Xilio Therapeutics, Inc.: which funds bought and sold

Institutions that bought and sold Xilio Therapeutics shares in Q2 2026, from the holdings they reported to the SEC on Form 13F for March 31, 2026 and June 30, 2026.

Between March 31, 2026 and June 30, 2026, 14 institutions that filed 13F reports for both quarters added to or opened positions in Xilio Therapeutics, and 11 cut or closed them. Together they added a net 792K shares, +40.3% on what they held at the start of the quarter. Active managers and hedge funds on our list were net buyers of 22K shares (+10.2%); index fund managers were net buyers of 60K shares (+29.4%). 10 opened a new position and 7 sold out entirely.

Bought, Q2 2026 14 institutions, 10 of them new holders Sold, Q2 2026 11 institutions, 7 of them sold out

Net change, all compared +792K shares (+40.3%)

Net change, active managers +22K shares (+10.2%), 5 bought, 3 sold

Buyers versus sellers

institutions compared, 32

14 bought 7 11 sold

Active managers and hedge funds 5 bought · 3 sold · +22K

Index fund managers 3 bought · 1 sold · +60K

Other institutions 6 bought · 7 sold · +710K

Biggest buyers

by change in shares held

Biggest buyers
Institution	Change in shares	Shares June 30, 2026	Value
Orbimed Advisors LLC	+592K New position	592K	$5.7M
Stonepine Capital Management, LLC	+162K +252.2%	226K	$2.2M
Adage Capital Partners Gp, L.L.C. Hedge fund	+112K New position	112K	$1.1M
Vanguard Capital Management LLC Index funds	+55K +44.4%	179K	$1.7M
Citadel Advisors LLC Hedge fund	+26K New position	26K	$248,601
Bridgeway Capital Management, LLC Active manager	+18K New position	18K	$168,072
Renaissance Technologies LLC Hedge fund	+15K +29.4%	64K	$614,586
Two Sigma Investments, LP Hedge fund	+15K New position	15K	$139,332
Prelude Capital Management, LLC	+12K New position	12K	$111,128
Blackrock, Inc. Index funds	+8,757 New position	8,757	$83,892
Geode Capital Management, LLC Index funds	+1,858 +5.0%	39K	$374,174
Steward Partners Investment Advisory, LLC	+714 New position	714	$6,840
Barclays PLC	+115 New position	115	$1,102
Jones Financial Companies LLLP	+29 New position	29	$262

Biggest buyers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
Adage Capital Partners Gp, L.L.C. Hedge fund	+112K New position	112K	$1.1M
Citadel Advisors LLC Hedge fund	+26K New position	26K	$248,601
Bridgeway Capital Management, LLC Active manager	+18K New position	18K	$168,072
Renaissance Technologies LLC Hedge fund	+15K +29.4%	64K	$614,586
Two Sigma Investments, LP Hedge fund	+15K New position	15K	$139,332

Biggest sellers

by change in shares held

Biggest sellers
Institution	Change in shares	Shares June 30, 2026	Value
Caligan Partners LP Hedge fund	−112K Sold out	0	—
Aju Ib Investment Co., Ltd.	−48K Sold out	0	—
FMR LLC Active manager	−37K Sold out	0	—
Ghisallo Capital Management LLC Hedge fund	−14K Sold out	0	—
Vanguard Fiduciary Trust Co Index funds	−5,881 −20.7%	23K	$216,451
UBS Group AG	−4,024 −99.7%	14	$134
Gsa Capital Partners LLP	−3,356 −19.8%	14K	$130,000
Morgan Stanley	−539 −0.9%	57K	$545,619
Jpmorgan Chase & Co	−240 Sold out	0	—
Vanguard Global Advisers, LLC	−210 Sold out	0	—
Royal Bank Of Canada	−91 Sold out	0	—

Biggest sellers, active managers and hedge funds
Institution	Change in shares	Value
Caligan Partners LP Hedge fund	−112K Sold out	—
FMR LLC Active manager	−37K Sold out	—
Ghisallo Capital Management LLC Hedge fund	−14K Sold out	—

New positions

largest by value

Institution	Shares	Value June 30, 2026
Orbimed Advisors LLC	592K	$5.7M
Adage Capital Partners Gp, L.L.C.Hedge fund	112K	$1.1M
Citadel Advisors LLCHedge fund	26K	$248,601
Bridgeway Capital Management, LLCActive manager	18K	$168,072
Two Sigma Investments, LPHedge fund	15K	$139,332
Prelude Capital Management, LLC	12K	$111,128
Blackrock, Inc.Index funds	8,757	$83,892
Steward Partners Investment Advisory, LLC	714	$6,840
Barclays PLC	115	$1,102
Jones Financial Companies LLLP	29	$262

Sold out

largest by value

Institution	Shares	Value March 31, 2026
Caligan Partners LPHedge fund	112K	$942,996
Aju Ib Investment Co., Ltd.	48K	$401,115
FMR LLCActive manager	37K	$307,453
Ghisallo Capital Management LLCHedge fund	14K	$116,058
Jpmorgan Chase & Co	240	$1,976
Vanguard Global Advisers, LLC	210	$1,766
Royal Bank Of Canada	91	$1,000

Who holds the shares

13F holdings at June 30, 2026

Institutions reporting: 25
Ten largest holders: 93.4%
Index fund managers: 9.5%
Active managers and hedge funds: 8.5%

Buying and selling by type of institution, March 31, 2026 to June 30, 2026
Type	Bought	Sold	New	Sold out	Net change in shares	Net %
Active managers and hedge funds	5	3	4	3	+22K	+10.2%
Index fund managers	3	1	1	0	+60K	+29.4%
Other institutions	6	7	5	4	+710K	+45.8%

Active managers and hedge funds: a list we maintain of about 400 well-known stock-picking firms and hedge funds, matched by SEC registration number (CIK) and checked against the filer names each quarter. Index fund managers: the large index houses, such as BlackRock, Vanguard, State Street, Geode and Northern Trust. Every other filer (banks, brokers, wealth managers, pension funds, insurers and firms not on the list) counts as another institution. A firm that files under several SEC registrations appears once for each.

What these filings can and cannot tell you

Form 13F lists the long positions in US-listed shares held by investment managers with more than $100 million in such holdings. Managers file it up to 45 days after each quarter ends, so this page shows what funds held at the end of each quarter, not what they are doing now: a position may have changed since. Short positions, most derivatives and smaller managers are not included, and a cut can mean a fund lost clients or rebalanced rather than a view on Xilio Therapeutics.

Only managers that filed a holdings report for both quarters are compared (32 here). 1 other holder is left out: first-time or late filers, firms that changed their SEC registration, and filings that withheld positions under confidential treatment, any of which would otherwise look like a new position or a sale. Figures are as reported by each manager in the SEC's quarterly 13F data sets; option positions are excluded.

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