Spyre Therapeutics, Inc.: which funds bought and sold
Institutions that bought and sold Spyre Therapeutics shares in Q2 2026, from the holdings they reported to the SEC on Form 13F for March 31, 2026 and June 30, 2026.
Between March 31, 2026 and June 30, 2026, 192 institutions that filed 13F reports for both quarters added to or opened positions in Spyre Therapeutics, and 76 cut or closed them. Together they added a net 12.4M shares, +15.3% on what they held at the start of the quarter. Active managers and hedge funds on our list were net buyers of 5.5M shares (+13.6%); index fund managers were net buyers of 4.7M shares (+30.6%). 89 opened a new position and 21 sold out entirely.
Bought, Q2 2026 192 institutions, 89 of them new holders Sold, Q2 2026 76 institutions, 21 of them sold out
Net change, all compared +12.4M shares (+15.3%)
Net change, active managers +5.5M shares (+13.6%), 47 bought, 18 sold
Buyers versus sellers
192 bought 14 76 sold
Active managers and hedge funds 47 bought · 18 sold · +5.5M
Index fund managers 10 bought · 2 sold · +4.7M
Other institutions 135 bought · 56 sold · +2.2M
Biggest buyers
| Institution | Change in shares | Shares June 30, 2026 | Value |
|---|---|---|---|
| Paradigm Biocapital Advisors LP | +1.9M +96.2% | 3.8M | $341M |
| Vanguard Portfolio Management LLC Index funds | +1.7M +298.2% | 2.3M | $207M |
| Adage Capital Partners Gp, L.L.C. Hedge fund | +1.7M New position | 1.7M | $153M |
| Capital World Investors Active manager | +1.6M +247.4% | 2.3M | $206M |
| Price T Rowe Associates Inc Active manager | +1.4M +85.2% | 3.0M | $263M |
| FMR LLC Active manager | +1.2M +10.6% | 13.0M | $1.2B |
| Goldman Sachs Group Inc | +1.2M +447.6% | 1.5M | $131M |
| Holocene Advisors, LP Hedge fund | +1.0M New position | 1.0M | $90.1M |
| Blackrock, Inc. Index funds | +985K +17.8% | 6.5M | $578M |
| Marshall Wace, LLP Hedge fund | +852K +612.1% | 992K | $88M |
| Geode Capital Management, LLC Index funds | +841K +48.9% | 2.6M | $239M |
| Franklin Resources Inc Active manager | +590K +66.8% | 1.5M | $131M |
| Bank Of America Corp | +550K +44.8% | 1.8M | $158M |
| Perceptive Advisors LLC Hedge fund | +536K +14.2% | 4.3M | $383M |
| State Street Corp Index funds | +450K +17.3% | 3.1M | $271M |
| Vanguard Capital Management LLC Index funds | +391K +12.8% | 3.4M | $306M |
| Voya Investment Management LLC | +378K +699.9% | 432K | $38.3M |
| Integral Health Asset Management, LLC | +325K New position | 325K | $28.9M |
| UBS Am, A Distinct Business Unit Of UBS Asset Management Americas LLC | +315K +151.8% | 522K | $46.3M |
| Jennison Associates LLC Active manager | +303K New position | 303K | $26.9M |
| Institution | Change in shares | Shares June 30, 2026 | Value |
|---|---|---|---|
| Adage Capital Partners Gp, L.L.C. Hedge fund | +1.7M New position | 1.7M | $153M |
| Capital World Investors Active manager | +1.6M +247.4% | 2.3M | $206M |
| Price T Rowe Associates Inc Active manager | +1.4M +85.2% | 3.0M | $263M |
| FMR LLC Active manager | +1.2M +10.6% | 13.0M | $1.2B |
| Holocene Advisors, LP Hedge fund | +1.0M New position | 1.0M | $90.1M |
| Marshall Wace, LLP Hedge fund | +852K +612.1% | 992K | $88M |
| Franklin Resources Inc Active manager | +590K +66.8% | 1.5M | $131M |
| Perceptive Advisors LLC Hedge fund | +536K +14.2% | 4.3M | $383M |
| Jennison Associates LLC Active manager | +303K New position | 303K | $26.9M |
| Victory Capital Management Inc Active manager | +262K +89.6% | 554K | $49.2M |
Biggest sellers
| Institution | Change in shares | Shares June 30, 2026 | Value |
|---|---|---|---|
| Fairmount Funds Management LLC | −4.0M Sold out | 0 | — |
| RA Capital Management, L.P. Hedge fund | −1.6M Sold out | 0 | — |
