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NRX Pharmaceuticals vs Upstream Bio

Upstream Bio is the larger business, with $2.9m of revenue in fiscal 2025 against $1.2m for NRX Pharmaceuticals (2.3 times as much). NRX Pharmaceuticals kept more of each dollar of sales as profit: a net margin of -2336.5% against -5026.0%.

Latest fiscal yearNRX PharmaceuticalsNRXP, 2025Upstream BioUPB, 2025
Revenue $1.2m $2.9m
Revenue growth — 20.4%
Net income −$28.6m −$143m
Operating margin — -5618.8%
Net margin -2336.5% -5026.0%
Return on equity — -35.4%
Free cash flow −$14.1m −$133m
Cash $7.8m $102m
Total debt $0 $0
Debt to equity — 0.0%
Dividend per share — —
Dividend yield — —
Share buybacks — —
Employees 29 75
Market value $100m $182m
Price vs our value range — —
Moat score — —
Insider trades, 12 months 0 buys, 0 sales 0 buys, 15 sales

Each figure is from the company's latest annual report and links to the page it comes from. Fiscal years can end on different dates. Market value and the value verdict use the delayed price shown on the stock pages. Not a recommendation.

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Figures from each company's latest annual report filed with the SEC (10-K or 20-F), as reported, with the fiscal year shown. Not investment advice. How we read filings: methodology.