Prelude Therapeutics Inc: which funds bought and sold

Institutions that bought and sold Prelude Therapeutics shares in Q2 2026, from the holdings they reported to the SEC on Form 13F for March 31, 2026 and June 30, 2026.

Between March 31, 2026 and June 30, 2026, 59 institutions that filed 13F reports for both quarters added to or opened positions in Prelude Therapeutics, and 21 cut or closed them. Together they added a net 18.8M shares, +61.2% on what they held at the start of the quarter. Active managers and hedge funds on our list were net buyers of 11.8M shares (+76.0%); index fund managers were net buyers of 3.7M shares (+167.5%). 34 opened a new position and 13 sold out entirely.

Bought, Q2 2026 59 institutions, 34 of them new holders Sold, Q2 2026 21 institutions, 13 of them sold out

Net change, all compared +18.8M shares (+61.2%)

Net change, active managers +11.8M shares (+76.0%), 18 bought, 7 sold

Buyers versus sellers

institutions compared, 88

59 bought 8 21 sold

Active managers and hedge funds 18 bought · 7 sold · +11.8M

Index fund managers 9 bought · 0 sold · +3.7M

Other institutions 32 bought · 14 sold · +3.4M

Biggest buyers

by change in shares held

Biggest buyers
Institution	Change in shares	Shares June 30, 2026	Value
RA Capital Management, L.P. Hedge fund	+6.5M New position	6.5M	$34.5M
Soleus Capital Management, L.P. Hedge fund	+3.4M New position	3.4M	$18M
Orbimed Advisors LLC	+2.8M +25.8%	13.7M	$73.2M
Blackrock, Inc. Index funds	+1.5M +458.4%	1.8M	$9.6M
Kynam Capital Management, LP Hedge fund	+823K +51.6%	2.4M	$12.9M
Vanguard Capital Management LLC Index funds	+779K +63.3%	2.0M	$10.7M
Adage Capital Partners Gp, L.L.C. Hedge fund	+766K New position	766K	$4.1M
ADAR1 Capital Management, LLC Hedge fund	+748K +489.5%	901K	$4.8M
Geode Capital Management, LLC Index funds	+539K +178.3%	842K	$4.5M
Millennium Management LLC Hedge fund	+462K +120.8%	845K	$4.5M
Sphera Funds Management Ltd.	+461K +82.7%	1.0M	$5.4M
State Street Corp Index funds	+291K +210.2%	429K	$2.3M
UBS Group AG	+254K +394.2%	319K	$1.7M
Vanguard Portfolio Management LLC Index funds	+194K New position	194K	$1M
Northern Trust Corp Index funds	+190K +380.0%	241K	$1.3M
Morgan Stanley	+182K +56.4%	504K	$2.7M
Vanguard Fiduciary Trust Co Index funds	+128K +81.0%	285K	$1.5M
Acadian Asset Management LLC Active manager	+100K +19.5%	611K	$3.3M
Hillsdale Investment Management Inc.	+81K New position	81K	$433,862
Two Sigma Investments, LP Hedge fund	+70K +7.6%	993K	$5.3M

Biggest buyers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
RA Capital Management, L.P. Hedge fund	+6.5M New position	6.5M	$34.5M
Soleus Capital Management, L.P. Hedge fund	+3.4M New position	3.4M	$18M
Kynam Capital Management, LP Hedge fund	+823K +51.6%	2.4M	$12.9M
Adage Capital Partners Gp, L.L.C. Hedge fund	+766K New position	766K	$4.1M
ADAR1 Capital Management, LLC Hedge fund	+748K +489.5%	901K	$4.8M
Millennium Management LLC Hedge fund	+462K +120.8%	845K	$4.5M
Acadian Asset Management LLC Active manager	+100K +19.5%	611K	$3.3M
Two Sigma Investments, LP Hedge fund	+70K +7.6%	993K	$5.3M
Squarepoint Ops LLC Hedge fund	+60K New position	60K	$317,348
Panagora Asset Management Inc Active manager	+48K New position	48K	$253,569

