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Denali Therapeutics Inc. (DNLI) stock

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NASDAQ: DNLI Nasdaq Biotechnology Next results ~November 3, 2026

Denali Therapeutics Inc. is a US-listed company in the biotechnology industry. Its financial year ends in December.

Who’s trading

What company insiders, investment funds and members of Congress have been doing with the stock, from their own filings.

  • Insiders0 buying, 4 selling0 purchases and 7 sales by directors and officers, last 12 monthsInsider trades
  • Funds171 adding, 96 cuttingOf 45 active managers that changed their stake, 23 added; quarter to June 30, 2026Fund buyers and sellers

The Fundamentalytics view

Next results ~November 3, 2026 (estimated)

Current signal Results well short of expectations: Reported earnings per share missed the analysts' consensus estimate by 46% in the quarter to 2026-06-30.

Assembled from SEC-filed figures — the full workings are on this page and in our methodology. Observations, not recommendations.

Highlights

How we pick these

Strengths

Nothing in Denali Therapeutics Inc.'s latest figures clears our strength thresholds.

Things to watch

  • Results due soon. Results are expected around 5 November; the share price can move sharply on the day.
  • Volatile shares. Over the past year the shares showed annualised volatility of 55% and a beta of 1.5 against the S&P 500.
  • Heavily shorted. 10.2% of the shares available to trade are sold short (7.8 days of average volume to cover).

Latest results

Earnings per share
-$0.68 against an average estimate of -$0.47: missed by 45.5%
Share reaction
+1.7% in the first session after the results on August 6, 2026, against +0.5% for the S&P 500
Next report
November 3, 2026; average EPS estimate -$0.37

Denali Therapeutics' figures from its SEC filings and results release; estimates are the analysts' average. Not a recommendation.

Price chart

  • 1 day-0.4%
  • 1 week+1.1%
  • 1 month-5.7%
  • This year+14.2%
  • 1 year+15.8%
  • 5 years-64.5%
  • S&P 500 this year+11.2%

Closing prices to 2026-11-02. Price change only, dividends excluded.

Loading chart…

Third-party market data · may be delayed

At a glance

Trailing twelve months, from SEC filings

Earnings

Last results
August 6, 2026
Next results (est.)
November 5, 2026

News & updates

Updated October 31, 2026

Company announcements, filed results and changes that matter to shareholders.

  1. Results
  2. Deal

Refreshed hourly when new source data is available. Summaries are checked against company releases and SEC filings. Company announcement headlines are labelled when a checked summary is unavailable.

Valuation

Denali Therapeutics Inc. valuation models and calculator

No model value for Denali Therapeutics Inc. at the moment. Current status: limited reported history: available models are shown without a Buy/Hold/Sell rating. Available reported financials are shown below.

Fundamentalytics rating

model v1.6 · 2026-11-03

Not rated: limited reported history: available models are shown without a Buy/Hold/Sell rating.

Moat

Not assessed: fewer than five years of comparable figures in the filings. AI disruption exposure for this industry: Medium.

A rules-based reading of reported figures, not a forecast and not investment advice. How the score is built: methodology.

Forecasts and guidance

Next results: November 3, 2026, after the close. Analysts expect revenue of $23m and EPS of −$0.37 (range −$0.88 to $0.38) for the quarter.

Analysts' consensus

Fiscal yearEPSGrowthRevenueGrowth
Current −$2.23 +25% $51m 0%
Next −$2.42 −9% $131m +158%

How the EPS forecast has moved

The consensus EPS forecast for the current fiscal year is −6.0% on 90 days ago. In the last 30 days, 0 analysts raised Denali Therapeutics Inc.'s forecast and 1 cut it.

Consensus EPS forecast Denali Therapeutics Inc., last 90 days
−$3.00 −$2.00 −$1.00 $0.00 90 days ago 60 days ago 30 days ago 7 days ago Now Current fiscal year, 90 days ago: −$2.37 Current fiscal year, 60 days ago: −$2.35 Current fiscal year, 30 days ago: −$2.22 Current fiscal year, 7 days ago: −$2.23 Current fiscal year, Now: −$2.23 −$2.23 Next fiscal year, 90 days ago: −$2.53 Next fiscal year, 60 days ago: −$2.43 Next fiscal year, 30 days ago: −$2.42 Next fiscal year, 7 days ago: −$2.42 Next fiscal year, Now: −$2.42 −$2.42

Average of analysts' published estimates (third-party data).

