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Orbimed Advisors LLC

13F for June 30, 2026, filed August 14, 2026 · SEC CIK 1055951 · Holdings history from September 30, 2000

Reported value
$5.4bn
92% in companies we cover
Positions we cover
112
Largest EWTX 11.7%
Copy, a year
+9.9%
S&P 500 +11.7%
Copy Sharpe ratio
0.47
S&P 500 0.62

Copy-performance statistics: February 15, 2008 to November 2, 2026. Holdings history can start earlier than the price data used for performance.

Historical holdings

Holdings across the available history, including securities outside our stock coverage. Select a date to view the holdings for that period.

129 reported entries for June 30, 2026.

IssuerClass / typeReported valueQuantity
FORTE BIOSCIENCES INC34962G208 COM NEW $33.5m 1,577,705
GUARDANT HEALTH INC40131M109 · GH COM $87.6m 583,700
HUMANA INC444859102 · HUM COM $65.2m 164,100
IMAGENEBIO INC45175G207 · IMA COM $5.4m 909,269
INSPIREMD INC45779A846 · NSPR COM $2.2m 3,133,405
INTUITIVE SURGICAL INC46120E602 · ISRG COM NEW $62.8m 157,900
JANUX THERAPEUTICS INC47103J105 · JANX COM $8.1m 524,700
KEROS THERAPEUTICS INC492327101 · KROS COM $8.1m 759,155
KINIKSA PHARMACEUTICALS INTLG52694109 · KNSA ORD SHS CL A $26.9m 420,600
KRYSTAL BIOTECH INC501147102 · KRYS COM $30.9m 83,200
LEXEO THERAPEUTICS INC52886X107 · LXEO COM $18.4m 3,947,850
LIFESTANCE HEALTH GROUP INC53228F101 · LFST COM $10.1m 947,400
MBX BIOSCIENCES INC55287L101 · MBX COM $189.3m 3,428,736
MERCK & CO INC58933Y105 · MRK COM $85.2m 663,400
MINERALYS THERAPEUTICS INC603170101 · MLYS COM $56.9m 2,110,300
MONOPAR THERAPEUTICS INC61023L207 · MNPR COM NEW $14.6m 157,423
NATERA INC632307104 · NTRA COM $71.1m 262,000
NEKTAR THERAPEUTICS640268306 · NKTR COM NEW $32.5m 465,346
NEUMORA THERAPEUTICS INC.640979100 · NMRA COM $3.6m 2,139,882
NEUROPACE INC641288105 · NPCE COM $23.9m 1,505,125
OCULAR THERAPEUTIX INC67576A100 · OCUL COM $2.2m 220,000
ODYSSEY THERAPEUTICS INC67613T104 · ODTX COMMON STOCK $56.2m 3,001,198
ORIC PHARMACEUTICALS INC68622P109 · ORIC COM $21.8m 2,015,000
OVID THERAPEUTICS INC690469101 · OVID COM $2.0m 747,000
PALISADE BIO INC696389402 · PALI COM $4.9m 2,333,000
PALVELLA THERAPEUTICS INC NE697947109 · PVLA COMCall $6.1m 40,000
PALVELLA THERAPEUTICS INC NE697947109 · PVLA COM $44.7m 292,360
PHARVARIS N VN69605108 · PHVS COM $7.1m 205,400
PRAXIS PRECISION MEDICINES I74006W207 · PRAX COM NEW $77.0m 230,100

Values use the units disclosed in the source. Where a dollar scale cannot be established, the original amount is shown as filed. Rows may include separate allocations, options and principal amounts; these are kept separate from the covered-stock portfolio used for performance.

How copying its 13F would have done

$5.0k$10.0k$20.0k$40.0k$80.0k 2008201020122014201620182020202220242026 $78.8k$58.7k
CopyS&P 500 $10,000 copying Orbimed Advisors LLC's usable filed holdings in companies we cover from February 15, 2008, rebalancing at the first weekly close after each usable filing and holding until the next, against the S&P 500 (total return). Missing prices carry their last observed value. Marked weekly, log scale. Before costs and taxes; misses trading within each quarter and anything 13F does not show (shorts, cash, bonds, non-US holdings).

