Rhythm Pharmaceuticals, Inc. key statistics and ratios

In fiscal 2025, Rhythm Pharmaceuticals, Inc. had an operating margin of -101.2%, debt equal to 77.8% of equity and a current ratio of 4.41. Each ratio below is calculated from the figures on its income statement, balance sheet and cash flow pages.

Financial ratios

US$ thousands unless shown otherwise. Fiscal years, plus the last twelve months (LTM) when newer.

Rhythm Pharmaceuticals, Inc.: financial ratios, annual
Fiscal year	2016Dec 2016	2017Dec 2017	2018Dec 2018	2019Dec 2019	2020Dec 2020	2021Dec 2021	2022Dec 2022	2023Dec 2023	2024Dec 2024	2025Dec 2025	LTMJun 2026
Gross margin	—	—	—	—	—	81.0%	91.0%	88.0%	89.7%	89.7%	89.0%
Operating margin	—	—	—	—	—	<−999%	−757.9%	−238.1%	−204.0%	−101.2%	−83.6%
Net margin	—	—	—	—	—	<−999%	−766.2%	−238.5%	−200.3%	−103.6%	−85.6%
Free-cash-flow margin	—	—	—	—	—	<−999%	−734.9%	−175.9%	−87.5%	−61.5%	−43.9%
Return on equity	—	−60.1%	−37.9%	−53.4%	−59.9%	−30.9%	−66.1%	−85.1%	—	—	−169.7%
Return on assets	−235.6%	−41.1%	−36.0%	−49.5%	−54.1%	−27.0%	−50.9%	−51.6%	−71.9%	−45.1%	−44.8%
Asset turnover	—	—	—	—	—	0.01	0.07	0.22	0.36	0.43	0.52
Current ratio	2.36	22.42	19.05	12.38	10.10	7.10	8.90	5.58	3.24	4.41	3.45
Debt to equity	—	0.0%	0.0%	0.0%	0.0%	0.0%	27.6%	62.5%	505.4%	77.8%	103.0%
Interest cover (operating income ÷ interest)	—	—	—	—	—	—	n/m	n/m	n/m	n/m	n/m
R&D as % of revenue	—	—	—	—	—	>999%	459.6%	174.3%	182.9%	88.2%	72.2%
SG&A as % of revenue	—	—	—	—	—	>999%	389.3%	151.8%	110.9%	102.7%	100.4%
Capital spending as % of revenue	—	—	—	—	—	13.8%	1.2%	0.1%	0.0%	0.5%	0.0%

US$ thousands unless shown otherwise. Fiscal quarters.

Rhythm Pharmaceuticals, Inc.: financial ratios, quarterly
Quarter	2024 Q3Sept 2024	2024 Q4Dec 2024	2025 Q1Mar 2025	2025 Q2Jun 2025	2025 Q3Sept 2025	2025 Q4Dec 2025	2026 Q1Mar 2026	2026 Q2Jun 2026
Gross margin	88.5%	90.9%	88.8%	88.6%	89.3%	91.6%	88.1%	87.5%
Operating margin	−132.0%	−98.6%	−143.7%	−93.4%	−102.6%	−82.2%	−87.1%	−68.1%
Net margin	−131.2%	−103.5%	−151.4%	−96.1%	−103.1%	−83.0%	−92.6%	−69.2%
Free-cash-flow margin	−75.8%	−45.1%	−123.4%	−48.1%	−51.9%	−44.3%	−73.5%	−12.8%
Current ratio	3.49	3.24	3.30	2.79	4.75	4.41	4.17	3.45
Debt to equity	—	505.4%	578.1%	—	73.2%	77.8%	88.3%	103.0%
R&D as % of revenue	114.1%	98.4%	113.1%	87.2%	89.7%	73.4%	69.4%	60.9%
SG&A as % of revenue	106.4%	91.2%	119.5%	94.7%	102.2%	100.4%	105.8%	94.7%

Returns use average equity or assets over the year. Return on equity is left blank when equity is negative or so small that the ratio says nothing (above ±200%); interest cover is left blank above 200 times. Price-based ratios such as P/E are on the valuation page.

Financial health

2 of 6 checks passed · June 30, 2026

What it owns · $437m

Short-term assets $427mLonger-term assets $11m

What it owes, and who funded it · $323m

Short-term liabilities $124mLonger-term liabilities $96mShareholders' equity $103m

Short-term assets cover short-term liabilities $427m of assets due within a year against $124m of liabilities due within a year.
Short-term assets cover long-term liabilities $427m short-term assets against $96m of longer-dated liabilities.
More cash than debt $66m of cash against $106m of debt.
Debt below 40% of shareholders' equity Debt is 103% of equity.
Debt burden no higher than five years ago Five-year comparison not available. Not assessable.
A year's operating cash flow covers at least 20% of debt −$105m of operating cash flow against $106m of debt.
Operating profit covers interest at least five times over Operating income of −$201m against $18m of interest.

From Rhythm Pharmaceuticals, Inc.'s latest balance sheet as filed. Checks are fixed, documented rules (methodology), counted only where the company reports the figures — a dot means the filing doesn't break the item out. Descriptions of reported data, not advice.

Moat

25 /100

Weak moat

How hard Rhythm Pharmaceuticals's competitive advantage looks for rivals to wear away, judged from 9 years of its own filings: returns on capital, pricing power, profit durability, cash conversion and discipline.

Returns on capital 0 / 20

Net income has been a median -54.5% of total assets over 9 years.
Pricing power 20 / 20

Gross margin has been a median 89.0%, moving by 1.3 percentage points (standard deviation) across 5 years.
Durability 10 / 20

Operating margin has been a median -260.9%; its worst year was -1439.5%.
Cash conversion 0 / 20

Free cash flow was positive in 0 of 5 years, at a median -126.2% of revenue.
Discipline 0 / 20

The diluted share count rose 44.2% over five years; stock-based pay has been a median 36.4% of revenue.

AI disruption exposure: Medium. In this industry, AI could change how the product is made or sold, without replacing the core asset. The score above includes a 5-point deduction for that exposure (30 before it).

A rules-based reading of reported figures, not a forecast and not investment advice. How the score is built: methodology.

Compare with peers

Head to head: ANAB vs RYTM IDYA vs RYTM PBYI vs RYTM LGND vs RYTM

More: Biotechnology stocks compared, Health Care sector, rankings of US companies

Figures from Rhythm Pharmaceuticals, Inc.'s SEC filings (10-K and 10-Q), retrieved October 29, 2026. How we read and check them: methodology and data sources. Not investment advice. Back to Rhythm Pharmaceuticals, Inc.