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Funds (13F)

Logos Global Management LP

Backtest from 21 Feb 2020 to 2 Nov 2026 · weekly · hypothetical

Watch this strategy
Return a year
−3.2%
S&P 500 +14.6%
Last 12 months
+34.2%
S&P 500 +12.1%
Sharpe ratio
0.05
S&P 500 0.66
Biggest drop
−82.3%
S&P 500 −31.0%
$5.0k$10.0k$20.0k 2020202120222023202420252026 $24.9k$8.0k
Logos Global Management LPS&P 500 $10,000 in Logos Global Management LP from 21 Feb 2020 against the S&P 500 (total return) over the same dates, marked weekly, log scale. Hypothetical: before taxes and trading costs.

About

Copies Logos Global Management LP's quarterly 13F holdings in the companies we cover, weighted by reported value: it buys on the first trading day after each 13F is filed (up to 45 days after the quarter) and holds until the next filing. A 13F shows long US-listed positions only, at the quarter's end, so this misses shorts, cash, bonds, non-US holdings and trading within the quarter.

Logos Global Management LP's 13F holdings →

Key statistics

MeasureStrategyS&P 500
Return a year (compound)−3.2%+14.6%
Total return−20%+149%
Last 12 months+34.2%+12.1%
Last 3 months−17.6%—
Last month−7.2%—
This year so far+10.9%—
Volatility a year40.6%18.9%
Sharpe ratio0.050.66
Biggest drop−82.3%−31.0%
Beta to the S&P 5001.091.00
Alpha a year (t-statistic)−11.4% (−0.84)—
Share of weeks up50%—

Sharpe ratio uses returns above the 3-month Treasury bill rate. Alpha is the yearly return left after allowing for the strategy's exposure to the S&P 500 (CAPM); a t-statistic below about 2 means it cannot be told apart from luck.

Insights

CompanyWeightHeld sinceReturn since
ERAS9.6%——
ABVX5.9%——
RVMD5.7%——
IDYA4.8%——
BNTX4.1%——
VERA4.1%——
TNGX3.8%——
PRAX3.8%——
CLDX3.4%——
DNTH3.4%——
CGON3.1%——
IRON2.8%——
MAZE2.5%——
DYN2.4%——
MLTX2.2%——
OCUL2.2%——
DSGN1.9%——
OLMA1.7%——
BLTE1.7%——
ACHV1.5%——
TRVI1.5%——
COGT1.5%——
AVBP1.5%——
CBIO1.5%——
CMPS1.4%——
MLYS1.2%——
REPL1.2%——
XENE1.2%——
GPCR1.2%——
IMVT1.1%——
JBIO1.1%——
ELVN1.0%——
MANE0.9%——
AVTX0.9%——
RCUS0.9%——
SMMT0.8%——
IMCR0.8%——
LBRX0.8%——
NERV0.8%——
FTH0.8%——
CRSP0.7%——
DBVT0.7%——
PBLS0.6%——
RYTM0.6%——
VOR0.5%——
SRRK0.5%——
IMMX0.4%——
QTTB0.4%——
ODTX0.4%——
ANNX0.4%——
EDIT0.3%——
RLAY0.3%——
ACAD0.3%——
AMLX0.3%——
HELP0.2%——
OKUR0.2%——
TENX0.2%——
DFTX0.2%——
UNCY0.1%——
PTN0.1%——
QURE0.1%——
RACC0.1%——
ACRS0.1%——
LGVN0.0%——
GUTS0.0%——
SEPN0.0%——

Weighted by reported value in the latest 13F, held until the next filing.

PeriodReturn a yearS&P 500SharpeS&P 500Biggest dropBetaAlpha (t)
Whole backtest21 Feb 2020 to 2 Nov 2026−3.2%+14.6%0.050.66−82.3%1.09−11.4% (−0.84)
Last three years3 Nov 2023 to 2 Nov 2026+19.6%+21.8%0.551.16−49.4%1.28−0.8% (−0.05)
Last year7 Nov 2025 to 2 Nov 2026+40.0%+14.2%0.980.84−26.2%1.26+23.3% (0.69)
DateCompanyAction
21 Aug 2026VERABought
21 Aug 2026SRRKBought
21 Aug 2026SMMTBought
21 Aug 2026REPLBought
21 Aug 2026RACCBought
21 Aug 2026QUREBought
21 Aug 2026QTTBBought
21 Aug 2026PBLSBought
21 Aug 2026OKURBought
21 Aug 2026ODTXBought
21 Aug 2026MLYSBought
21 Aug 2026LGVNBought
21 Aug 2026HELPBought
21 Aug 2026EDITBought
21 Aug 2026DFTXBought
21 Aug 2026DBVTBought
21 Aug 2026CRSPBought
21 Aug 2026COGTBought
21 Aug 2026CMPSBought
21 Aug 2026BNTXBought
21 Aug 2026BLTEBought
21 Aug 2026ANNXBought
21 Aug 2026ACHVBought
22 May 2026XENEBought
22 May 2026UTHRBought

Dated at the rebalance that made the change.

DateCompanyAction
21 Aug 2026VSTMSold
21 Aug 2026UTHRSold
21 Aug 2026TYRASold
21 Aug 2026PHVSSold
21 Aug 2026PCVXSold
21 Aug 2026ORICSold
21 Aug 2026NAMSSold
21 Aug 2026MIRMSold
21 Aug 2026MGTXSold
21 Aug 2026MDGLSold
21 Aug 2026JANXSold
21 Aug 2026IBIOSold
21 Aug 2026CYTKSold
21 Aug 2026CRVSSold
21 Aug 2026CMPXSold
21 Aug 2026BIIBSold
21 Aug 2026ALKSSold
22 May 2026QURESold
22 May 2026NRIXSold
22 May 2026NGNESold
22 May 2026MREOSold
22 May 2026KYMRSold
22 May 2026KNSASold
22 May 2026JAZZSold
22 May 2026DBVTSold

Dated at the rebalance that made the change.

Backtests are hypothetical and use today's listed companies only, which flatters results. Past performance does not predict future returns. This is research, not investment advice. How we backtest