Silence Therapeutics plc entered a material agreement; made a public disclosure
SEC 8-KRead source ↗
Silence Therapeutics plc is a US-listed company in the biotechnology industry. Its financial year ends in December.
Stock price today
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Third-party market data · may be delayed
Model estimate per share
Not valued: the figures our models need are missing or failed our data-quality checks.
Price vs value
No model value: limited reported history: available models are shown without a Buy/Hold/Sell rating. How we value companies.
Silence Therapeutics plc valuation: adjust assumptions and compare models →
Who’s trading
What company insiders, investment funds and members of Congress have been doing with the stock, from their own filings.
- Funds41 adding, 20 cuttingOf 19 active managers that changed their stake, 15 added; quarter to June 30, 2026Fund buyers and sellers
The Fundamentalytics view
Current signal Results well short of expectations: Reported earnings per share missed the analysts' consensus estimate by 145% in the quarter to 2026-06-30.
Assembled from SEC-filed figures — the full workings are on this page and in our methodology. Observations, not recommendations.
Highlights
How we pick theseStrengths
Nothing in Silence Therapeutics plc's latest figures clears our strength thresholds.
Things to watch
- Results due soon. Results are expected around 5 November; the share price can move sharply on the day.
- Volatile shares. Over the past year the shares showed annualised volatility of 150% and a beta of 1.7 against the S&P 500.
- Short interest rising. Shares sold short rose 34% in a month to 5.8% of tradable shares.
- Missing expectations. Earnings per share fell short of the consensus estimate in 2 of the last four quarters.
Latest results
- Earnings per share
- -$0.27 against an average estimate of -$0.11: missed by 145.4%
- Share reaction
- +23.2% in the first session after the results on August 10, 2026, against -0.3% for the S&P 500
- Next report
- November 5, 2026; average EPS estimate -$0.09
Price chart
- 1 day+0.1%
- 1 week-0.1%
- 1 month+85.7%
- This year+225.0%
- 1 year+176.0%
- 5 years-8.2%
- S&P 500 this year+11.2%
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Third-party market data · may be delayed
At a glance
Earnings
- Last results
- August 10, 2026
- Next results (est.)
- November 5, 2026
News & updates
Company announcements, filed results and changes that matter to shareholders.
- Agreement
- Agreement
Silence Therapeutics plc entered a material agreement; disclosed a material event
SEC 8-KRead source ↗ - Announcement
Silence Therapeutics plc made a public disclosure; disclosed a material event
SEC 8-KRead source ↗ - Results
Silence Therapeutics plc reported results
SEC 8-KRead source ↗
Valuation models
We value Silence Therapeutics plc as an operating company, with every model that fits that kind of business. Cost of equity 9.5%: the 10-year Treasury yield (4.9%) plus a beta of 1.01 times a 4.5% equity risk premium.
| Model | Value per share | In the combined value? |
|---|---|---|
| Price-to-earnings vs peers Earnings per share times peers' typical (harmonic-mean) price-to-earnings. | — | Does not apply: no twelve-month earnings or share count in the filings yet |
| Residual income Book value plus the present value of returns above the cost of equity, fading over ten years. | — | Does not apply: no twelve-month earnings or share count in the filings yet |
| Justified price-to-book Book value times (return on equity - growth) / (cost of equity - growth): steady-state returns. | — | Does not apply: no twelve-month earnings or share count in the filings yet |
| Revenue-to-maturity model Revenue grown to maturity with the cash margin moving to the industry's; for companies not yet profitable. | — | Does not apply: revenue and margins don't support a positive value |
| Price-to-sales vs peers Sales per share times peers' typical price-to-sales; used only when earnings are negative. | — | Does not apply: no twelve-month earnings or share count in the filings yet |
| Combined value Weighted average of the models that apply: the primary model (price-to-earnings vs peers) counts double. Models more than 5x or less than 0.2x the share price, or more than 3x away from the other models' median, are left out. | — | No model applies: the filings don’t yet support a value. |
Different models fail in different ways, so where several apply we average them rather than trust one. Peer-based models compare Silence Therapeutics plc with Biotechnology in our coverage, using third-party market data. Model values are estimates under stated assumptions, updated as new filings arrive; not price targets or investment advice. How each model works.
