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Alkermes plc. vs Madrigal Pharmaceuticals

Alkermes plc. is the larger business, with $1.48bn of revenue in fiscal 2025 against $958m for Madrigal Pharmaceuticals (1.5 times as much). Madrigal Pharmaceuticals grew faster (432.1% against -5.2%). Alkermes plc. kept more of each dollar of sales as profit: a net margin of 16.4% against -30.1%. Alkermes plc. carries less debt relative to equity (0.0% against 80.6%).

Latest fiscal yearAlkermes plc.ALKS, 2025Madrigal PharmaceuticalsMDGL, 2025
Revenue $1.48bn $958m
Revenue growth -5.2% 432.1%
Net income $242m −$288m
Operating margin 17.2% -31.3%
Net margin 16.4% -30.1%
Return on equity 14.7% -42.5%
Free cash flow $480m −$190m
Cash $389m $199m
Total debt $0 $486m
Debt to equity 0.0% 80.6%
Dividend per share — —
Dividend yield — —
Share buybacks — —
Employees 2,050 915
Market value $7.84bn $9.38bn
Price vs our value range Within our value range —
Moat score 63 (Moderate) —
Insider trades, 12 months 0 buys, 33 sales 0 buys, 202 sales

Each figure is from the company's latest annual report and links to the page it comes from. Fiscal years can end on different dates. Market value and the value verdict use the delayed price shown on the stock pages. Not a recommendation.

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Figures from each company's latest annual report filed with the SEC (10-K or 20-F), as reported, with the fiscal year shown. Not investment advice. How we read filings: methodology.