Biggest sellers

by change in shares held

Biggest sellers
Institution	Change in shares	Shares June 30, 2026	Value
Ecor1 Capital, LLC Hedge fund	−947K Sold out	0	—
Susquehanna International Group, LLP	−268K Sold out	0	—
Jane Street Group, LLC	−193K Sold out	0	—
Marshall Wace, LLP Hedge fund	−168K −46.9%	191K	$1M
Goldman Sachs Group Inc	−116K −48.9%	121K	$644,045
Citadel Advisors LLC Hedge fund	−102K −81.9%	23K	$120,213
HRT Financial LP	−59K Sold out	0	—
Xtx Topco Ltd	−57K Sold out	0	—
Focus Partners Wealth	−50K Sold out	0	—
Omers Administration Corp	−33K Sold out	0	—
Bank Of America Corp	−33K −57.8%	24K	$127,254
Prudential Financial Inc	−17K Sold out	0	—
Point72 Asset Management, L.P. Hedge fund	−16K Sold out	0	—
Diametric Capital, LP	−12K Sold out	0	—
Nine Masts Capital Ltd	−12K Sold out	0	—
American Century Companies Inc Active manager	−10K Sold out	0	—
Qube Research & Technologies Ltd Hedge fund	−3,307 −20.1%	13K	$69,876
Sbi Securities Co., Ltd.	−2,619 −99.2%	22	$117
Caldwell Sutter Capital, Inc.	−1,000 Sold out	0	—
FMR LLC Active manager	−380 −6.3%	5,629	$30,003

Biggest sellers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
Ecor1 Capital, LLC Hedge fund	−947K Sold out	0	—
Marshall Wace, LLP Hedge fund	−168K −46.9%	191K	$1M
Citadel Advisors LLC Hedge fund	−102K −81.9%	23K	$120,213
Point72 Asset Management, L.P. Hedge fund	−16K Sold out	0	—
American Century Companies Inc Active manager	−10K Sold out	0	—
Qube Research & Technologies Ltd Hedge fund	−3,307 −20.1%	13K	$69,876
FMR LLC Active manager	−380 −6.3%	5,629	$30,003

New positions

largest by value

Institution	Shares	Value June 30, 2026
RA Capital Management, L.P.Hedge fund	6.5M	$34.5M
Soleus Capital Management, L.P.Hedge fund	3.4M	$18M
Adage Capital Partners Gp, L.L.C.Hedge fund	766K	$4.1M
Vanguard Portfolio Management LLCIndex funds	194K	$1M
Hillsdale Investment Management Inc.	81K	$433,862
Bank Of New York Mellon Corp	68K	$363,436
Charles Schwab Investment Management IncIndex funds	68K	$360,425
Squarepoint Ops LLCHedge fund	60K	$317,348
Panagora Asset Management IncActive manager	48K	$253,569
Mariner, LLC	45K	$241,241

Sold out

largest by value

Institution	Shares	Value March 31, 2026
Ecor1 Capital, LLCHedge fund	947K	$3.2M
Susquehanna International Group, LLP	268K	$915,835
Jane Street Group, LLC	193K	$659,933
HRT Financial LP	59K	$200,000
Xtx Topco Ltd	57K	$195,590
Focus Partners Wealth	50K	$171,024
Omers Administration Corp	33K	$111,834
Prudential Financial Inc	17K	$59,576
Point72 Asset Management, L.P.Hedge fund	16K	$55,845
Diametric Capital, LP	12K	$40,971

Who holds the shares

13F holdings at June 30, 2026

Institutions reporting: 75
Ten largest holders: 86.4%
Index fund managers: 11.9%
Active managers and hedge funds: 55.0%

Buying and selling by type of institution, March 31, 2026 to June 30, 2026
Type	Bought	Sold	New	Sold out	Net change in shares	Net %
Active managers and hedge funds	18	7	10	3	+11.8M	+76.0%
Index fund managers	9	0	3	0	+3.7M	+167.5%
Other institutions	32	14	21	10	+3.4M	+25.7%

Active managers and hedge funds: a list we maintain of about 400 well-known stock-picking firms and hedge funds, matched by SEC registration number (CIK) and checked against the filer names each quarter. Index fund managers: the large index houses, such as BlackRock, Vanguard, State Street, Geode and Northern Trust. Every other filer (banks, brokers, wealth managers, pension funds, insurers and firms not on the list) counts as another institution. A firm that files under several SEC registrations appears once for each.

What these filings can and cannot tell you

Form 13F lists the long positions in US-listed shares held by investment managers with more than $100 million in such holdings. Managers file it up to 45 days after each quarter ends, so this page shows what funds held at the end of each quarter, not what they are doing now: a position may have changed since. Short positions, most derivatives and smaller managers are not included, and a cut can mean a fund lost clients or rebalanced rather than a view on Prelude Therapeutics.

Only managers that filed a holdings report for both quarters are compared (88 here). 1 other holder is left out: first-time or late filers, firms that changed their SEC registration, and filings that withheld positions under confidential treatment, any of which would otherwise look like a new position or a sale. Figures are as reported by each manager in the SEC's quarterly 13F data sets; option positions are excluded.

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