View chart data
Period Current fiscal yearNext fiscal year
90 days ago −$2.37−$2.53
60 days ago −$2.35−$2.43
30 days ago −$2.22−$2.42
7 days ago −$2.23−$2.42
Now −$2.23−$2.42

Earnings against estimates

Quarter toEstimateActualSurprise
Jun 2026 −$0.47 −$0.68 −45.5%
Mar 2026 −$0.71 −$0.69 +2.3%
Dec 2025 −$0.75 −$0.73 +2.5%
Sept 2025 −$0.76 −$0.74 +2.4%

Adjusted EPS as companies report it, against the average analyst estimate.

Analyst recommendations

20 analysts, Oct 2026
Buy1995%
Hold15%
Sell00%

Monthly trend

  1. Oct 202621720
  2. Sep 202621720
  3. Aug 202621720
  4. Jul 202621720

Counts of recommendations published by analysts covering Denali Therapeutics Inc., by month. Source: Aggregated broker recommendations (third-party data). Aggregated counts only: we do not reproduce any firm's recommendation or price target, and these are not Fundamentalytics ratings.

Positioning

Short interest
10.2%
of tradable shares
Days to cover
7.76
at average volume
Short interest, 1 month
−10%
to October 15, 2026
Held by institutions
—
of shares
Held by insiders
4.6%
of shares
Employees
503
full time

Consensus figures average analysts' published estimates (third-party data); guidance is the company's own. Neither is our forecast. Short interest is reported twice a month and lags. Market data may be delayed.

This section is general information, not investment advice or a personal recommendation, and it does not take account of your objectives or circumstances. Forecasts and guidance are estimates, not promises: companies miss their own guidance and analysts' figures are often revised. Prices can fall as well as rise, and you can lose money. See our disclaimer.

Share-price performance

Market data may be delayed

Return and risk by year

Calendar year 202120222023202420252026 to date
Return
DNLI−47%−38%−23%−5%−19%+14%
Industry peers (median)−35%−57%−17%−29%−5%−27%
S&P 500+29%−18%+26%+25%+18%+11%
Months that ended higher
DNLI42%42%33%58%50%36%
S&P 50075%42%67%75%75%46%
Largest fall from a high during the year
DNLI−49%−56%−51%−36%−51%−35%
S&P 500−5%−25%−10%−8%−19%−9%

Worst fall since December 8, 2017: 88% from December 22, 2020 to April 8, 2025. Getting back needed a 716% gain, and the shares have not yet recovered.

Price behaviour

52-week range
$14.41 – $27.21
From 52-week high
−30.7%
vs 50-day average
−8.1%
vs 200-day average
−11.2%
Volatility (1 year)
55%
Beta vs S&P 500
1.54

Volatility is the annualised standard deviation of daily returns. Beta 1.5 means the shares typically moved 1.5% for each 1% move in the S&P 500 over the past year. Prices to November 2, 2026.

Share price after results

Next day
5 up, 7 down
typical move ±7.5%
After a week
6 up, 6 down
typical move ±10.3%
After a month
5 up, 7 down
typical move ±14.1%
Results releasedNext dayS&P 500 next day5 days21 days
August 6, 2026 +1.7% +0.5% +1.6% −8.8%
May 7, 2026 −3.9% +0.5% −5.0% −4.3%
February 26, 2026 −5.0% −1.0% −11.6% −18.5%
November 6, 2025 +0.9% −1.0% +15.2% +32.2%
August 11, 2025 −5.3% +0.9% +6.2% +4.9%
May 6, 2025 −10.4% −0.4% −10.8% −11.1%
February 27, 2025 −12.3% −0.1% −13.9% −21.8%
November 6, 2024 +7.1% +3.3% +7.2% −10.0%
August 1, 2024 −10.3% −3.3% −8.6% +0.3%
May 7, 2024 +10.3% +0.1% +15.2% +24.3%
February 27, 2024 +19.7% +0.1% +21.1% +23.0%
November 7, 2023 −2.7% +0.4% −7.8% −9.7%

From the close before the release date to the close 1, 5 and 21 trading days after it, so releases before the open and after the close are both captured. Past moves don't predict future ones.

Fundamentals

Data: SEC EDGAR XBRL company facts (as filed in 10-K/10-Q); forms . Generated November 3, 2026. Definitions in our methodology.

