Xenon Pharmaceuticals Inc.: which funds bought and sold

Institutions that bought and sold Xenon Pharmaceuticals shares in Q2 2026, from the holdings they reported to the SEC on Form 13F for March 31, 2026 and June 30, 2026.

Between March 31, 2026 and June 30, 2026, 169 institutions that filed 13F reports for both quarters added to or opened positions in Xenon Pharmaceuticals, and 109 cut or closed them. Together they added a net 685K shares, +0.7% on what they held at the start of the quarter. Active managers and hedge funds on our list were net sellers of 3.8M shares (−6.2%); index fund managers were net buyers of 2.9M shares (+28.8%). 46 opened a new position and 22 sold out entirely.

Bought, Q2 2026 169 institutions, 46 of them new holders Sold, Q2 2026 109 institutions, 22 of them sold out

Net change, all compared +685K shares (+0.7%)

Net change, active managers −3.8M shares (−6.2%), 34 bought, 32 sold

Buyers versus sellers

institutions compared, 331

169 bought 53 109 sold

Active managers and hedge funds 34 bought · 32 sold · −3.8M

Index fund managers 9 bought · 2 sold · +2.9M

Other institutions 126 bought · 75 sold · +1.6M

Biggest buyers

by change in shares held

Biggest buyers
Institution	Change in shares	Shares June 30, 2026	Value
Price T Rowe Associates Inc Active manager	+1.9M +144.3%	3.2M	$196M
Blackrock, Inc. Index funds	+1.9M +33.4%	7.5M	$454M
T. Rowe Price Investment Management, Inc. Active manager	+1.2M +127.8%	2.2M	$131M
Two Sigma Investments, LP Hedge fund	+1.0M +171.1%	1.6M	$99.2M
Invesco Ltd.	+844K +1428.6%	903K	$54.5M
Nuveen, LLC	+743K +297.2%	993K	$59.9M
Jpmorgan Chase & Co	+694K +36.1%	2.6M	$157M
Marshall Wace, LLP Hedge fund	+689K New position	689K	$41.6M
Panagora Asset Management Inc Active manager	+664K New position	664K	$40.1M
Pictet Asset Management Holding SA	+508K +74.7%	1.2M	$71.6M
Jones Hill Capital LP	+368K New position	368K	$22.2M
Man Group PLC Hedge fund	+311K New position	311K	$18.7M
Geode Capital Management, LLC Index funds	+277K +25.4%	1.4M	$82.7M
State Street Corp Index funds	+249K +14.5%	2.0M	$119M
Ameriprise Financial Inc	+240K +303.7%	319K	$19.2M
Vanguard Portfolio Management LLC Index funds	+207K +38.0%	750K	$45.2M
American Century Companies Inc Active manager	+205K +30.2%	884K	$53.4M
D. E. Shaw & Co., Inc. Hedge fund	+205K +1082.3%	224K	$13.5M
Millennium Management LLC Hedge fund	+175K +86.7%	377K	$22.7M
Polar Capital Holdings PLC Active manager	+165K +3.8%	4.6M	$276M

Biggest buyers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
Price T Rowe Associates Inc Active manager	+1.9M +144.3%	3.2M	$196M
T. Rowe Price Investment Management, Inc. Active manager	+1.2M +127.8%	2.2M	$131M
Two Sigma Investments, LP Hedge fund	+1.0M +171.1%	1.6M	$99.2M
Marshall Wace, LLP Hedge fund	+689K New position	689K	$41.6M
Panagora Asset Management Inc Active manager	+664K New position	664K	$40.1M
Man Group PLC Hedge fund	+311K New position	311K	$18.7M
American Century Companies Inc Active manager	+205K +30.2%	884K	$53.4M
D. E. Shaw & Co., Inc. Hedge fund	+205K +1082.3%	224K	$13.5M
Millennium Management LLC Hedge fund	+175K +86.7%	377K	$22.7M
Polar Capital Holdings PLC Active manager	+165K +3.8%	4.6M	$276M

