Ascendis Pharma A/s vs Ionis Pharmaceuticals
Ionis Pharmaceuticals is the larger business, with $944m of revenue in fiscal 2025 against $814m for Ascendis Pharma A/s (1.2 times as much). Ascendis Pharma A/s grew faster (106.9% against 33.8%). Ascendis Pharma A/s kept more of each dollar of sales as profit: a net margin of -31.7% against -40.4%.
| Latest fiscal year | Ascendis Pharma A/sASND, 2025 | Ionis PharmaceuticalsIONS, 2025 |
|---|---|---|
| Revenue | $814m | $944m |
| Revenue growth | 106.9% | 33.8% |
| Net income | −$258m | −$381m |
| Operating margin | -18.9% | -40.4% |
| Net margin | -31.7% | -40.4% |
| Return on equity | — | -70.8% |
| Free cash flow | $60.9m | −$320m |
| Cash | $723m | $372m |
| Total debt | $956m | $1.81bn |
| Debt to equity | — | 370.6% |
| Dividend per share | — | — |
| Dividend yield | — | — |
| Share buybacks | $19.7m | — |
| Employees | — | 1,402 |
| Market value | $15.18bn | $6.75bn |
| Price vs our value range | — | — |
| Moat score | — | 35 (Weak) |
| Insider trades, 12 months | 9 buys, 3 sales | 2 buys, 116 sales |