| Commodore Capital LP Hedge fund | −1.1M −55.7% | 847K | $75.2M |
| Baker Bros. Advisors LP Hedge fund | −1.0M Sold out | 0 | — |
| Caligan Partners LP Hedge fund | −878K Sold out | 0 | — |
| Capital International Investors Active manager | −791K −45.3% | 955K | $84.8M |
| Venrock Adviser, LLC | −700K −19.0% | 3.0M | $265M |
| Wellington Management Group LLP Active manager | −243K −13.3% | 1.6M | $140M |
| Stempoint Capital LP | −228K −68.1% | 107K | $9.5M |
| Boothbay Fund Management, LLC Hedge fund | −187K −96.7% | 6,453 | $572,897 |
| Blackstone Inc. | −173K −59.0% | 120K | $10.7M |
| First Trust Advisors LP | −169K −94.5% | 9,779 | $868,179 |
| Silverarc Capital Management, LLC | −127K −67.9% | 60K | $5.3M |
| Exoduspoint Capital Management, LP Hedge fund | −87K Sold out | 0 | — |
| Highvista Strategies LLC | −68K −46.8% | 78K | $6.9M |
| Candriam S.C.A. | −64K −10.5% | 546K | $48.5M |
| Alps Advisors Inc | −64K Sold out | 0 | — |
| ADAR1 Capital Management, LLC Hedge fund | −54K −16.1% | 284K | $25.2M |
| Braidwell LP Hedge fund | −53K −5.7% | 879K | $78.1M |
| Emerald Advisers, LLC | −46K −7.5% | 567K | $50.4M |
| Institution | Change in shares | Shares June 30, 2026 | Value |
|---|---|---|---|
| RA Capital Management, L.P. Hedge fund | −1.6M Sold out | 0 | — |
| Commodore Capital LP Hedge fund | −1.1M −55.7% | 847K | $75.2M |
| Baker Bros. Advisors LP Hedge fund | −1.0M Sold out | 0 | — |
| Caligan Partners LP Hedge fund | −878K Sold out | 0 | — |
| Capital International Investors Active manager | −791K −45.3% | 955K | $84.8M |
| Wellington Management Group LLP Active manager | −243K −13.3% | 1.6M | $140M |
| Boothbay Fund Management, LLC Hedge fund | −187K −96.7% | 6,453 | $572,897 |
| Exoduspoint Capital Management, LP Hedge fund | −87K Sold out | 0 | — |
| ADAR1 Capital Management, LLC Hedge fund | −54K −16.1% | 284K | $25.2M |
| Braidwell LP Hedge fund | −53K −5.7% | 879K | $78.1M |
New positions
| Institution | Shares | Value June 30, 2026 |
|---|---|---|
| Adage Capital Partners Gp, L.L.C.Hedge fund | 1.7M | $153M |
| Holocene Advisors, LPHedge fund | 1.0M | $90.1M |
| Integral Health Asset Management, LLC | 325K | $28.9M |
| Jennison Associates LLCActive manager | 303K | $26.9M |
| Bellevue Group AG | 230K | $20.4M |
| Cormorant Asset Management, LPHedge fund | 225K | $20M |
| Eventide Asset Management, LLC | 202K | $17.9M |
| Orbimed Advisors LLC | 186K | $16.5M |
| Frontier Capital Management Co LLCActive manager | 183K | $16.2M |
| Neuberger Berman Group LLCActive manager | 181K | $16.1M |
Sold out
| Institution | Shares | Value March 31, 2026 |
|---|---|---|
| Fairmount Funds Management LLC | 4.0M | $203M |
| RA Capital Management, L.P.Hedge fund | 1.6M | $81.8M |
| Baker Bros. Advisors LPHedge fund | 1.0M | $50.4M |
| Caligan Partners LPHedge fund | 878K | $44.3M |
| Exoduspoint Capital Management, LPHedge fund | 87K | $4.4M |
| Alps Advisors Inc | 64K | $3.2M |
| Assenagon Asset Management S.A. | 19K | $940,555 |
| Carlyle Group Inc. | 9,620 | $485,233 |
| Rwc Asset Management LLP | 8,166 | $411,893 |
| Capstone Investment Advisors, LLCHedge fund | 7,537 | $380,166 |
Who holds the shares
- Institutions reporting
- 263
- Ten largest holders
- 49.3% of 13F-reported shares
- Index fund managers
- 20.8% of 13F-reported shares
- Active managers and hedge funds
- 48.3% of 13F-reported shares
| Type | Bought | Sold | New | Sold out | Net change in shares | Net % |
|---|---|---|---|---|---|---|
| Active managers and hedge funds | 47 | 18 | 25 | 5 | +5.5M | +13.6% |
| Index fund managers | 10 | 2 | 0 | 0 | +4.7M | +30.6% |
| Other institutions | 135 | 56 | 64 | 16 | +2.2M | +8.8% |