undamentalytics Newsletter

Hedge fund

RTW Investments, LP

13F for the quarter to June 30, 2026, filed August 14, 2026 · SEC CIK 1493215

Reported value
$11.7bn
100% in companies we cover
Positions we cover
80
Largest MDGL 9.1%
Copy, a year
+6.9%
S&P 500 +13.4%
Copy Sharpe ratio
0.31
S&P 500 0.71

How copying its 13F would have done

$5.0k$10.0k$20.0k$40.0k 201520172019202120232025 $43.5k$21.7k
CopyS&P 500 $10,000 copying RTW Investments, LP's filed holdings in companies we cover from February 20, 2015, buying on the first trading day after each 13F was filed and holding until the next, against the S&P 500 (total return). Marked weekly, log scale. Before costs and taxes; misses trading within each quarter and anything 13F does not show (shorts, cash, bonds, non-US holdings).

Biggest drop −63.8% (S&P 500 −31.8%); beta 1.16; alpha −2.1% a year (t = −0.23); last 12 months +6.2% against +12.1%.

Reported value by quarter

RTW Investments, LP: 13F reported value Total value of all positions in each quarter's 13F, as filed (values before 2023 were filed in thousands of dollars and are converted).
$0 $2T $4T $6T Reported value, 2014-12-31: $270.3M Reported value, 2015-03-31: $221.5M Reported value, 2015-06-30: $337.1M Reported value, 2015-09-30: $318.7M Reported value, 2015-12-31: $307.2M Reported value, 2016-03-31: $274.5M Reported value, 2016-06-30: $291.8M Reported value, 2016-09-30: $329.6M Reported value, 2016-12-31: $265.4M Reported value, 2017-03-31: $379.9M Reported value, 2017-06-30: $474.4M Reported value, 2017-09-30: $574.2M Reported value, 2017-12-31: $599.1M Reported value, 2018-03-31: $1.1B Reported value, 2018-06-30: $1.4B Reported value, 2018-09-30: $1.7B Reported value, 2018-12-31: $1.1B Reported value, 2019-03-31: $1.5B Reported value, 2019-06-30: $1.9B Reported value, 2019-09-30: $1.7B Reported value, 2019-12-31: $2.7B Reported value, 2020-03-31: $2.3B Reported value, 2020-06-30: $3.6B Reported value, 2020-09-30: $4.2B Reported value, 2020-12-31: $6B Reported value, 2021-03-31: $6.4B Reported value, 2021-06-30: $6.6B Reported value, 2021-09-30: $6.6B Reported value, 2021-12-31: $6.8B Reported value, 2022-03-31: $4.8B Reported value, 2022-06-30: $3.9B Reported value, 2022-09-30: $4.3B Reported value, 2022-12-31: $4.9T Reported value, 2023-03-31: $4.8B Reported value, 2023-06-30: $5.3B Reported value, 2023-09-30: $4.7B Reported value, 2023-12-31: $6.4B Reported value, 2024-03-31: $6.8B Reported value, 2024-06-30: $6.5B Reported value, 2024-09-30: $6.9B Reported value, 2024-12-31: $6.6B Reported value, 2025-03-31: $6.5B Reported value, 2025-06-30: $7B Reported value, 2025-09-30: $8.1B Reported value, 2025-12-31: $10B Reported value, 2026-03-31: $10B Reported value, 2026-06-30: $11.7B 2014-12-31 2017-06-30 2019-12-31 2022-06-30 2026-06-30 $11.7B
View chart data
Period Reported value
2014-12-31 $270.3M
2015-03-31 $221.5M
2015-06-30 $337.1M
2015-09-30 $318.7M
2015-12-31 $307.2M
2016-03-31 $274.5M
2016-06-30 $291.8M
2016-09-30 $329.6M
2016-12-31 $265.4M
2017-03-31 $379.9M
2017-06-30 $474.4M
2017-09-30 $574.2M
2017-12-31 $599.1M
2018-03-31 $1.1B
2018-06-30 $1.4B
2018-09-30 $1.7B
2018-12-31 $1.1B
2019-03-31 $1.5B
2019-06-30 $1.9B
2019-09-30 $1.7B
2019-12-31 $2.7B
2020-03-31 $2.3B
2020-06-30 $3.6B
2020-09-30 $4.2B
2020-12-31 $6B
2021-03-31 $6.4B
2021-06-30 $6.6B
2021-09-30 $6.6B
2021-12-31 $6.8B
2022-03-31 $4.8B
2022-06-30 $3.9B
2022-09-30 $4.3B
2022-12-31 $4.9T
2023-03-31 $4.8B
2023-06-30 $5.3B
2023-09-30 $4.7B
2023-12-31 $6.4B
2024-03-31 $6.8B
2024-06-30 $6.5B
2024-09-30 $6.9B
2024-12-31 $6.6B
2025-03-31 $6.5B
2025-06-30 $7B
2025-09-30 $8.1B
2025-12-31 $10B
2026-03-31 $10B
2026-06-30 $11.7B

