Prime Medicine, Inc. cash flow statement

In fiscal 2025, Prime Medicine, Inc.'s operations generated −$163m of cash; it spent $4.5m on capital projects, leaving free cash flow of −$167m.

Cash flow statement

US$ millions unless shown otherwise. Fiscal years, plus the last twelve months (LTM) when newer.

Prime Medicine, Inc.: cash flow statement, annual
Fiscal year	2020Dec 2020	2021Dec 2021	2022Dec 2022	2023Dec 2023	2024Dec 2024	2025Dec 2025
Cash from operations	−6	−34	−132	−165	−123	−163
Depreciation and amortisation	0	1	2	5	6	7
Stock-based pay	0	2	6	14	26	29
Capital spending	1	4	16	9	7	5
Free cash flow	−6	−38	−148	−174	−130	−167
Free cash flow after stock pay	−7	−40	−154	−188	−156	−196
Shares issued	—	—	—	0	38	0

US$ millions unless shown otherwise. Fiscal quarters.

Prime Medicine, Inc.: cash flow statement, quarterly
Quarter	2024 Q1Mar 2024	2024 Q2Jun 2024	2024 Q3Sept 2024	2024 Q4Dec 2024	2025 Q1Mar 2025	2025 Q2Jun 2025	2025 Q3Sept 2025	2025 Q4Dec 2025
Cash from operations	−68	−45	−26	16	−49	−41	−35	−37
Depreciation and amortisation	1	2	2	2	2	2	2	2
Stock-based pay	5	8	7	6	6	6	13	5
Capital spending	2	2	1	2	2	2	0	0
Free cash flow	−70	−47	−27	14	−51	−43	−35	−38
Free cash flow after stock pay	−75	−55	−34	9	−57	−49	−48	−42
Shares issued	—	—	—	0	—	—	—	0

Free cash flow is cash from operations minus capital spending. Free cash flow after stock pay also subtracts stock-based compensation, a real cost to shareholders that the cash flow statement adds back. Dividends, buybacks and shares issued are cash amounts for the period.

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Figures from Prime Medicine, Inc.'s SEC filings (10-K and 10-Q), retrieved November 1, 2026. How we read and check them: methodology and data sources. Not investment advice. Back to Prime Medicine, Inc.