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Ardelyx vs Krystal Biotech

Ardelyx and Krystal Biotech are similar in size: $407m and $389m of revenue in their latest fiscal years. Krystal Biotech grew faster (33.9% against 22.1%). Krystal Biotech kept more of each dollar of sales as profit: a net margin of 52.6% against -15.1%. Krystal Biotech carries less debt relative to equity (0.0% against 121.5%).

Latest fiscal yearArdelyxARDX, 2025Krystal BiotechKRYS, 2025
Revenue $407m $389m
Revenue growth 22.1% 33.9%
Net income −$61.6m $205m
Operating margin -10.1% 41.5%
Net margin -15.1% 52.6%
Return on equity -36.2% 18.9%
Free cash flow −$44.0m $189m
Cash $68.0m $496m
Total debt $203m $0
Debt to equity 121.5% 0.0%
Dividend per share — —
Dividend yield — —
Share buybacks — —
Employees 489 —
Market value $755m $9.00bn
Price vs our value range — Within our value range
Moat score 24 (Weak) —
Insider trades, 12 months 1 buys, 77 sales 0 buys, 142 sales

Each figure is from the company's latest annual report and links to the page it comes from. Fiscal years can end on different dates. Market value and the value verdict use the delayed price shown on the stock pages. Not a recommendation.

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Figures from each company's latest annual report filed with the SEC (10-K or 20-F), as reported, with the fiscal year shown. Not investment advice. How we read filings: methodology.