Denali Therapeutics Inc.: which funds bought and sold

Institutions that bought and sold Denali Therapeutics shares in Q2 2026, from the holdings they reported to the SEC on Form 13F for March 31, 2026 and June 30, 2026.

Between March 31, 2026 and June 30, 2026, 171 institutions that filed 13F reports for both quarters added to or opened positions in Denali Therapeutics, and 96 cut or closed them. Together they added a net 5.6M shares, +3.8% on what they held at the start of the quarter. Active managers and hedge funds on our list were net buyers of 3.5M shares (+6.0%); index fund managers were net buyers of 2.6M shares (+6.7%). 51 opened a new position and 28 sold out entirely.

Bought, Q2 2026 171 institutions, 51 of them new holders Sold, Q2 2026 96 institutions, 28 of them sold out

Net change, all compared +5.6M shares (+3.8%)

Net change, active managers +3.5M shares (+6.0%), 23 bought, 22 sold

Buyers versus sellers

institutions compared, 315

171 bought 48 96 sold

Active managers and hedge funds 23 bought · 22 sold · +3.5M

Index fund managers 10 bought · 2 sold · +2.6M

Other institutions 138 bought · 72 sold · −530K

Biggest buyers

by change in shares held

Biggest buyers
Institution	Change in shares	Shares June 30, 2026	Value
T. Rowe Price Investment Management, Inc. Active manager	+7.7M +89.9%	16.2M	$416M
Nomura Asset Management International Inc.	+2.1M +1828.2%	2.2M	$56.8M
BNP Paribas Asset Management Holding S.A.	+1.1M +357.2%	1.4M	$34.9M
Blackrock, Inc. Index funds	+992K +7.6%	14.0M	$361M
State Street Corp Index funds	+777K +12.4%	7.0M	$181M
Holocene Advisors, LP Hedge fund	+710K +22.2%	3.9M	$100M
Price T Rowe Associates Inc Active manager	+672K +27.3%	3.1M	$80.7M
UBS Group AG	+549K +21.4%	3.1M	$80.3M
Citigroup Inc	+448K +1140.6%	487K	$12.5M
Dafna Capital Management LLC	+421K +132.0%	739K	$19M
Vanguard Portfolio Management LLC Index funds	+357K +5.8%	6.5M	$167M
Exoduspoint Capital Management, LP Hedge fund	+337K New position	337K	$8.7M
Nuveen, LLC	+313K +106.0%	609K	$15.7M
AQR Capital Management LLC Hedge fund	+286K +278.7%	388K	$10M
Geode Capital Management, LLC Index funds	+246K +6.6%	4.0M	$102M
Pictet Asset Management Holding SA	+232K +9.1%	2.8M	$71.9M
Casdin Capital, LLC Hedge fund	+205K +11.1%	2.0M	$52.6M
Foresite Capital Management Vi LLC	+187K +15.4%	1.4M	$35.9M
Dimensional Fund Advisors LP	+168K +6.3%	2.9M	$73.6M
E. Ohman J:Or Asset Management AB	+160K New position	160K	$4.1M

Biggest buyers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
T. Rowe Price Investment Management, Inc. Active manager	+7.7M +89.9%	16.2M	$416M
Holocene Advisors, LP Hedge fund	+710K +22.2%	3.9M	$100M
Price T Rowe Associates Inc Active manager	+672K +27.3%	3.1M	$80.7M
Exoduspoint Capital Management, LP Hedge fund	+337K New position	337K	$8.7M
AQR Capital Management LLC Hedge fund	+286K +278.7%	388K	$10M
Casdin Capital, LLC Hedge fund	+205K +11.1%	2.0M	$52.6M
Artisan Partners Limited Partnership Active manager	+125K +11.3%	1.2M	$31.5M
Pfm Health Sciences, LP Hedge fund	+101K New position	101K	$2.6M
Alliancebernstein L.P. Active manager	+91K +3.2%	3.0M	$57.3M
Capital Research Global Investors Active manager	+51K +2.0%	2.6M	$66M