Who owns it

Funds buying and selling
Reported value
$4B
Institutions reporting
292
Shares held vs prior quarter
▲ 5.7%
Positions opened / closed
51 / 28

Top buyers and sellers, Q2 2026: 171 institutions bought and 96 sold ; the biggest buyer was T. Rowe Price Investment Management, Inc (+7.7M shares) and the biggest seller Lynx1 Capital Management LP (−1.9M). See which funds bought and sold →

Largest reported holders, June 30, 2026
Manager Value Shares Share of 13F value Shares QoQ
T. Rowe Price Investment Management, Inc. $416M 16.2M 10.4% ▲ 89.9%
Blackrock, Inc. $361M 14.0M 9.0% ▲ 7.6%
Baillie Gifford & Co $308M 12.0M 7.7% ▼ 0.9%
State Street Corp $181M 7.0M 4.5% ▲ 12.4%
Temasek Holdings (Private) Ltd $180M 7.0M 4.5% 0.0%
Vanguard Portfolio Management LLC $167M 6.5M 4.2% ▲ 5.8%
Vanguard Capital Management LLC $161M 6.3M 4.0% ▲ 2.1%
FMR LLC $117M 4.5M 2.9% ▼ 0.9%
Goldman Sachs Group Inc $107M 4.2M 2.7% ▼ 5.7%
Geode Capital Management, LLC $102M 4.0M 2.6% ▲ 6.6%
Holocene Advisors, LP $100M 3.9M 2.5% ▲ 22.2%
Baker Bros. Advisors LP $96M 3.7M 2.4% ▲ 0.1%

From Form 13F filings with the SEC ( quarterly data sets), as reported by each manager for June 30, 2026 and filed up to 45 days later. 13F reports cover long US-listed positions of managers above $100M only, so this is not Denali Therapeutics Inc.'s complete shareholder register. Values are as reported by the filers .

Insider trading activity

Full insider history and chart
Insider purchases History → $0 0 trades by 0 insiders, last 12 months Insider sales History → $1.3M 7 trades by 4 insiders · 25% under pre-set plans
Net ▼ $1.3M net selling
Insider Date Trade Shares Price Value
Chin Peter Scott Chief Medical Officer September 4, 2026 Sell 1,654 $22.29 $36,868
Thornberry Nancy Director September 2, 2026 Sell pre-set plan 615 $23.74 $14,600
Thornberry Nancy Director September 2, 2026 Sell pre-set plan 10,824 $22.85 $247,328
Schuth Alexander O. COFO and Secretary September 1, 2026 Sell pre-set plan 2,768 $23.44 $64,882
Schuth Alexander O. COFO and Secretary August 11, 2026 Sell 2,857 $25.07 $71,625
Schuth Alexander O. COFO and Secretary January 6, 2026 Sell 17,218 $16.50 $284,097
Watts Ryan J. President and CEO January 6, 2026 Sell 35,198 $16.50 $580,767

From insiders' Form 4 filings with the SEC. Excludes awards, option exercises and shares withheld for tax. "Pre-set plan" means the filing marks the trade as made under a Rule 10b5-1 plan. See every insider trade since five years ago, on a price chart.

Earnings dates and SEC filings

Results announcements

Next expected around November 5, 2026 estimated from the company's past filing pattern, not announced

  • August 6, 2026
  • May 7, 2026
  • February 26, 2026
  • November 6, 2025
  • August 11, 2025
  • May 6, 2025

Recent SEC filings

Data status

When each part of this page on Denali Therapeutics Inc. was last updated.

DataLast updatedSource
Share priceExchange closing prices
News and updatesCompany releases and SEC 8-K filings
Analyst estimatesAggregated analyst estimates
Valuation and scoresOur models, from the filed figures

How we build and check these figures: methodology and data sources.

Denali Therapeutics Inc. in brief

What does Denali Therapeutics Inc. do?
Denali Therapeutics Inc. is a US-listed company in the biotechnology industry. Its financial year ends in December.
What is Denali Therapeutics Inc.'s stock ticker?
Denali Therapeutics Inc. trades under the ticker DNLI on Nasdaq. This page brings together its financial statements, valuation models, ownership and recent company updates.
Who are Denali Therapeutics Inc.'s largest institutional shareholders?
By value reported in 13F filings for June 30, 2026, the largest reported holders are T. Rowe Price Investment Management, Inc., Blackrock, Inc. and Baillie Gifford & Co. 13F reports cover long US-listed positions of managers above $100M, filed up to 45 days after quarter end.
Are insiders buying or selling Denali Therapeutics Inc. stock?
Over the last 12 months, Denali Therapeutics Inc.'s directors and officers reported 0 open-market purchases and 7 sales on Form 4. The insider trading page charts every trade.
When is Denali Therapeutics Inc.'s next earnings date?
Around November 3, 2026, estimated from the spacing of its past results announcements (8-K filings). That is an estimate, not a confirmed date — Denali Therapeutics Inc. announces its own schedule.