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Funds (13F)

Perceptive Advisors LLC

Backtest from 16 Aug 2013 to 2 Nov 2026 · weekly · hypothetical

Watch this strategy
Return a year
+10.9%
S&P 500 +14.1%
Last 12 months
+13.1%
S&P 500 +12.1%
Sharpe ratio
0.41
S&P 500 0.78
Biggest drop
−75.6%
S&P 500 −31.8%
$10.0k$20.0k$40.0k 2013201520172019202120232025 $57.0k$39.4k
Perceptive Advisors LLCS&P 500 $10,000 in Perceptive Advisors LLC from 16 Aug 2013 against the S&P 500 (total return) over the same dates, marked weekly, log scale. Hypothetical: before taxes and trading costs.

About

Copies Perceptive Advisors LLC's quarterly 13F holdings in the companies we cover, weighted by reported value: it buys on the first trading day after each 13F is filed (up to 45 days after the quarter) and holds until the next filing. A 13F shows long US-listed positions only, at the quarter's end, so this misses shorts, cash, bonds, non-US holdings and trading within the quarter.

Perceptive Advisors LLC's 13F holdings →

Key statistics

MeasureStrategyS&P 500
Return a year (compound)+10.9%+14.1%
Total return+294%+470%
Last 12 months+13.1%+12.1%
Last 3 months−5.8%—
Last month−3.9%—
This year so far+5.1%—
Volatility a year37.4%16.0%
Sharpe ratio0.410.78
Biggest drop−75.6%−31.8%
Beta to the S&P 5001.131.00
Alpha a year (t-statistic)+1.3% (0.15)—
Share of weeks up53%—

Sharpe ratio uses returns above the 3-month Treasury bill rate. Alpha is the yearly return left after allowing for the strategy's exposure to the S&P 500 (CAPM); a t-statistic below about 2 means it cannot be told apart from luck.

Insights

CompanyWeightHeld sinceReturn since
PRAX11.3%——
SYRE6.4%——
CELC5.5%——
ASND5.2%——
RYTM4.8%——
ROIV4.8%——
RLAY4.4%——
TVTX3.5%——
KARD3.3%——
EWTX3.0%——
AMLX2.5%——
MGTX2.4%——
ORKA2.1%——
INBX2.0%——
PTGX2.0%——
SLDB2.0%——
ZYME1.8%——
TNGX1.8%——
IMTX1.8%——
NRIX1.7%——
BCRX1.7%——
RVMD1.6%——
AVLN1.5%——
DYN1.0%——
BIIB1.0%——
IMVT0.9%——
UNH0.8%——
IONS0.8%——
STRO0.7%——
ANRO0.7%——
JAZZ0.7%——
CRVS0.7%——
SION0.7%——
CTMX0.7%——
AORT0.7%——
XFOR0.6%——
CORT0.6%——
RGEN0.6%——
AVR0.6%——
RAPP0.5%——
CRL0.5%——
AXSM0.5%——
DBVT0.5%——
IRTC0.4%——
ADPT0.4%——
SABS0.4%——
DHR0.4%——
TENX0.4%——
NAUT0.4%——
OBIO0.4%——
ISRG0.3%——
ANL0.3%——
CTNM0.3%——
NVCT0.3%——
PALI0.3%——
OMDA0.3%——
LONA0.3%——
EOLS0.3%——
IVVD0.3%——
MIRM0.2%——
SRZN0.2%——
BBNX0.2%——
AXGN0.2%——
OSCR0.2%——
OCS0.2%——
SPTX0.2%——
VRDN0.2%——
BSX0.2%——
BLLN0.2%——
ABVX0.2%——
NTRA0.2%——
ENGN0.1%——
RACC0.1%——
AGMB0.1%——
CGEM0.1%——
QURE0.1%——
MOBI0.1%——
ADGM0.1%——
GH0.1%——
PHAT0.1%——
OTLK0.1%——
COGT0.1%——
EDSA0.1%——
AVTX0.1%——
TWST0.1%——
CBIO0.1%——
XERS0.1%——
OM0.1%——
BDSX0.0%——
CNTB0.0%——
MDLN0.0%——
ADMA0.0%——
CPIX0.0%——
XGN0.0%——
ENSC0.0%——

Weighted by reported value in the latest 13F, held until the next filing.

PeriodReturn a yearS&P 500SharpeS&P 500Biggest dropBetaAlpha (t)
Whole backtest16 Aug 2013 to 2 Nov 2026+10.9%+14.1%0.410.78−75.6%1.13+1.3% (0.15)
2018 onwards5 Jan 2018 to 2 Nov 2026+3.4%+13.9%0.190.66−75.6%1.10−6.0% (−0.60)
Last three years3 Nov 2023 to 2 Nov 2026+23.3%+21.8%0.661.16−47.5%1.31+1.0% (0.06)
Last year7 Nov 2025 to 2 Nov 2026+21.2%+14.2%0.650.84−23.7%1.13+8.3% (0.30)
DateCompanyAction
21 Aug 2026XERSBought
21 Aug 2026UNHBought
21 Aug 2026SPTXBought
21 Aug 2026RACCBought
21 Aug 2026QUREBought
21 Aug 2026OTLKBought
21 Aug 2026OSCRBought
21 Aug 2026NVCTBought
21 Aug 2026NTRABought
21 Aug 2026MOBIBought
21 Aug 2026MIRMBought
21 Aug 2026KARDBought
21 Aug 2026ENGNBought
21 Aug 2026DHRBought
21 Aug 2026CRLBought
21 Aug 2026CGEMBought
21 Aug 2026BSXBought
21 Aug 2026BIIBBought
21 Aug 2026BDSXBought
21 Aug 2026AVLNBought
21 Aug 2026ASNDBought
21 Aug 2026ANLBought
5 Jun 2026XGNBought
5 Jun 2026TWSTBought
5 Jun 2026STROBought

Dated at the rebalance that made the change.

DateCompanyAction
21 Aug 2026PTNSold
21 Aug 2026NMRASold
21 Aug 2026NBIXSold
21 Aug 2026IRDSold
21 Aug 2026IKTSold
21 Aug 2026EVMNSold
21 Aug 2026DRUGSold
21 Aug 2026BLTESold
5 Jun 2026XENESold
5 Jun 2026SVRASold
5 Jun 2026SEPNSold
5 Jun 2026SDGRSold
5 Jun 2026PVLASold
5 Jun 2026PEPGSold
5 Jun 2026PENSold
5 Jun 2026OLMASold
5 Jun 2026MPLTSold
5 Jun 2026MIRMSold
5 Jun 2026LXEOSold
5 Jun 2026LENZSold
5 Jun 2026KYMRSold
5 Jun 2026KRYSSold
5 Jun 2026KODSold
5 Jun 2026KMTSSold
5 Jun 2026IRONSold

Dated at the rebalance that made the change.

Backtests are hypothetical and use today's listed companies only, which flatters results. Past performance does not predict future returns. This is research, not investment advice. How we backtest