Biggest sellers

by change in shares held

Biggest sellers
Institution	Change in shares	Shares June 30, 2026	Value
Wellington Management Group LLP Active manager	−3.4M −70.5%	1.4M	$86M
Holocene Advisors, LP Hedge fund	−1.5M Sold out	0	—
Citadel Advisors LLC Hedge fund	−1.3M −47.2%	1.4M	$84.6M
FMR LLC Active manager	−1.2M −10.8%	9.6M	$582M
Jennison Associates LLC Active manager	−1.1M −84.2%	208K	$12.6M
Commodore Capital LP Hedge fund	−825K Sold out	0	—
Alyeska Investment Group, L.P. Hedge fund	−602K −46.3%	698K	$42.1M
Mpm Bioimpact LLC	−589K Sold out	0	—
Caligan Partners LP Hedge fund	−503K −36.1%	890K	$53.7M
Capital International Investors Active manager	−313K −11.7%	2.4M	$143M
Sofinnova Investments, Inc.	−305K Sold out	0	—
Fiera Capital Corp	−304K −42.8%	406K	$24.5M
Barclays PLC	−218K −91.6%	20K	$1.2M
Braidwell LP Hedge fund	−207K −15.5%	1.1M	$68.3M
Stempoint Capital LP	−205K −73.0%	76K	$4.6M
Aberdeen Group PLC	−201K −33.0%	409K	$24.7M
First Turn Management, LLC	−187K −23.7%	600K	$36.2M
Adage Capital Partners Gp, L.L.C. Hedge fund	−170K −36.2%	300K	$18.1M
Orbimed Advisors LLC	−168K −15.8%	892K	$53.9M
Susquehanna International Group, LLP	−155K −87.4%	22K	$1.3M

Biggest sellers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
Wellington Management Group LLP Active manager	−3.4M −70.5%	1.4M	$86M
Holocene Advisors, LP Hedge fund	−1.5M Sold out	0	—
Citadel Advisors LLC Hedge fund	−1.3M −47.2%	1.4M	$84.6M
FMR LLC Active manager	−1.2M −10.8%	9.6M	$582M
Jennison Associates LLC Active manager	−1.1M −84.2%	208K	$12.6M
Commodore Capital LP Hedge fund	−825K Sold out	0	—
Alyeska Investment Group, L.P. Hedge fund	−602K −46.3%	698K	$42.1M
Caligan Partners LP Hedge fund	−503K −36.1%	890K	$53.7M
Capital International Investors Active manager	−313K −11.7%	2.4M	$143M
Braidwell LP Hedge fund	−207K −15.5%	1.1M	$68.3M

New positions

largest by value

Institution	Shares	Value June 30, 2026
Marshall Wace, LLPHedge fund	689K	$41.6M
Panagora Asset Management IncActive manager	664K	$40.1M
Jones Hill Capital LP	368K	$22.2M
Man Group PLCHedge fund	311K	$18.7M
Point72 Asset Management, L.P.Hedge fund	130K	$7.9M
Squarepoint Ops LLCHedge fund	113K	$6.8M
Capital Fund Management S.A.Hedge fund	84K	$5.1M
Walleye Capital LLCHedge fund	77K	$4.6M
Royce & Associates LPActive manager	65K	$3.9M
Diversified Trust Co	39K	$2.4M

Sold out

largest by value

Institution	Shares	Value March 31, 2026
Holocene Advisors, LPHedge fund	1.5M	$88.3M
Commodore Capital LPHedge fund	825K	$48M
Mpm Bioimpact LLC	589K	$34.2M
Sofinnova Investments, Inc.	305K	$17.7M
Y-Intercept (Hong Kong) Ltd	85K	$5M
Atika Capital Management LLC	60K	$3.5M
LMR Partners LLPHedge fund	56K	$3.3M
Qube Research & Technologies LtdHedge fund	44K	$2.6M
Calamos Advisors LLCActive manager	30K	$1.8M
Summittx Capital, L.P.	26K	$1.5M

Who holds the shares

13F holdings at June 30, 2026

Institutions reporting: 314
Ten largest holders: 46.0%
Index fund managers: 12.7%
Active managers and hedge funds: 57.4%

Buying and selling by type of institution, March 31, 2026 to June 30, 2026
Type	Bought	Sold	New	Sold out	Net change in shares	Net %
Active managers and hedge funds	34	32	10	6	−3.8M	−6.2%
Index fund managers	9	2	0	0	+2.9M	+28.8%
Other institutions	126	75	36	16	+1.6M	+6.8%

Active managers and hedge funds: a list we maintain of about 400 well-known stock-picking firms and hedge funds, matched by SEC registration number (CIK) and checked against the filer names each quarter. Index fund managers: the large index houses, such as BlackRock, Vanguard, State Street, Geode and Northern Trust. Every other filer (banks, brokers, wealth managers, pension funds, insurers and firms not on the list) counts as another institution. A firm that files under several SEC registrations appears once for each.

What these filings can and cannot tell you

Form 13F lists the long positions in US-listed shares held by investment managers with more than $100 million in such holdings. Managers file it up to 45 days after each quarter ends, so this page shows what funds held at the end of each quarter, not what they are doing now: a position may have changed since. Short positions, most derivatives and smaller managers are not included, and a cut can mean a fund lost clients or rebalanced rather than a view on Xenon Pharmaceuticals.

Only managers that filed a holdings report for both quarters are compared (331 here). 8 other holders are left out: first-time or late filers, firms that changed their SEC registration, and filings that withheld positions under confidential treatment, any of which would otherwise look like a new position or a sale. Figures are as reported by each manager in the SEC's quarterly 13F data sets; option positions are excluded.

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