Biggest drop −52.3% (S&P 500 −50.8%); beta 0.87; alpha +0.7% a year (t = 0.20); last 12 months +4.8% against +12.1%.

Reported value by quarter

Orbimed Advisors LLC: 13F reported value Total reported value where the source's dollar units can be established. Earlier filings in thousands of dollars are converted; dates with unresolved value units are omitted.
$0 $5B $10B $15B Reported value, 2008-03-31: $3.1B Reported value, 2008-06-30: $3.4B Reported value, 2008-09-30: $3.5B Reported value, 2008-12-31: $2.7B Reported value, 2009-03-31: $2.4B Reported value, 2009-06-30: $2.6B Reported value, 2009-09-30: $2.8B Reported value, 2009-12-31: $2.6B Reported value, 2010-03-31: $3.4B Reported value, 2010-06-30: $2.7B Reported value, 2010-09-30: $2.9B Reported value, 2010-12-31: $2.8B Reported value, 2011-03-31: $3B Reported value, 2011-06-30: $3.2B Reported value, 2011-09-30: $2.7B Reported value, 2011-12-31: $3B Reported value, 2012-03-31: $3.4B Reported value, 2012-06-30: $3.6B Reported value, 2012-09-30: $3.5B Reported value, 2012-12-31: $3.3B Reported value, 2013-03-31: $4.3B Reported value, 2013-06-30: $4.7B Reported value, 2013-09-30: $5.6B Reported value, 2013-12-31: $6.8B Reported value, 2014-03-31: $8.1B Reported value, 2014-06-30: $8.5B Reported value, 2014-09-30: $9.6B Reported value, 2014-12-31: $10.5B Reported value, 2015-03-31: $11.7B Reported value, 2015-06-30: $13.6B Reported value, 2015-09-30: $9.9B Reported value, 2015-12-31: $11B Reported value, 2016-03-31: $9.5B Reported value, 2016-06-30: $9.6B Reported value, 2016-09-30: $8.8B Reported value, 2016-12-31: $7.8B Reported value, 2017-03-31: $8.8B Reported value, 2017-06-30: $9.5B Reported value, 2017-09-30: $10.5B Reported value, 2017-12-31: $7.9B Reported value, 2018-03-31: $8.1B Reported value, 2018-06-30: $8.4B Reported value, 2018-09-30: $8.3B Reported value, 2018-12-31: $5.4B Reported value, 2019-03-31: $6.5B Reported value, 2019-06-30: $6.5B Reported value, 2019-09-30: $5.3B Reported value, 2019-12-31: $7B Reported value, 2020-03-31: $6B Reported value, 2020-06-30: $7.1B Reported value, 2020-09-30: $8B Reported value, 2020-12-31: $11.4B Reported value, 2021-03-31: $10.7B Reported value, 2021-06-30: $9.9B Reported value, 2021-09-30: $9.1B Reported value, 2021-12-31: $7.8B Reported value, 2022-03-31: $6.2B Reported value, 2022-06-30: $5.5B Reported value, 2022-09-30: $5.4B Reported value, 2022-12-31: $5.2B Reported value, 2023-03-31: $5.1B Reported value, 2023-06-30: $5.5B Reported value, 2023-09-30: $4.7B Reported value, 2023-12-31: $5B Reported value, 2024-03-31: $5.5B Reported value, 2024-06-30: $5.1B Reported value, 2024-09-30: $5.5B Reported value, 2024-12-31: $4.9B Reported value, 2025-03-31: $4.2B Reported value, 2025-06-30: $4B Reported value, 2025-09-30: $4.3B Reported value, 2025-12-31: $4.9B Reported value, 2026-03-31: $5B Reported value, 2026-06-30: $5.4B 2008-03-31 2011-12-31 2015-09-30 2019-06-30 2023-03-31 2026-06-30 $5.4B
View chart data
Period Reported value
2008-03-31 $3.1B
2008-06-30 $3.4B
2008-09-30 $3.5B
2008-12-31 $2.7B
2009-03-31 $2.4B
2009-06-30 $2.6B
2009-09-30 $2.8B
2009-12-31 $2.6B
2010-03-31 $3.4B
2010-06-30 $2.7B
2010-09-30 $2.9B
2010-12-31 $2.8B
2011-03-31 $3B
2011-06-30 $3.2B
2011-09-30 $2.7B
2011-12-31 $3B
2012-03-31 $3.4B
2012-06-30 $3.6B
2012-09-30 $3.5B
2012-12-31 $3.3B
2013-03-31 $4.3B
2013-06-30 $4.7B
2013-09-30 $5.6B
2013-12-31 $6.8B
2014-03-31 $8.1B
2014-06-30 $8.5B
2014-09-30 $9.6B
2014-12-31 $10.5B
2015-03-31 $11.7B
2015-06-30 $13.6B
2015-09-30 $9.9B
2015-12-31 $11B
2016-03-31 $9.5B
2016-06-30 $9.6B
2016-09-30 $8.8B
2016-12-31 $7.8B
2017-03-31 $8.8B
2017-06-30 $9.5B
2017-09-30 $10.5B
2017-12-31 $7.9B
2018-03-31 $8.1B
2018-06-30 $8.4B
2018-09-30 $8.3B
2018-12-31 $5.4B
2019-03-31 $6.5B
2019-06-30 $6.5B
2019-09-30 $5.3B
2019-12-31 $7B
2020-03-31 $6B
2020-06-30 $7.1B
2020-09-30 $8B
2020-12-31 $11.4B
2021-03-31 $10.7B
2021-06-30 $9.9B
2021-09-30 $9.1B
2021-12-31 $7.8B
2022-03-31 $6.2B
2022-06-30 $5.5B
2022-09-30 $5.4B
2022-12-31 $5.2B
2023-03-31 $5.1B
2023-06-30 $5.5B
2023-09-30 $4.7B
2023-12-31 $5B
2024-03-31 $5.5B
2024-06-30 $5.1B
2024-09-30 $5.5B
2024-12-31 $4.9B
2025-03-31 $4.2B
2025-06-30 $4B
2025-09-30 $4.3B
2025-12-31 $4.9B
2026-03-31 $5B
2026-06-30 $5.4B