Holdings and moves

CompanyShare of portfolioValueSharesChange in shares
MDGLMadrigal Pharmaceuticals, Inc.9.14%$1.1bn1.99M0.0%
ARGXArgenx SE5.62%$658.2m709.4K0.0%
PTCTPTC Therapeutics, Inc.5.39%$631.9m7.75M0.0%
PTGXProtagonist Therapeutics, Inc5.30%$620.4m5.06M0.0%
CGONCG Oncology, Inc.5.17%$605.0m8.51M+21.9% Added
INSMInsmed Inc4.41%$516.3m4.84M0.0%
TNGXTango Therapeutics, Inc.3.71%$434.5m13.90M+4.5% Added
SYRESpyre Therapeutics, Inc.3.22%$377.5m4.25M+1.9% Added
CELCCelcuity Inc.2.95%$345.8m3.30M+8.7% Added
ERASErasca, Inc.2.81%$328.8m17.95M+11.1% Added
RDNTRadnet, Inc.2.55%$298.9m4.85M+13.1% Added
ORKAOruka Therapeutics, Inc.2.55%$298.7m3.14M+52.5% Added
NTRANatera, Inc.2.32%$271.4m1.00M−20.0% Reduced
RAREUltragenyx Pharmaceutical Inc.2.22%$260.3m7.80M+113.7% Added
IRTCIrhythm Holdings, Inc.2.22%$259.6m2.18M+30.8% Added
CYTKCytokinetics Inc2.08%$243.8m2.86M+5.2% Added
KLRAKailera Therapeutics, Inc.2.03%$237.4m10.78MNew
ESTAEstablishment Labs Holdings Inc.1.95%$227.9m2.66M0.0%
GHGuardant Health, Inc.1.90%$222.2m1.48M0.0%
NBIXNeurocrine Biosciences Inc1.82%$213.7m1.27M+19.4% Added
TARSTarsus Pharmaceuticals, Inc.1.80%$211.3m3.36M+0.3%
STOKStoke Therapeutics, Inc.1.57%$184.0m5.62M0.0%
QUREUniqure N.V.1.55%$181.5m3.94M+52.4% Added
ACADAcadia Pharmaceuticals Inc1.54%$180.8m7.14M0.0%
RGENRepligen Corp1.45%$169.3m1.24M+2.9% Added
URGNUrogen Pharma Ltd.1.43%$167.2m4.54M0.0%
GHRSGH Research PLC1.36%$159.5m5.93M0.0%
IMCRImmunocore Holdings plc1.32%$154.6m4.87M0.0%
CMPSCompass Pathways plc1.29%$151.4m10.70M+0.6% Added
IMTXImmatics N.V.1.12%$131.1m12.95M+0.6% Added
ZLABZai Lab Ltd1.07%$124.9m6.57M0.0%
IMVTImmunovant, Inc.1.04%$122.4m3.18M0.0%
BLTEBelite BIO, Inc0.94%$110.2m715.3K0.0%
XNCRXencor Inc0.93%$109.1m6.78M0.0%
TSHATaysha Gene Therapies, Inc.0.79%$92.3m13.56M−0.9% Reduced
COGTCogent Biosciences, Inc.0.76%$89.4m2.31M−57.7% Reduced
ALKSAlkermes plc.0.75%$87.6m1.67M0.0%
GPCRStructure Therapeutics Inc.0.74%$86.3m1.61MNew
REPLReplimune Group, Inc.0.70%$82.0m7.41M+0.7% Added
CSTLCastle Biosciences Inc0.57%$66.3m2.78M+0.7% Added
CADLCandel Therapeutics, Inc.0.56%$66.1m6.42M0.0%
RCKTRocket Pharmaceuticals, Inc.0.52%$60.5m17.69M0.0%
KODKodiak Sciences Inc.0.49%$58.0m1.49M0.0%
AKTSAktis Oncology, Inc.0.44%$51.3m1.59M0.0%
AXGNAxogen, Inc.0.40%$46.7m1.01MNew
