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Anaptysbio vs Puma Biotechnology

Anaptysbio and Puma Biotechnology are similar in size: $235m and $228m of revenue in their latest fiscal years. Anaptysbio grew faster (157.0% against -0.9%). Puma Biotechnology kept more of each dollar of sales as profit: a net margin of 13.6% against -5.6%. Anaptysbio carries less debt relative to equity (0.0% against 17.4%).

Latest fiscal yearAnaptysbioANAB, 2025Puma BiotechnologyPBYI, 2025
Revenue $235m $228m
Revenue growth 157.0% -0.9%
Net income −$13.2m $31.1m
Operating margin 96.7% 16.3%
Net margin -5.6% 13.6%
Return on equity -24.5% 28.0%
Free cash flow $19.6m $41.7m
Cash $138m $29.6m
Total debt $0 $22.7m
Debt to equity 0.0% 17.4%
Dividend per share — —
Dividend yield — —
Share buybacks $68.6m —
Employees 104 179
Market value $1.42bn $521m
Price vs our value range — Below our value range
Moat score 13 (Weak) 47 (Moderate)
Insider trades, 12 months 0 buys, 42 sales 0 buys, 17 sales

Each figure is from the company's latest annual report and links to the page it comes from. Fiscal years can end on different dates. Market value and the value verdict use the delayed price shown on the stock pages. Not a recommendation.

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Figures from each company's latest annual report filed with the SEC (10-K or 20-F), as reported, with the fiscal year shown. Not investment advice. How we read filings: methodology.