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Kymera Therapeutics vs Septerna

Septerna is the larger business, with $46.0m of revenue in fiscal 2025 against $39.2m for Kymera Therapeutics (1.2 times as much). Septerna grew faster (4174.5% against -16.7%). Septerna kept more of each dollar of sales as profit: a net margin of -106.4% against -794.0%. Kymera Therapeutics carries less debt relative to equity (0.0% against 0.0%).

Latest fiscal yearKymera TherapeuticsKYMR, 2025SepternaSEPN, 2025
Revenue $39.2m $46.0m
Revenue growth -16.7% 4174.5%
Net income −$311m −$48.9m
Operating margin -891.1% -148.6%
Net margin -794.0% -106.4%
Return on equity -25.8% -12.2%
Free cash flow −$234m $110m
Cash $357m $121m
Total debt $0 $0
Debt to equity 0.0% 0.0%
Dividend per share — —
Dividend yield — —
Share buybacks — —
Employees 238 130
Market value $10.94bn $1.98bn
Price vs our value range — Above our value range
Moat score 14 (Weak) —
Insider trades, 12 months 2 buys, 274 sales 0 buys, 28 sales

Each figure is from the company's latest annual report and links to the page it comes from. Fiscal years can end on different dates. Market value and the value verdict use the delayed price shown on the stock pages. Not a recommendation.

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Figures from each company's latest annual report filed with the SEC (10-K or 20-F), as reported, with the fiscal year shown. Not investment advice. How we read filings: methodology.