undamentalytics Newsletter

Ionis Pharmaceuticals Inc revenue

Ionis Pharmaceuticals Inc's revenue was $944m in fiscal 2025, up 33.8% on the year before. Since fiscal 2009 ($122m) it has grown at a compound 13.7% a year. Over the last twelve months it was $874m.

Revenue history

US$ millions unless shown otherwise. Fiscal years, plus the last twelve months (LTM) when newer.

Ionis Pharmaceuticals Inc: revenue history, annual
Fiscal year2009Dec 20092010Dec 20102011Dec 20112012Dec 20122013Dec 20132014Dec 20142015Dec 20152016Dec 20162017Dec 20172018Dec 20182019Dec 20192020Dec 20202021Dec 20212022Dec 20222023Dec 20232024Dec 20242025Dec 2025LTMJun 2026
Revenue122108991021472142843475086001,123729810587788705944874
Growth on the year before—−10.8%−8.7%+3.0%+44.3%+45.4%+32.5%+22.2%+46.5%+18.1%+87.2%−35.0%+11.1%−27.5%+34.1%−10.5%+33.8%—
Gross profit———————3475085981,118717800573779694928858
Gross margin———————100.0%100.0%99.7%99.6%98.4%98.7%97.6%98.8%98.4%98.3%98.2%

Revenue as reported in the company's 10-K and 10-Q filings (for banks, net interest income plus non-interest income). Growth is left blank when the earlier figure was zero or negative.

Where the revenue comes from

Fiscal year to December 31, 2025
Products and services
Line of business Revenue YoY
Research and Development Revenue $508M ▲ 23.2%
Collaborative Agreement Revenue $466M ▲ 40.0%
Commercial $436M ▲ 48.7%
Royalty $286M ▲ 11.0%
Spinraza Royalties $212M ▼ 1.8%
Products $115M —
Tryngolza Sales $108M —
Wainus Royalties $49.1M ▲ 142.9%
Wainua Joint Development Revenue $42.1M ▼ 47.0%
Other Commercial $35M ▼ 2.1%
Other Royalties $24.2M ▲ 15.0%
Dawnzera Sales $7.8M —

These categories overlap or exclude eliminations, so shares aren't shown.

From Ionis Pharmaceuticals Inc's 10-K filed February 26, 2026, as tagged in the filing. View filing. Indented rows are part of the line above; their share is of that line. In the bars, the faint bar behind is the year before.

Revenue against peers

Biotechnology: the closest covered companies by revenue. Last twelve months.

CompanyRevenueGrowth3-year growth a year
Ionis Pharmaceuticals Inc $874m -7.4% 11.5%
Ascendis Pharma A/s $814m 106.9% —
Biocryst Pharmaceuticals Inc $941m 68.7% 45.3%
Bridgebio Pharma, Inc. $946m 167.3% 364.6%
Kiniksa Pharmaceuticals International, plc $946m 58.2% 56.1%
Telix Pharmaceuticals Ltd $804m 55.6% —

Compare with peers

Head to head: ASND vs IONSBCRX vs IONSBBIO vs IONSIONS vs KNSA

More: Biotechnology stocks compared, Health Care sector, rankings of US companies

Figures from Ionis Pharmaceuticals Inc's SEC filings (10-K and 10-Q), retrieved October 20, 2026. How we read and check them: methodology and data sources. Not investment advice. Back to Ionis Pharmaceuticals Inc.