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Funds (13F)

Casdin Capital, LLC

Backtest from 12 Feb 2016 to 2 Nov 2026 · weekly · hypothetical

Watch this strategy
Return a year
+6.2%
S&P 500 +15.8%
Last 12 months
+20.7%
S&P 500 +12.1%
Sharpe ratio
0.29
S&P 500 0.82
Biggest drop
−77.5%
S&P 500 −31.8%
$10.0k$20.0k$40.0k 201620182020202220242026 $48.2k$19.1k
Casdin Capital, LLCS&P 500 $10,000 in Casdin Capital, LLC from 12 Feb 2016 against the S&P 500 (total return) over the same dates, marked weekly, log scale. Hypothetical: before taxes and trading costs.

About

Copies Casdin Capital, LLC's quarterly 13F holdings in the companies we cover, weighted by reported value: it buys on the first trading day after each 13F is filed (up to 45 days after the quarter) and holds until the next filing. A 13F shows long US-listed positions only, at the quarter's end, so this misses shorts, cash, bonds, non-US holdings and trading within the quarter.

Casdin Capital, LLC's 13F holdings →

Key statistics

MeasureStrategyS&P 500
Return a year (compound)+6.2%+15.8%
Total return+91%+382%
Last 12 months+20.7%+12.1%
Last 3 months−1.2%—
Last month−9.9%—
This year so far+7.5%—
Volatility a year40.2%16.7%
Sharpe ratio0.290.82
Biggest drop−77.5%−31.8%
Beta to the S&P 5001.361.00
Alpha a year (t-statistic)−6.8% (−0.67)—
Share of weeks up51%—

Sharpe ratio uses returns above the 3-month Treasury bill rate. Alpha is the yearly return left after allowing for the strategy's exposure to the S&P 500 (CAPM); a t-statistic below about 2 means it cannot be told apart from luck.

Insights

CompanyWeightHeld sinceReturn since
RVMD25.9%——
RLAY16.1%——
WGS13.6%——
ILMN5.0%——
LAB3.9%——
GPCR3.4%——
DNLI2.8%——
NGNE2.6%——
BEAM2.5%——
TXG2.2%——
SRRK2.0%——
PSNL1.8%——
GRAL1.8%——
GH1.5%——
MAZE1.4%——
HIMS1.3%——
ALNY1.2%——
TSHA1.2%——
AGMB1.1%——
SEPN1.0%——
PBLS0.9%——
SION0.9%——
VCYT0.9%——
ANL0.8%——
PRME0.6%——
ABSI0.6%——
DGX0.6%——
SRPT0.5%——
QURE0.4%——
NTLA0.3%——
MRNA0.3%——
IRON0.3%——
GLUE0.2%——
IPSC0.2%——
CTNM0.1%——
BBOT0.1%——
EDIT0.1%——
PACB0.1%——
KARD0.1%——
RXRX0.0%——
DNA0.0%——
TNYA0.0%——

Weighted by reported value in the latest 13F, held until the next filing.

PeriodReturn a yearS&P 500SharpeS&P 500Biggest dropBetaAlpha (t)
Whole backtest12 Feb 2016 to 2 Nov 2026+6.2%+15.8%0.290.82−77.5%1.36−6.8% (−0.67)
2018 onwards5 Jan 2018 to 2 Nov 2026+2.2%+13.9%0.190.66−77.5%1.32−7.8% (−0.69)
Last three years3 Nov 2023 to 2 Nov 2026+25.2%+21.8%0.651.16−43.5%1.45+2.3% (0.11)
Last year7 Nov 2025 to 2 Nov 2026+24.9%+14.2%0.650.84−31.6%1.52+10.6% (0.29)
DateCompanyAction
21 Aug 2026SRPTBought
21 Aug 2026SIONBought
21 Aug 2026QUREBought
21 Aug 2026PBLSBought
21 Aug 2026KARDBought
21 Aug 2026EDITBought
22 May 2026QGENBought
22 May 2026PSNLBought
22 May 2026NTLABought
22 May 2026MRNABought
22 May 2026MLTXBought
22 May 2026IRONBought
22 May 2026GRALBought
22 May 2026ANLBought
22 May 2026AGMBBought
20 Feb 2026TXGBought
20 Feb 2026TSHABought
20 Feb 2026SRRKBought
20 Feb 2026LEGNBought
20 Feb 2026DXCMBought
20 Feb 2026DGXBought
20 Feb 2026CIBought
21 Nov 2025UNHBought
21 Nov 2025TEMBought
21 Nov 2025SPRYBought

Dated at the rebalance that made the change.

DateCompanyAction
21 Aug 2026TEMSold
21 Aug 2026QGENSold
21 Aug 2026MLTXSold
22 May 2026UNHSold
22 May 2026SPRYSold
22 May 2026LEGNSold
22 May 2026INCYSold
22 May 2026DXCMSold
22 May 2026CISold
21 Nov 2025SRPTSold
21 Nov 2025SNDXSold
21 Nov 2025LLYSold
21 Nov 2025CDXSSold
21 Nov 2025AGIOSold
15 Aug 2025VSTMSold
15 Aug 2025TNGXSold
15 Aug 2025TDOCSold
15 Aug 2025SLDBSold
15 Aug 2025ONCSold
15 Aug 2025NTLASold
15 Aug 2025MRNASold
15 Aug 2025GEHCSold
15 Aug 2025DYNSold
16 May 2025FTRESold
16 May 2025FDMTSold

Dated at the rebalance that made the change.

Backtests are hypothetical and use today's listed companies only, which flatters results. Past performance does not predict future returns. This is research, not investment advice. How we backtest