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Alnylam Pharmaceuticals vs Biomarin Pharmaceutical

Alnylam Pharmaceuticals is the larger business, with $3.71bn of revenue in fiscal 2025 against $3.22bn for Biomarin Pharmaceutical (1.2 times as much). Alnylam Pharmaceuticals grew faster (65.2% against 12.9%). Biomarin Pharmaceutical kept more of each dollar of sales as profit: a net margin of 10.8% against 8.4%. Biomarin Pharmaceutical carries less debt relative to equity (9.9% against 127.7%).

Latest fiscal yearAlnylam PharmaceuticalsALNY, 2025Biomarin PharmaceuticalBMRN, 2025
Revenue $3.71bn $3.22bn
Revenue growth 65.2% 12.9%
Net income $314m $349m
Operating margin 13.5% 12.7%
Net margin 8.4% 10.8%
Return on equity 73.3% 5.9%
Free cash flow $465m $725m
Cash $1.66bn $1.31bn
Total debt $1.01bn $600m
Debt to equity 127.7% 9.9%
Dividend per share — —
Dividend yield — —
Share buybacks — —
Employees 2,500 3,221
Market value $21.46bn $10.80bn
Price vs our value range Above our value range Within our value range
Moat score 33 (Weak) 40 (Weak)
Insider trades, 12 months 0 buys, 279 sales 0 buys, 5 sales

Each figure is from the company's latest annual report and links to the page it comes from. Fiscal years can end on different dates. Market value and the value verdict use the delayed price shown on the stock pages. Not a recommendation.

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Figures from each company's latest annual report filed with the SEC (10-K or 20-F), as reported, with the fiscal year shown. Not investment advice. How we read filings: methodology.