Latest covered holdings and moves

Covered holdings as of June 30, 2026.

CompanyShare of portfolioValueSharesChange in shares
EWTXEdgewise Therapeutics, Inc.11.68%$630.5m15.52M0.0%
ELVNEnliven Therapeutics, Inc.6.37%$343.9m6.78M−14.9% Reduced
LLYLilly (Eli)5.73%$309.3m257.9K+8.9% Added
MBXMBX Biosciences, Inc.3.51%$189.3m3.43M−5.7% Reduced
AZNAstrazeneca PLC3.17%$171.1m915.7K+36.6% Added
GPCRStructure Therapeutics Inc.2.20%$118.6m2.21M+49.7% Added
SIONSionna Therapeutics, Inc.2.08%$112.4m2.56M−27.6% Reduced
CRVSCorvus Pharmaceuticals, Inc.1.98%$107.0m7.17M0.0%
AVBPArrivent Biopharma, Inc.1.95%$105.2m3.03M0.0%
GHGuardant Health, Inc.1.62%$87.6m583.7K+34.1% Added
ARGXArgenx SE1.60%$86.2m92.9K−32.2% Reduced
MRKMerck & Co.1.58%$85.2m663.4K0.0%
QUREUniqure N.V.1.54%$83.3m1.81M−15.4% Reduced
PRAXPraxis Precision Medicines, Inc.1.43%$77.0m230.1K+33.4% Added
EWEdwards Lifesciences1.40%$75.5m834.9K−32.2% Reduced
PRLDPrelude Therapeutics Inc1.35%$73.2m13.72M+25.8% Added
ABVXAbivax S.a.1.35%$72.8m546.5K+17.4% Added
DYNDyne Therapeutics, Inc.1.33%$71.9m3.24M+10.9% Added
NTRANatera, Inc.1.32%$71.1m262.0K0.0%
CGONCG Oncology, Inc.1.28%$69.1m972.8K+2.6% Added
UNHUnitedHealth Group1.24%$67.0m161.1KNew
SPRYARS Pharmaceuticals, Inc.1.23%$66.4m8.29M0.0%
ASNDAscendis Pharma A/s1.21%$65.2m244.5K+34.3% Added
HUMHumana1.21%$65.2m164.1KNew
COGTCogent Biosciences, Inc.1.21%$65.1m1.68M+422.0% Added
BSXBoston Scientific1.17%$63.3m1.48M−37.7% Reduced
ISRGIntuitive Surgical1.16%$62.8m157.9K−24.3% Reduced
MLYSMineralys Therapeutics, Inc.1.05%$56.9m2.11M+2.8% Added
ODTXOdyssey Therapeutics, Inc.1.04%$56.2m3.00MNew
XENEXenon Pharmaceuticals Inc.1.00%$53.9m892.5K−15.8% Reduced
ARQTArcutis Biotherapeutics, Inc.0.99%$53.5m2.04MNew
BMYBristol Myers Squibb0.99%$53.3m925.0K0.0%
QTTBQ32 Bio Inc.0.97%$52.6m4.13M+83.2% Added
SYKStryker Corporation0.93%$50.1m159.1K−12.8% Reduced
CAICaris Life Sciences, Inc.0.93%$50.0m2.81M0.0%
TMOThermo Fisher Scientific0.84%$45.5m90.7K+95.1% Added
PVLAPalvella Therapeutics, Inc.0.83%$44.7m292.4K+117.2% Added
ELVElevance Health0.82%$44.4m114.7K0.0%
STTKShattuck Labs, Inc.0.81%$43.8m6.31M0.0%