DHRDanaher Corporation0.37%$43.8m230.0KNew
CGEMCullinan Therapeutics, Inc.0.37%$43.1m2.36M+38.6% Added
NGNENeurogene Inc.0.37%$42.8m1.36M0.0%
HNGEHinge Health, Inc.0.35%$41.5m500.0K−74.1% Reduced
OBIOOrchestra Biomed Holdings, Inc.0.35%$41.2m9.56M+15.0% Added
SLDBSolid Biosciences Inc.0.33%$38.9m3.89MNew
SVRASavara Inc0.31%$36.7m5.95M0.0%
AQSTAquestive Therapeutics, Inc.0.26%$30.9m7.43M0.0%
KYMRKymera Therapeutics, Inc.0.23%$27.5m240.0K0.0%
VSTMVerastem, Inc.0.22%$25.3m6.64M+0.9% Added
DNTHDianthus Therapeutics, Inc.0.21%$24.2m248.1K0.0%
BBNXBeta Bionics, Inc.0.20%$23.5m1.50M−25.0% Reduced
IPSCCentury Therapeutics, Inc.0.18%$21.3m8.70M0.0%
EVMNEvommune, Inc.0.17%$20.0m1.50M0.0%
BEAMBeam Therapeutics Inc.0.17%$19.6m570.4K0.0%
DFTXDefinium Therapeutics, Inc.0.16%$18.8m400.0K+33.3% Added
IDYAIdeaya Biosciences, Inc.0.12%$13.8m370.4KNew
MISTMilestone Pharmaceuticals Inc.0.09%$10.5m7.83M+23.7% Added
OCGNOcugen, Inc.0.09%$10.2m6.67M0.0%
TENXTenax Therapeutics, Inc.0.09%$10.1m696.6K+88.1% Added
HTFLHeartflow, Inc.0.07%$8.7m295.0K−40.4% Reduced
LRMRLarimar Therapeutics, Inc.0.07%$7.8m2.57M+71.1% Added
LMRILumexa Imaging Holdings, Inc.0.06%$7.3m650.0K0.0%
ALLOAllogene Therapeutics, Inc.0.06%$6.8m3.25MNew
CBIOCrescent Biopharma, Inc.0.06%$6.7m372.9K0.0%
FDMT4d Molecular Therapeutics, Inc.0.05%$6.3m475.7K0.0%
MAZEMaze Therapeutics, Inc.0.05%$6.3m212.0KNew
CAPRCapricor Therapeutics, Inc.0.05%$6.0m250.0K0.0%
KLRSKalaris Therapeutics, Inc.0.04%$5.3m1.30M0.0%
ABVXAbivax S.a.0.03%$3.5m26.4KNew
AVTXAvalo Therapeutics, Inc.0.03%$3.2m175.0K−79.6% Reduced
MDLNMedline Inc.0.02%$2.8m70.0K0.0%
IRONDisc Medicine, Inc.0.02%$2.2m30.0K0.0%
IMAImagenebio, Inc.0.02%$2.0m334.4K0.0%
XGNExagen Inc.0.01%$906,750195.0K−50.7% Reduced
CompanyBought (value)Shares
KLRAKailera Therapeutics, Inc.$237.4m10.78M
RAREUltragenyx Pharmaceutical Inc.$138.5m4.15M
CGONCG Oncology, Inc.$108.7m1.53M
ORKAOruka Therapeutics, Inc.$102.9m1.08M
GPCRStructure Therapeutics Inc.$86.3m1.61M
QUREUniqure N.V.$62.4m1.36M
IRTCIrhythm Holdings, Inc.$61.2m514.1K
AXGNAxogen, Inc.$46.7m1.01M
DHRDanaher Corporation$43.8m230.0K
SLDBSolid Biosciences Inc.$38.9m3.89M
NBIXNeurocrine Biosciences Inc$34.7m205.9K
RDNTRadnet, Inc.$34.7m562.0K
ERASErasca, Inc.$32.8m1.79M
CELCCelcuity Inc.$27.8m265.3K
TNGXTango Therapeutics, Inc.$18.8m600.0K

