Spero Therapeutics, Inc. insider trading

Does following Spero Therapeutics, Inc.’s insiders pay?

From July 17, 2018 to May 6, 2026, 9 insiders reported 18 open-market purchases and 26 sales not made under a pre-set plan in Spero Therapeutics, Inc. Twelve months after each purchase was reported, the shares were −74.1% against the S&P 500 on average (median −77.2%), over 17 purchases with a full year of prices; 0% beat the index. After sales, the shares moved −42.4% against the index over 12 months (a negative figure means selling was the right call). That rests on fewer than 20 purchases, too few to read much into. Buying each purchase the day after it was reported, an equal amount each, held 12 months or until that insider reported a sale, would have turned $10,000 on July 18, 2018 into $860 by November 2, 2026, −25.7% a year. It held shares 31% of the time; the S&P 500 on those same days, with Treasury bills otherwise, made $11,581 (+1.8% a year), and held throughout $30,475 (+14.4%).

Moves are the shares’ return including dividends minus the S&P 500’s, from the close on the first trading day after each report; the number of trades with a finished 12-month window is in brackets. Green means the trade went the insider’s way (a purchase ahead of the index, a sale followed by the shares trailing it). A trade reported both by a director or officer and by a fund or company they are linked to counts once here, under the person. Purchases count only where the share price actually traded was at least $5. These figures describe what the shares did, not why anyone traded. Insiders across all companies.