion & Walsh Asset Management, Inc.	−848K Sold out	0	—
Goldman Sachs Group Inc	−585K −54.6%	486K	$1.2M
Two Sigma Investments, LP Hedge fund	−556K −46.4%	643K	$1.5M
Gsa Capital Partners LLP	−533K −57.3%	397K	$953,000
Renaissance Technologies LLC Hedge fund	−474K −29.6%	1.1M	$2.7M
Tang Capital Management LLC Hedge fund	−400K Sold out	0	—
Catalyst Funds Management Pty Ltd	−208K Sold out	0	—
Brevan Howard Capital Management LP Hedge fund	−160K Sold out	0	—
Jain Global LLC Hedge fund	−155K Sold out	0	—
Hudson Bay Capital Management LP Hedge fund	−153K Sold out	0	—
Jacobs Levy Equity Management, Inc Active manager	−130K Sold out	0	—
HRT Financial LP	−123K Sold out	0	—
Scotia Capital Inc.	−111K −69.4%	49K	$117,291
Man Group PLC Hedge fund	−109K Sold out	0	—

Biggest sellers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
Millennium Management LLC Hedge fund	−3.8M −77.1%	1.1M	$2.7M
Marshall Wace, LLP Hedge fund	−2.4M Sold out	0	—
Two Sigma Investments, LP Hedge fund	−556K −46.4%	643K	$1.5M
Renaissance Technologies LLC Hedge fund	−474K −29.6%	1.1M	$2.7M
Tang Capital Management LLC Hedge fund	−400K Sold out	0	—
Brevan Howard Capital Management LP Hedge fund	−160K Sold out	0	—
Jain Global LLC Hedge fund	−155K Sold out	0	—
Hudson Bay Capital Management LP Hedge fund	−153K Sold out	0	—
Jacobs Levy Equity Management, Inc Active manager	−130K Sold out	0	—
Man Group PLC Hedge fund	−109K Sold out	0	—

New positions

largest by value

Institution	Shares	Value June 30, 2026
Nuveen, LLC	587K	$1.4M
Janney Montgomery Scott LLC	296K	$709,000
Canada Pension Plan Investment Board	258K	$618,960
Rhumbline AdvisersIndex funds	257K	$616,523
Deutsche Bank Ag\	248K	$594,068
Price T Rowe Associates IncActive manager	204K	$491,000
Wellington Management Group LLPActive manager	180K	$431,280
Virtus Investment Advisers, LLC	170K	$408,996
Metlife Investment Management, LLC	146K	$351,384
Panagora Asset Management IncActive manager	132K	$316,901

Sold out

largest by value

Institution	Shares	Value March 31, 2026
Jane Street Group, LLC	2.7M	$4.2M
Marshall Wace, LLPHedge fund	2.4M	$3.7M
Hennion & Walsh Asset Management, Inc.	848K	$1.3M
Tang Capital Management LLCHedge fund	400K	$623,532
Catalyst Funds Management Pty Ltd	208K	$324,324
Brevan Howard Capital Management LPHedge fund	160K	$250,378
Jain Global LLCHedge fund	155K	$241,488
Hudson Bay Capital Management LPHedge fund	153K	$238,081
Jacobs Levy Equity Management, IncActive manager	130K	$202,831
Bridgewater Advisors Inc.	82K	$200,590

Who holds the shares

13F holdings at June 30, 2026

Institutions reporting: 148
Ten largest holders: 93.0%
Index fund managers: 12.8%
Active managers and hedge funds: 23.6%

Buying and selling by type of institution, March 31, 2026 to June 30, 2026
Type	Bought	Sold	New	Sold out	Net change in shares	Net %
Active managers and hedge funds	17	15	9	8	+1.3M	+1.5%
Index fund managers	11	1	3	0	+26.0M	+125.5%
Other institutions	52	50	32	22	+14.0M	+6.4%

Active managers and hedge funds: a list we maintain of about 400 well-known stock-picking firms and hedge funds, matched by SEC registration number (CIK) and checked against the filer names each quarter. Index fund managers: the large index houses, such as BlackRock, Vanguard, State Street, Geode and Northern Trust. Every other filer (banks, brokers, wealth managers, pension funds, insurers and firms not on the list) counts as another institution. A firm that files under several SEC registrations appears once for each.

What these filings can and cannot tell you

Form 13F lists the long positions in US-listed shares held by investment managers with more than $100 million in such holdings. Managers file it up to 45 days after each quarter ends, so this page shows what funds held at the end of each quarter, not what they are doing now: a position may have changed since. Short positions, most derivatives and smaller managers are not included, and a cut can mean a fund lost clients or rebalanced rather than a view on Lexicon Pharmaceuticals.

Only managers that filed a holdings report for both quarters are compared (177 here). 3 other holders are left out: first-time or late filers, firms that changed their SEC registration, and filings that withheld positions under confidential treatment, any of which would otherwise look like a new position or a sale. Figures are as reported by each manager in the SEC's quarterly 13F data sets; option positions are excluded.

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