Biggest sellers

by change in shares held

Biggest sellers
Institution	Change in shares	Shares June 30, 2026	Value
Lynx1 Capital Management LP	−1.9M −99.4%	12K	$299,844
Vestal Point Capital, LP Hedge fund	−1.8M Sold out	0	—
Alyeska Investment Group, L.P. Hedge fund	−1.7M −88.7%	219K	$5.6M
UBS Am, A Distinct Business Unit Of UBS Asset Management Americas LLC	−1.3M −28.7%	3.2M	$81.3M
Defilade Capital Management, L.P.	−968K −71.2%	392K	$10.1M
Stempoint Capital LP	−853K Sold out	0	—
ADAR1 Capital Management, LLC Hedge fund	−842K −45.0%	1.0M	$26.5M
Clearstead Advisors, LLC	−738K −100.0%	62	$1,595
Aberdeen Group PLC	−509K −27.4%	1.3M	$34.6M
Marshall Wace, LLP Hedge fund	−441K −44.5%	550K	$14.1M
Masters Capital Management LLC Hedge fund	−400K −66.7%	200K	$5.1M
Crestline Management, L.P.	−300K −13.6%	1.9M	$49.1M
Braidwell LP Hedge fund	−296K Sold out	0	—
Schroder Investment Management Group Active manager	−286K Sold out	0	—
Goldman Sachs Group Inc	−251K −5.7%	4.2M	$107M
Palo Alto Investors LP	−235K Sold out	0	—
American Century Companies Inc Active manager	−223K −23.9%	713K	$18.3M
Hudson Bay Capital Management LP Hedge fund	−216K −62.5%	130K	$3.3M
Balyasny Asset Management L.P. Hedge fund	−195K Sold out	0	—
Sector Gamma As	−163K Sold out	0	—

Biggest sellers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
Vestal Point Capital, LP Hedge fund	−1.8M Sold out	0	—
Alyeska Investment Group, L.P. Hedge fund	−1.7M −88.7%	219K	$5.6M
ADAR1 Capital Management, LLC Hedge fund	−842K −45.0%	1.0M	$26.5M
Marshall Wace, LLP Hedge fund	−441K −44.5%	550K	$14.1M
Masters Capital Management LLC Hedge fund	−400K −66.7%	200K	$5.1M
Braidwell LP Hedge fund	−296K Sold out	0	—
Schroder Investment Management Group Active manager	−286K Sold out	0	—
American Century Companies Inc Active manager	−223K −23.9%	713K	$18.3M
Hudson Bay Capital Management LP Hedge fund	−216K −62.5%	130K	$3.3M
Balyasny Asset Management L.P. Hedge fund	−195K Sold out	0	—

New positions

largest by value

Institution	Shares	Value June 30, 2026
Exoduspoint Capital Management, LPHedge fund	337K	$8.7M
E. Ohman J:Or Asset Management AB	160K	$4.1M
Odyssean, LLC	125K	$3.2M
Pfm Health Sciences, LPHedge fund	101K	$2.6M
Integral Health Asset Management, LLC	100K	$2.6M
Phocas Financial Corp.	71K	$1.8M
Savvy Advisors, Inc.	45K	$1.2M
Tudor Investment Corp Et AlHedge fund	41K	$1.1M
Jain Global LLCHedge fund	38K	$988,548
Yorktown Management & Research Co Inc	32K	$825,612

Sold out

largest by value

Institution	Shares	Value March 31, 2026
Vestal Point Capital, LPHedge fund	1.8M	$34M
Stempoint Capital LP	853K	$16.4M
Braidwell LPHedge fund	296K	$5.7M
Schroder Investment Management GroupActive manager	286K	$5.2M
Palo Alto Investors LP	235K	$4.5M
Balyasny Asset Management L.P.Hedge fund	195K	$3.7M
Sector Gamma As	163K	$3.1M
Y-Intercept (Hong Kong) Ltd	78K	$1.5M
Polen Capital Management LLCActive manager	65K	$1.3M
Virtu Financial LLC	43K	$833,000

Who holds the shares

13F holdings at June 30, 2026

Institutions reporting: 292
Ten largest holders: 52.3%
Index fund managers: 26.7%
Active managers and hedge funds: 39.2%

Buying and selling by type of institution, March 31, 2026 to June 30, 2026
Type	Bought	Sold	New	Sold out	Net change in shares	Net %
Active managers and hedge funds	23	22	8	6	+3.5M	+6.0%
Index fund managers	10	2	0	0	+2.6M	+6.7%
Other institutions	138	72	43	22	−530K	−1.0%

Active managers and hedge funds: a list we maintain of about 400 well-known stock-picking firms and hedge funds, matched by SEC registration number (CIK) and checked against the filer names each quarter. Index fund managers: the large index houses, such as BlackRock, Vanguard, State Street, Geode and Northern Trust. Every other filer (banks, brokers, wealth managers, pension funds, insurers and firms not on the list) counts as another institution. A firm that files under several SEC registrations appears once for each.

What these filings can and cannot tell you

Form 13F lists the long positions in US-listed shares held by investment managers with more than $100 million in such holdings. Managers file it up to 45 days after each quarter ends, so this page shows what funds held at the end of each quarter, not what they are doing now: a position may have changed since. Short positions, most derivatives and smaller managers are not included, and a cut can mean a fund lost clients or rebalanced rather than a view on Denali Therapeutics.

Only managers that filed a holdings report for both quarters are compared (315 here). 9 other holders are left out: first-time or late filers, firms that changed their SEC registration, and filings that withheld positions under confidential treatment, any of which would otherwise look like a new position or a sale. Figures are as reported by each manager in the SEC's quarterly 13F data sets; option positions are excluded.

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