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Madrigal Pharmaceuticals vs PTC Therapeutics

PTC Therapeutics is the larger business, with $1.73bn of revenue in fiscal 2025 against $958m for Madrigal Pharmaceuticals (1.8 times as much). Madrigal Pharmaceuticals grew faster (432.1% against 114.5%). PTC Therapeutics kept more of each dollar of sales as profit: a net margin of 39.4% against -30.1%.

Latest fiscal yearMadrigal PharmaceuticalsMDGL, 2025PTC TherapeuticsPTCT, 2025
Revenue $958m $1.73bn
Revenue growth 432.1% 114.5%
Net income −$288m $683m
Operating margin -31.3% 50.1%
Net margin -30.1% 39.4%
Return on equity -42.5% —
Free cash flow −$190m $702m
Cash $199m $985m
Total debt $486m $573m
Debt to equity 80.6% —
Dividend per share — —
Dividend yield — —
Share buybacks — —
Employees 915 —
Market value $9.38bn $5.66bn
Price vs our value range — Above our value range
Moat score — 11 (Weak)
Insider trades, 12 months 0 buys, 202 sales 0 buys, 203 sales

Each figure is from the company's latest annual report and links to the page it comes from. Fiscal years can end on different dates. Market value and the value verdict use the delayed price shown on the stock pages. Not a recommendation.

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Figures from each company's latest annual report filed with the SEC (10-K or 20-F), as reported, with the fiscal year shown. Not investment advice. How we read filings: methodology.