Upstream Bio, Inc. cash flow statement

In fiscal 2025, Upstream Bio, Inc.'s operations generated −$133m of cash; it spent $165,000 on capital projects, leaving free cash flow of −$133m.

Cash flow statement

US$ millions unless shown otherwise. Fiscal years, plus the last twelve months (LTM) when newer.

Upstream Bio, Inc.: cash flow statement, annual
Fiscal year	2023Dec 2023	2024Dec 2024	2025Dec 2025	LTMJun 2026
Cash from operations	−38	−59	−133	−136
Depreciation and amortisation	0	0	0	0
Stock-based pay	3	6	10	14
Capital spending	0	1	0	—
Free cash flow	−38	−60	−133	—
Free cash flow after stock pay	−41	−66	−144	—

US$ millions unless shown otherwise. Fiscal quarters.

Upstream Bio, Inc.: cash flow statement, quarterly
Quarter	2024 Q3Sept 2024	2024 Q4Dec 2024	2025 Q1Mar 2025	2025 Q2Jun 2025	2025 Q3Sept 2025	2025 Q4Dec 2025	2026 Q1Mar 2026	2026 Q2Jun 2026
Cash from operations	−14	−20	−41	−39	−22	−31	−48	−36
Depreciation and amortisation	0	0	0	0	0	0	0	0
Stock-based pay	2	2	3	3	3	3	5	4
Capital spending	—	0	—	—	0	0	—	0
Free cash flow	—	−20	—	—	−22	−31	—	−36
Free cash flow after stock pay	—	−22	—	—	−25	−33	—	−40
Shares issued	—	—	—	—	—	—	669	−667

Free cash flow is cash from operations minus capital spending. Free cash flow after stock pay also subtracts stock-based compensation, a real cost to shareholders that the cash flow statement adds back. Dividends, buybacks and shares issued are cash amounts for the period.

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Figures from Upstream Bio, Inc.'s SEC filings (10-K and 10-Q), retrieved October 29, 2026. How we read and check them: methodology and data sources. Not investment advice. Back to Upstream Bio, Inc.