UPBUpstream Bio, Inc.0.73%$39.4m5.69M0.0%
RYTMRhythm Pharmaceuticals, Inc.0.66%$35.9m322.9K+2.8% Added
SNDXSyndax Pharmaceuticals Inc0.63%$33.7m1.54M+60.2% Added
CMPXCompass Therapeutics, Inc.0.62%$33.3m15.22M0.0%
NKTRNektar Therapeutics0.60%$32.5m465.3K+69.2% Added
KRYSKrystal Biotech, Inc.0.57%$30.9m83.2K+20.4% Added
AXSMAxsome Therapeutics, Inc.0.53%$28.8m117.6K−45.0% Reduced
KNSAKiniksa Pharmaceuticals International, plc0.50%$26.9m420.6K+132.9% Added
TRVITrevi Therapeutics, Inc.0.49%$26.7m1.43M−41.7% Reduced
IRONDisc Medicine, Inc.0.48%$26.2m357.5K−66.5% Reduced
WSTWest Pharmaceutical Services0.47%$25.3m70.6KNew
RLMDRelmada Therapeutics, Inc.0.47%$25.1m3.63M−23.0% Reduced
URGNUrogen Pharma Ltd.0.46%$24.9m676.2K−22.8% Reduced
STROSutro Biopharma, Inc.0.46%$24.7m743.9K−7.1% Reduced
SVRASavara Inc0.45%$24.4m3.96M+523.6% Added
NPCENeuropace Inc0.44%$23.9m1.51M−28.2% Reduced
AURAAura Biosciences, Inc.0.44%$23.7m3.33MNew
ORICOric Pharmaceuticals, Inc.0.40%$21.8m2.02M−25.2% Reduced
HELPHelus Pharma Inc.0.40%$21.6m3.27M−14.6% Reduced
BCRXBiocryst Pharmaceuticals Inc0.34%$18.5m1.85M+29.9% Added
BIOABioage Labs, Inc.0.34%$18.4m752.2K+5.7% Added
LXEOLexeo Therapeutics, Inc.0.34%$18.4m3.95M+9.6% Added
WHWKWhitehawk Therapeutics, Inc.0.33%$18.0m3.93M−5.6% Reduced
DFTXDefinium Therapeutics, Inc.0.32%$17.2m365.4K−54.6% Reduced
SYRESpyre Therapeutics, Inc.0.31%$16.5m186.1KNew
CRBPCorbus Pharmaceuticals Holdings, Inc.0.30%$16.3m1.74M0.0%
VERAVera Therapeutics, Inc.0.29%$15.9m369.6K0.0%
ALMSAlumis Inc.0.29%$15.4m548.2K0.0%
EYPTEyepoint, Inc.0.28%$15.3m1.07M0.0%
WATWaters Corporation0.28%$15.1m40.3KNew
MNPRMonopar Therapeutics0.27%$14.6m157.4KNew
TVTXTravere Therapeutics, Inc.0.27%$14.4m253.0KNew
TSHATaysha Gene Therapies, Inc.0.25%$13.6m2.00MNew
BIIBBiogen0.25%$13.3m61.6K0.0%
RVMDRevolution Medicines, Inc.0.24%$13.2m70.5K+35.6% Added
DNTHDianthus Therapeutics, Inc.0.21%$11.2m115.0KNew
SPRBSpruce Biosciences, Inc.0.20%$10.8m200.0KNew
LFSTLifestance Health Group, Inc.0.19%$10.1m947.4K+89.5% Added
ERASErasca, Inc.0.17%$9.1m495.9KNew
TARAProtara Therapeutics, Inc.0.16%$8.5m2.22MNew
KROSKeros Therapeutics, Inc.0.15%$8.1m759.2K0.0%