Moat
Not assessed: fewer than five years of comparable figures in the filings. AI disruption exposure for this industry: Medium.
Forecasts and guidance
Next results: November 5, 2026, before the open. Analysts expect revenue of $20830 and EPS of −$0.09 (range −$0.09 to −$0.09) for the quarter.
Analysts' consensus
| Fiscal year | EPS | Growth | Revenue | Growth |
|---|---|---|---|---|
| Current | −$0.36 | +80% | $328760 | −21% |
| Next | −$0.38 | −4% | $760450 | +131% |
How the EPS forecast has moved
The consensus EPS forecast for the current fiscal year is −8.8% on 90 days ago. In the last 30 days, 1 analyst raised Silence Therapeutics plc's forecast and 0 cut it.
Average of analysts' published estimates (third-party data).
View chart data
| Period | Current fiscal year | Next fiscal year |
|---|---|---|
| 90 days ago | −$0.40 | −$0.39 |
| 60 days ago | −$0.72 | −$0.77 |
| 30 days ago | −$0.36 | −$0.38 |
| 7 days ago | −$0.36 | −$0.38 |
| Now | −$0.36 | −$0.38 |
Earnings against estimates
| Quarter to | Estimate | Actual | Surprise |
|---|---|---|---|
| Jun 2026 | −$0.11 | −$0.27 | −145.4% |
| Mar 2026 | −$0.09 | −$0.33 | −266.7% |
| Dec 2025 | −$0.49 | −$0.27 | +44.9% |
| Sept 2025 | −$0.21 | −$0.15 | +27.4% |
Adjusted EPS as companies report it, against the average analyst estimate.
Positioning
- Short interest
- 5.8% of tradable shares
- Days to cover
- 2.7 at average volume
- Short interest, 1 month
- +34% to October 15, 2026
- Held by institutions
- 48% of shares
- Held by insiders
- 7.7% of shares
- Employees
- 88 full time
Share-price performance
Market data may be delayedReturn and risk by year
| Calendar year | 2021 | 2022 | 2023 | 2024 | 2025 | 2026 to date |
|---|---|---|---|---|---|---|
| Return | ||||||
| SLN | +9% | −36% | +14% | −60% | −12% | +225% |
| Industry peers (median) | −36% | −57% | −18% | −28% | −5% | −27% |
| S&P 500 | +29% | −18% | +26% | +25% | +18% | +11% |
| Months that ended higher | ||||||
| SLN | 58% | 33% | 58% | 33% | 42% | 55% |
| S&P 500 | 75% | 42% | 67% | 75% | 75% | 46% |
| Largest fall from a high during the year | ||||||
| SLN | −27% | −67% | −71% | −76% | −71% | −44% |
| S&P 500 | −5% | −25% | −10% | −8% | −19% | −9% |
Worst fall since September 8, 2020: 92% from June 28, 2021 to April 9, 2025. Getting back needed a 1201% gain, and the shares have not yet recovered.
Price behaviour
- 52-week range
- $4.30 – $19.80
- From 52-week high
- −0.2%
- vs 50-day average
- +45.2%
- vs 200-day average
- +116.5%
- Volatility (1 year)
- 150%
- Beta vs S&P 500
- 1.67
Share price after results
- Next day
- 3 up, 4 down typical move ±7.5%
- After a week
- 5 up, 2 down typical move ±9.9%
- After a month
- 5 up, 2 down typical move ±16.0%
| Results released | Next day | S&P 500 next day | 5 days | 21 days |
|---|---|---|---|---|
| August 10, 2026 | +23.2% | −0.3% | +20.1% | +13.4% |
| May 7, 2026 | −5.3% | +0.5% | −3.1% | −15.4% |
| March 5, 2026 | +7.8% | −1.9% | +20.6% | +0.3% |
| November 6, 2025 | +5.4% | −1.0% | +10.9% | +10.7% |
| August 7, 2025 | −5.3% | +0.7% | +5.8% | +1.1% |
| May 8, 2025 | 0.0% | +0.6% | +8.4% | +43.5% |
| February 27, 2025 | −5.7% | −0.1% | −0.6% | −27.9% |
Fundamentals
Where the revenue comes from
| Line of business | Revenue | Share | YoY |
|---|---|---|---|
| Research Collaboration Income | $559,000 | 100.0% | ▼ 98.7% |
| Royalty Income | $0 | 0.0% | ▼ 100.0% |
From Silence Therapeutics plc's 10-K filed March 5, 2026, as tagged in the filing. View filing. Indented rows are part of the line above; their share is of that line. In the bars, the faint bar behind is the year before.