Change in shares on the previous quarter's 13F, valued at this quarter's reported price.

CompanySold (value)Shares
COGTCogent Biosciences, Inc.−$121.9m−3.15M
HNGEHinge Health, Inc.−$118.7m−1.43M
ISRGIntuitive Surgical−$101.4m−220.0K
NTRANatera, Inc.−$67.9m−250.0K
WAYWaystar Holding Corp.−$39.3m−1.63M
ARWRArrowhead Pharmaceuticals, Inc.−$36.7m−585.7K
SYKStryker Corporation−$32.9m−100.0K
CMPXCompass Therapeutics, Inc.−$22.1m−4.19M
FLGTFulgent Genetics, Inc.−$20.5m−1.29M
AVTXAvalo Therapeutics, Inc.−$12.6m−682.0K
JBIOJade Biosciences, Inc.−$8.1m−573.2K
BBNXBeta Bionics, Inc.−$7.8m−500.0K
IVAInventiva S.a.−$7.2m−1.30M
HTFLHeartflow, Inc.−$5.9m−200.0K
OMDAOmada Health, Inc.−$2.5m−200.0K

Change in shares on the previous quarter's 13F, valued at this quarter's reported price.

CompanyValue last quarterShares
ISRGIntuitive Surgical$101.4m220.0K
WAYWaystar Holding Corp.$39.3m1.63M
ARWRArrowhead Pharmaceuticals, Inc.$36.7m585.7K
SYKStryker Corporation$32.9m100.0K
CMPXCompass Therapeutics, Inc.$22.1m4.19M
FLGTFulgent Genetics, Inc.$20.5m1.29M
JBIOJade Biosciences, Inc.$8.1m573.2K
IVAInventiva S.a.$7.2m1.30M
OMDAOmada Health, Inc.$2.5m200.0K
  • Health Care100.0%

Share of the value held in companies we cover, by sector.

PeriodCopy, a yearS&P 500SharpeS&P 500Biggest dropBeta
Whole backtestFebruary 20, 2015 to November 2, 2026+6.9%+13.4%0.310.71−63.8%1.16
2018 onwardsJanuary 5, 2018 to November 2, 2026+7.2%+13.9%0.290.66−60.3%1.07
Last three yearsNovember 3, 2023 to November 2, 2026+17.6%+21.8%0.581.16−26.4%0.89
Last yearNovember 7, 2025 to November 2, 2026+7.0%+14.2%0.230.84−19.9%0.77

From SEC Form 13F data sets. A 13F lists long positions in US-listed shares at the quarter's end, filed up to 45 days later; it does not show shorts, cash, bonds, non-US holdings or trades within the quarter. Positions in companies outside our coverage are not listed here. Research, not investment advice.