JANXJanux Therapeutics, Inc.0.15%$8.1m524.7K−46.7% Reduced
TECXTectonic Therapeutic, Inc.0.14%$7.8m226.6K0.0%
ACETAdicet Bio, Inc.0.14%$7.3m844.8K−17.8% Reduced
PHVSPharvaris N.V.0.13%$7.1m205.4K0.0%
ANROAlto Neuroscience, Inc.0.13%$6.8m257.9K+53.9% Added
ZNTLZentalis Pharmaceuticals, Inc.0.13%$6.7m1.39MNew
DRUGBright Minds Biosciences Inc.0.12%$6.5m93.0K+132.5% Added
ALXOALX Oncology Holdings Inc0.11%$5.9m2.87M0.0%
XLOXilio Therapeutics, Inc.0.10%$5.7m592.3KNew
BCAXBicara Therapeutics Inc.0.10%$5.7m191.1K−71.4% Reduced
IMAImagenebio, Inc.0.10%$5.4m909.3K+140.2% Added
PTGXProtagonist Therapeutics, Inc0.10%$5.2m42.1K0.0%
ALNYAlnylam Pharmaceuticals, Inc.0.10%$5.1m17.0K−85.7% Reduced
PALIPalisade BIO, Inc.0.09%$4.9m2.33M0.0%
PTCTPTC Therapeutics, Inc.0.07%$4.0m49.1K0.0%
AORTArtivion, Inc.0.07%$3.9m175.0K+15.9% Added
NMRANeumora Therapeutics, Inc.0.07%$3.6m2.14MNew
ACADAcadia Pharmaceuticals Inc0.06%$3.5m137.0KNew
AMLXAmylyx Pharmaceuticals, Inc.0.06%$3.3m183.4KNew
TYRATyra Biosciences, Inc.0.06%$3.3m102.0KNew
RAPPRapport Therapeutics, Inc.0.06%$3.2m76.6KNew
AGMBAgomab Therapeutics NV0.05%$2.5m192.7KNew
TARSTarsus Pharmaceuticals, Inc.0.04%$2.2m35.6KNew
ACRSAclaris Therapeutics, Inc.0.04%$2.2m421.5KNew
CYTKCytokinetics Inc0.04%$2.2m25.8KNew
NSPRInspiremd, Inc.0.04%$2.2m3.13M0.0%
OCULOcular Therapeutix, Inc0.04%$2.2m220.0KNew
EVMNEvommune, Inc.0.04%$2.1m161.0KNew
BLTEBelite BIO, Inc0.04%$2.0m13.3KNew
OVIDOvid Therapeutics Inc.0.04%$2.0m747.0KNew
EPRXEupraxia Pharmaceuticals Inc.0.03%$1.8m269.0KNew
TRAWTraws Pharma, Inc.0.02%$1.0m1.20M+98.7% Added
CompanyBought (value)Shares
UNHUnitedHealth Group$67.0m161.1K
HUMHumana$65.2m164.1K
ODTXOdyssey Therapeutics, Inc.$56.2m3.00M
ARQTArcutis Biotherapeutics, Inc.$53.5m2.04M
COGTCogent Biosciences, Inc.$52.6m1.36M
AZNAstrazeneca PLC$45.9m245.5K
GPCRStructure Therapeutics Inc.$39.4m734.0K
WSTWest Pharmaceutical Services$25.3m70.6K
LLYLilly (Eli)$25.3m21.1K
PVLAPalvella Therapeutics, Inc.$24.1m157.8K
QTTBQ32 Bio Inc.$23.9m1.88M
AURAAura Biosciences, Inc.$23.7m3.33M
GHGuardant Health, Inc.$22.3m148.5K
TMOThermo Fisher Scientific$22.2m44.2K
SVRASavara Inc$20.5m3.32M

