Taysha Gene Therapies, Inc.: which funds bought and sold

Institutions that bought and sold Taysha Gene Therapies shares in Q2 2026, from the holdings they reported to the SEC on Form 13F for March 31, 2026 and June 30, 2026.

Between March 31, 2026 and June 30, 2026, 136 institutions that filed 13F reports for both quarters added to or opened positions in Taysha Gene Therapies, and 62 cut or closed them. Together they added a net 29.4M shares, +11.1% on what they held at the start of the quarter. Active managers and hedge funds on our list were net buyers of 4.8M shares (+3.9%); index fund managers were net buyers of 8.0M shares (+15.1%). 38 opened a new position and 22 sold out entirely.

Bought, Q2 2026 136 institutions, 38 of them new holders Sold, Q2 2026 62 institutions, 22 of them sold out

Net change, all compared +29.4M shares (+11.1%)

Net change, active managers +4.8M shares (+3.9%), 26 bought, 14 sold

Buyers versus sellers

institutions compared, 224

136 bought 26 62 sold

Active managers and hedge funds 26 bought · 14 sold · +4.8M

Index fund managers 10 bought · 2 sold · +8.0M

Other institutions 100 bought · 46 sold · +16.6M

Biggest buyers

by change in shares held

Biggest buyers
Institution	Change in shares	Shares June 30, 2026	Value
Mpm Bioimpact LLC	+4.5M New position	4.5M	$30.6M
Wellington Management Group LLP Active manager	+3.3M +534.7%	4.0M	$27.1M
Pictet Asset Management Holding SA	+2.8M +14242.6%	2.8M	$18.9M
Blackrock, Inc. Index funds	+2.3M +12.7%	20.7M	$141M
Vanguard Capital Management LLC Index funds	+2.2M +22.0%	12.5M	$85M
Avoro Capital Advisors LLC Hedge fund	+2.2M +10.1%	23.9M	$163M
Orbimed Advisors LLC	+2.0M New position	2.0M	$13.6M
Heights Capital Management, Inc	+1.5M New position	1.5M	$10.2M
Vestal Point Capital, LP Hedge fund	+1.4M +7.9%	19.4M	$132M
Aberdeen Group PLC	+1.3M +127.9%	2.3M	$15.8M
Citadel Advisors LLC Hedge fund	+1.1M +273.4%	1.5M	$10.5M
Vanguard Portfolio Management LLC Index funds	+1.1M +55.3%	3.1M	$21.4M
Geode Capital Management, LLC Index funds	+1.0M +18.6%	6.6M	$44.7M
Siren, L.L.C.	+1.0M +11.5%	9.8M	$67.1M
Healthcare Of Ontario Pension Plan Trust Fund	+1.0M +34.8%	3.9M	$26.5M
Seven Fleet Capital Management LP	+879K +140.4%	1.5M	$9.9M
Octagon Capital Advisors LP	+833K +9.4%	9.7M	$66M
First Trust Advisors LP	+791K New position	791K	$5.4M
Affinity Asset Advisors, LLC	+750K +75.0%	1.8M	$11.9M
Affinity Wealth Management LLC	+577K New position	577K	$3.9M

Biggest buyers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
Wellington Management Group LLP Active manager	+3.3M +534.7%	4.0M	$27.1M
Avoro Capital Advisors LLC Hedge fund	+2.2M +10.1%	23.9M	$163M
Vestal Point Capital, LP Hedge fund	+1.4M +7.9%	19.4M	$132M
Citadel Advisors LLC Hedge fund	+1.1M +273.4%	1.5M	$10.5M
Adage Capital Partners Gp, L.L.C. Hedge fund	+553K New position	553K	$3.8M
Holocene Advisors, LP Hedge fund	+510K New position	510K	$3.5M
Ghisallo Capital Management LLC Hedge fund	+505K New position	505K	$3.4M
Burkehill Global Management, LP Hedge fund	+500K New position	500K	$3.4M
Panagora Asset Management Inc Active manager	+408K +224.1%	590K	$4M
Trexquant Investment LP Hedge fund	+380K New position	380K	$2.6M

Biggest sellers

by change in shares held

Biggest sellers
Institution	Change in shares	Shares June 30, 2026	Value
Deerfield Management Company, L.P. Hedge fund	−2.7M Sold out	0	—
SG Americas Securities, LLC	−2.0M −90.7%	202K	$1.4M
Morgan Stanley	−1.5M −8.2%	16.5M	$112M
Barclays PLC	−1.2M −42.0%	1.6M	$11.1M
Millennium Management LLC Hedge fund	−1.2M −35.2%	2.1M	$14.5M
FMR LLC Active manager	−985K −6.9%	13.3M	$90.8M
Polar Capital Holdings PLC Active manager	−537K −9.5%	5.1M	$34.8M
Two Sigma Investments, LP Hedge fund	−507K −68.4%	235K	$1.6M
Point72 Asset Management, L.P. Hedge fund	−462K Sold out	0	—
Renaissance Technologies LLC Hedge fund	−413K Sold out	0	—
Bank Of America Corp	−304K −18.1%	1.4M	$9.3M
Superstring Capital Management LP	−258K Sold out	0	—
Jefferies Financial Group Inc.	−150K −31.4%	329K	$2.2M
Rafferty Asset Management, LLC Index funds	−145K −48.4%	155K	$1.1M
Tudor Investment Corp Et Al Hedge fund	−144K Sold out	0	—
RTW Investments, LP Hedge fund	−120K −0.9%	13.6M	$92.3M
Invesco Ltd.	−104K −28.2%	264K	$1.8M
Militia Capital Management LLC	−93K −66.7%	47K	$316,665
Susquehanna International Group, LLP	−89K −76.6%	27K	$184,987
Voya Investment Management LLC	−87K −16.9%	425K	$2.9M

