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Biocryst Pharmaceuticals vs Ionis Pharmaceuticals

Biocryst Pharmaceuticals and Ionis Pharmaceuticals are similar in size: $875m and $944m of revenue in their latest fiscal years. Biocryst Pharmaceuticals grew faster (94.1% against 33.8%). Biocryst Pharmaceuticals kept more of each dollar of sales as profit: a net margin of 30.2% against -40.4%.

Latest fiscal yearBiocryst PharmaceuticalsBCRX, 2025Ionis PharmaceuticalsIONS, 2025
Revenue $875m $944m
Revenue growth 94.1% 33.8%
Net income $264m −$381m
Operating margin 39.0% -40.4%
Net margin 30.2% -40.4%
Return on equity — -70.8%
Free cash flow $345m −$320m
Cash $89.7m $372m
Total debt $0 $1.81bn
Debt to equity — 370.6%
Dividend per share — —
Dividend yield — —
Share buybacks — —
Employees 435 1,402
Market value $2.19bn $6.75bn
Price vs our value range Below our value range —
Moat score 46 (Moderate) 35 (Weak)
Insider trades, 12 months 0 buys, 10 sales 2 buys, 116 sales

Each figure is from the company's latest annual report and links to the page it comes from. Fiscal years can end on different dates. Market value and the value verdict use the delayed price shown on the stock pages. Not a recommendation.

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Figures from each company's latest annual report filed with the SEC (10-K or 20-F), as reported, with the fiscal year shown. Not investment advice. How we read filings: methodology.