Change in shares on the previous quarter's 13F, valued at this quarter's reported price.

CompanySold (value)Shares
ELVNEnliven Therapeutics, Inc.−$60.0m−1.18M
PFEPfizer−$54.7m−1.95M
IRONDisc Medicine, Inc.−$51.9m−710.0K
DHRDanaher Corporation−$50.4m−265.8K
SIONSionna Therapeutics, Inc.−$42.9m−974.8K
ARGXArgenx SE−$40.8m−44.0K
BSXBoston Scientific−$38.4m−898.9K
EWEdwards Lifesciences−$35.8m−395.7K
ALNYAlnylam Pharmaceuticals, Inc.−$30.7m−102.0K
AXSMAxsome Therapeutics, Inc.−$23.6m−96.3K
BTSGBrightspring Health Services, Inc.−$21.2m−497.8K
DFTXDefinium Therapeutics, Inc.−$20.6m−438.6K
ISRGIntuitive Surgical−$20.2m−50.8K
TRVITrevi Therapeutics, Inc.−$19.1m−1.02M
QUREUniqure N.V.−$15.1m−328.7K

Change in shares on the previous quarter's 13F, valued at this quarter's reported price.

CompanyValue last quarterShares
PFEPfizer$54.7m1.95M
DHRDanaher Corporation$50.4m265.8K
BTSGBrightspring Health Services, Inc.$21.2m497.8K
AMGNAmgen$14.0m39.9K
ALHCAlignment Healthcare, Inc.$13.9m791.0K
REGNRegeneron Pharmaceuticals$11.4m14.7K
CARLCarlsmed, Inc.$11.3m1.25M
GILDGilead Sciences$8.3m59.6K
HRTXHeron Therapeutics, Inc.$7.9m9.82M
AVTXAvalo Therapeutics, Inc.$7.1m475.2K
CMPSCompass Pathways plc$6.4m1.15M
ADCTADC Therapeutics SA$4.9m1.32M
CGEMCullinan Therapeutics, Inc.$3.5m243.0K
JBIOJade Biosciences, Inc.$2.6m185.0K
CCCCC4 Therapeutics, Inc.$2.3m856.4K
RCELAvita Medical, Inc.$2.0m544.9K
VTGNVistagen Therapeutics, Inc.$1.7m3.06M
  • Health Care100.0%

Share of the value held in companies we cover, by sector.

PeriodCopy, a yearS&P 500SharpeS&P 500Biggest dropBeta
Whole backtestFebruary 15, 2008 to November 2, 2026+9.9%+11.7%0.470.62−52.3%0.87
2010 to 2017January 8, 2010 to December 29, 2017+18.2%+13.5%1.080.98−25.4%0.89
2018 onwardsJanuary 5, 2018 to November 2, 2026+3.8%+13.9%0.160.66−52.3%0.96
Last three yearsNovember 3, 2023 to November 2, 2026+16.0%+21.8%0.541.16−34.1%1.02
Last yearNovember 7, 2025 to November 2, 2026+7.4%+14.2%0.250.84−22.4%0.92

From SEC Form 13F data sets. A 13F lists long positions in US-listed shares at the quarter's end, filed up to 45 days later; it does not show shorts, cash, bonds, non-US holdings or trades within the quarter. Positions in companies outside our coverage are not listed here. Research, not investment advice.