Biggest sellers, active managers and hedge funds
Institution	Change in shares	Shares June 30, 2026	Value
Deerfield Management Company, L.P. Hedge fund	−2.7M Sold out	0	—
Millennium Management LLC Hedge fund	−1.2M −35.2%	2.1M	$14.5M
FMR LLC Active manager	−985K −6.9%	13.3M	$90.8M
Polar Capital Holdings PLC Active manager	−537K −9.5%	5.1M	$34.8M
Two Sigma Investments, LP Hedge fund	−507K −68.4%	235K	$1.6M
Point72 Asset Management, L.P. Hedge fund	−462K Sold out	0	—
Renaissance Technologies LLC Hedge fund	−413K Sold out	0	—
Tudor Investment Corp Et Al Hedge fund	−144K Sold out	0	—
RTW Investments, LP Hedge fund	−120K −0.9%	13.6M	$92.3M
AQR Capital Management LLC Hedge fund	−49K −27.4%	129K	$876,883

New positions

largest by value

Institution	Shares	Value June 30, 2026
Mpm Bioimpact LLC	4.5M	$30.6M
Orbimed Advisors LLC	2.0M	$13.6M
Heights Capital Management, Inc	1.5M	$10.2M
First Trust Advisors LP	791K	$5.4M
Affinity Wealth Management LLC	577K	$3.9M
Adage Capital Partners Gp, L.L.C.Hedge fund	553K	$3.8M
Diadema Partners LP	523K	$3.6M
Holocene Advisors, LPHedge fund	510K	$3.5M
Ghisallo Capital Management LLCHedge fund	505K	$3.4M
Burkehill Global Management, LPHedge fund	500K	$3.4M

Sold out

largest by value

Institution	Shares	Value March 31, 2026
Deerfield Management Company, L.P.Hedge fund	2.7M	$12.2M
Point72 Asset Management, L.P.Hedge fund	462K	$2.1M
Renaissance Technologies LLCHedge fund	413K	$1.8M
Superstring Capital Management LP	258K	$1.2M
Tudor Investment Corp Et AlHedge fund	144K	$641,780
Varcov Co.	59K	$261,544
Abacus Wealth Partners, LLC	58K	$260,337
Legato Capital Management LLC	22K	$97,366
Scientech Research LLC	21K	$94,049
Catalyst Funds Management Pty Ltd	15K	$67,497

Who holds the shares

13F holdings at June 30, 2026

Institutions reporting: 206
Ten largest holders: 59.4%
Index fund managers: 20.5%
Active managers and hedge funds: 43.6%

Buying and selling by type of institution, March 31, 2026 to June 30, 2026
Type	Bought	Sold	New	Sold out	Net change in shares	Net %
Active managers and hedge funds	26	14	7	6	+4.8M	+3.9%
Index fund managers	10	2	0	0	+8.0M	+15.1%
Other institutions	100	46	31	16	+16.6M	+18.7%

Active managers and hedge funds: a list we maintain of about 400 well-known stock-picking firms and hedge funds, matched by SEC registration number (CIK) and checked against the filer names each quarter. Index fund managers: the large index houses, such as BlackRock, Vanguard, State Street, Geode and Northern Trust. Every other filer (banks, brokers, wealth managers, pension funds, insurers and firms not on the list) counts as another institution. A firm that files under several SEC registrations appears once for each.

What these filings can and cannot tell you

Form 13F lists the long positions in US-listed shares held by investment managers with more than $100 million in such holdings. Managers file it up to 45 days after each quarter ends, so this page shows what funds held at the end of each quarter, not what they are doing now: a position may have changed since. Short positions, most derivatives and smaller managers are not included, and a cut can mean a fund lost clients or rebalanced rather than a view on Taysha Gene Therapies.

Only managers that filed a holdings report for both quarters are compared (224 here). 6 other holders are left out: first-time or late filers, firms that changed their SEC registration, and filings that withheld positions under confidential treatment, any of which would otherwise look like a new position or a sale. Figures are as reported by each manager in the SEC's quarterly 13F data sets; option positions are excluded.

← Back to Taysha Gene Therapies, Inc. · Insiders · Politicians