Who owns it
Funds buying and selling- Reported value
- $249M
- Institutions reporting
- 69
- Shares held vs prior quarter
- ▲ 14.0%
- Positions opened / closed
- 20 / 4
| Manager | Value | Shares | Share of 13F value | Shares QoQ |
|---|---|---|---|---|
| Siren, L.L.C. | $36.4M | 3.3M | 14.6% | ▲ 13.7% |
| Tcg Crossover Management, LLC | $33.3M | 3.0M | 13.4% | 0.0% |
| Nantahala Capital Management, LLC | $29.6M | 2.7M | 11.9% | ▲ 25.5% |
| Redmile Group, LLC | $23.8M | 2.2M | 9.5% | 0.0% |
| Citadel Advisors LLC | $14.6M | 1.3M | 5.9% | ▲ 7.7% |
| Nextech Invest Ltd. | $10.5M | 952K | 4.2% | 0.0% |
| Millennium Management LLC | $10M | 909K | 4.0% | ▼ 15.4% |
| Tetragon Partners Gp Ltd | $8.4M | 764K | 3.4% | ▲ 21.3% |
| Soleus Capital Management, L.P. | $6.9M | 630K | 2.8% | New |
| Balyasny Asset Management L.P. | $6.7M | 611K | 2.7% | New |
| 5Am Venture Management, LLC | $5.2M | 476K | 2.1% | 0.0% |
| Great Point Partners LLC | $4.9M | 450K | 2.0% | ▼ 55.9% |
From Form 13F filings with the SEC ( quarterly data sets), as reported by each manager for June 30, 2026 and filed up to 45 days later. 13F reports cover long US-listed positions of managers above $100M only, so this is not Silence Therapeutics plc's complete shareholder register. Values are as reported by the filers ; 2 inconsistently scaled filing rows were excluded.
Insider trading activity
Full insider history and chart Insider purchases History → $0 0 trades by 0 insiders, last 12 months Insider sales History → $0 0 trades by 0 insiders
Net ▲ $0 net buying
From insiders' Form 4 filings with the SEC. Excludes awards, option exercises and shares withheld for tax. "Pre-set plan" means the filing marks the trade as made under a Rule 10b5-1 plan. See every insider trade since five years ago, on a price chart.
Earnings dates and SEC filings
Results announcements
Next expected around November 5, 2026 estimated from the company's past filing pattern, not announced
- August 10, 2026
- May 7, 2026
- March 5, 2026
- November 6, 2025
- August 7, 2025
- May 8, 2025
Recent SEC filings
- 8-K Current report
- 8-K Current report
- 8-K Current report
- 10-Q Quarterly report
- 8-K Current report
- 8-K Current report
- 8-K Current report
- 8-K Current report
Data status
| Data | Last updated | Source |
|---|---|---|
| Share price | Exchange closing prices | |
| News and updates | Company releases and SEC 8-K filings | |
| Analyst estimates | Aggregated analyst estimates | |
| Valuation and scores | Our models, from the filed figures |
Silence Therapeutics plc in brief
- What does Silence Therapeutics plc do?
- Silence Therapeutics plc is a US-listed company in the biotechnology industry. Its financial year ends in December.
- What is Silence Therapeutics plc's stock ticker?
- Silence Therapeutics plc trades under the ticker SLN on Nasdaq. This page brings together its financial statements, valuation models, ownership and recent company updates.
- Who are Silence Therapeutics plc's largest institutional shareholders?
- By value reported in 13F filings for June 30, 2026, the largest reported holders are Siren, L.L.C., Tcg Crossover Management, LLC and Nantahala Capital Management, LLC. 13F reports cover long US-listed positions of managers above $100M, filed up to 45 days after quarter end.
- When is Silence Therapeutics plc's next earnings date?
- Around November 5, 2026, estimated from the spacing of its past results announcements (8-K filings). That is an estimate, not a confirmed date — Silence Therapeutics plc announces its own schedule.
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